CAS: 1426129-50-1; (R)-Tert-Butyl (1-([1,1'-Biphenyl]-4-yl)-3-Hydroxypropan-2-yl)Carbamate

相似化合物

153037-40-2 1573000-33-5 147923-08-8

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate 22H23N°C22H23NO (S)-1-([1,1'-biphenyl]-4-yl)-3-tert-butoxypropan-2-ol (1-([1,1'-biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid ethyl ester amino>-4-propanal(R)-α-(1,1-dimethylethoxy)carbonylamino1,1'-biphenyl-4-propanal yl)-4-amino>-2-methyl-2-pentenoateethyl 5-(4-1,1'-biphenylyl)-4-(1,1-dimethylethoxy)carbonylamino-2-methyl-2-pentenoate (2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

4-联苯乙酸置于n-甲基吗啉,盐酸,Transaminase,磷酸吡哆醛,水,Sodium Formate,异丙胺,三乙胺体系中,用 Aq. Phosphate Buffer,乙醇,二氯甲烷,甲基叔丁基醚,二乙二醇二甲醚,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 27.5H,反应生成N-[(1R)-2-[1,1'-联苯]-4-基-1-(羟基甲基)乙基]氨基甲酸叔丁酯
参考文献:一种用于制备沙库比曲中间体的制备方法
标题:一种用于制备沙库比曲中间体的制备方法
摘要:本发明公开一种中间体化合物(R)‑叔丁基(1‑((1,1'‑联苯)‑4‑基)‑3‑羟基丙烷‑2‑基)氨基甲酸酯的制备方法,其制备方法如式所示.本发明的制备方法步骤简短,提高了反应收率,反应条件温和,反应过程中得到的中间体大部分不需纯化,可直接进行下一步反应,有利于大批量的合成,利用氨基转移酶高效地合成立体专一性的手性胺,更适合于工业化生产.

专利信息

专利号:US-2016200665-A1
优先权日:2013-08-21
标 题:Synthesis of biphenylalaninol via novel intermediates
发明人：ZIMMERMANN AXEL; HERMSEN PETRUS JOHANNES; HANBAUER MARTIN HELMUT FRIEDRICH
权利人:DPX HOLDINGS BV
摘要:The invention relates to a novel synthesis route towards R-biphenylalaninol and to the intermediates applied in this synthesis route. The process according to the invention and the intermediate compounds are useful in the synthesis of pharmaceutically active compounds.

专利号:US-9139515-B2
优先权日:2011-08-19
标 题:Synthesis of R-biphenylalaninol
发明人：HERMSEN PETRUS JOHANNES; ERMANN PETER HANS; RIEBEL PETER HANS; WOLBERG MICHAEL; DE VRIES ANDREAS HENDRIKUS MARIA
权利人:HERMSEN PETRUS JOHANNES; ERMANN PETER HANS; RIEBEL PETER HANS; WOLBERG MICHAEL; DE VRIES ANDREAS HENDRIKUS MARIA; DPX HOLDINGS BV
摘要:This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The invention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.

专利号:US-2014296559-A1
优先权日:2011-08-19
标题 :Synthesis of r-biphenylalaninol

专利号:WO-2015024991-A1
优先权日:2013-08-21
标 题 :Synthesis of biphenylalaninol via novel intermediates

专利号:CN-119528749-A
优先权日:2024-12-05
标题 :Synthesis method of (r) -tert-butyl (1- ([ 1,1' -biphenyl ] -4-yl) -3-hydroxy propane-2-yl) carbamate