CAS: 13669-10-8; Ethyl 3-Oxo-3-(Thiophen-2-yl)Propanoate

相似化合物

188937-11-3 86366-54-3 224319-23-7

上下游产品

3-Oxo-3-(Thiophen-2-yl)Propanoic Acid 69931-93-7

2-乙酰基噻吩置于potassium Tert-Butylate体系中,用 甲苯 用作溶剂,化学反应 1.25H,以90%的收率获得2-噻吩甲酰乙酸乙酯
参考文献: Pyridazin-3(2H)-One Derivatives And Their Use As Pde4 Inhibitors[fr] Nouveaux Derives De Pyridazin-3(2H)-One Et Leurs Utilisation En Tant Qu'Inhibiteurs De Pde4
标题: Pyridazin-3(2H)-One Derivatives And Their Use As Pde4 Inhibitors[fr] Nouveaux Derives De Pyridazin-3(2H)-One Et Leurs Utilisation En Tant Qu'Inhibiteurs De Pde4
摘要:该发明涉及新的治疗上有用的吡啶并嗪-3(2H)-酮衍生物,以及它们的制备方法和含有它们的药物组合物.这些化合物是磷酸二酯酶4(pde4)的有效和选择性抑制剂,因此在治疗,预防和抑制相关病理条件,疾病和障碍方面具有用途,特别是哮喘,慢性阻塞性肺病,类风湿性关节炎,局部性皮炎,牛皮癣或肠易激综合征.

专利信息

专利号:US-7659409-B2
优先权日:2002-03-19
标 题 :3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
发明人：TAKEHARA JUN; QU JINGPING; KANNO KAZUAKI; KAWABATA HIROSHI; DEKISHIMA YASUMASA; UEDA MAKOTO; ENDO KYOKO; MURAKAMI TAKESHI; SASAKI TOMOKO; UEHARA HISATOSHI; MATSUMOTO YOUICHI; SUZUKI SHIHOMI
权利人:MITSUBISHI CHEM CORP
摘要:The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. n According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a β-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. n n(each of the substituents is as described in claim 1 ).

专利号:CN-116554029-B
优先权日:2023-05-12
标题:Synthesis method of aromatic formyl ethyl acetate

专利号:CN-119330931-A
优先权日:2024-10-17
标 题:Synthesis method of 2- (benzenesulfonamide) -3-oxo-3-heterocyclic propionate compound