CAS: 128495-46-5; 4-Fluoro-3-Methoxybenzaldehyde

该化合物是一种芳香的藻类,其特点是在苯环上存在氟原子和甲氧基组;该化合物的特点是苯甲醚功能组,因其在各种有机合成反应中具有回活动性而闻名;氟代基物质通常会增强化合物的电益特性,使其在核循环替代反应中有用;甲基氧化合物组有助于该化合物的总体极性,并能影响其在有机溶剂中的溶解性;就物理特性而言,4-氟-3-甲氧基苯甲酰胺基物质一般无色,可与黄色液体或固体无色,这取决于温度和纯度;氟代物质在合成药物,农业化学品和其他有机化合物时,由于其独特的电子特性和再活性作用,具有应用.在处理该化合物时,应当采取安全防范措施,因为许多有机化学品具有潜在的毒性和环境影响.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号128495-45-4 4-氟-3-甲氧基苯甲醇 | CAS号82846-18-2 4-氟-3-甲氧基苯甲酸 | CAS号63762-78-7 2-氟-5-甲基苯甲醚 | CAS号63762-79-8 2-氟-5-甲基苯酚 | CAS号452-84-6 2-氟-5-甲基苯胺 | CAS号55496-52-1 4-氯-7-甲氧基喹唑啉 | CAS号295779-82-7 6-氟-5-甲氧基-2,3-二... | CAS号870837-18-6 3-甲氧基-4-(4-甲基-1... | CAS号870837-19-7 3-methoxy-4-(5-... | CAS号630424-79-2 4-氟-3-甲氧基肉桂酸 | CAS号1036711-00-8 6-Fluoro-7-meth... | CAS号103438-85-3 4-氟-3-羟基苯甲醛 | CAS号117902-15-5 4-氟-3-甲氧基苯酚 | CAS号128495-45-4 4-氟-3-甲氧基苯甲醇 | CAS号141080-73-1 4-氟-3-甲氧基苄溴

合成工艺路线路线简述

    4-氟-3-甲氧基苯甲酸甲酯置于吡啶,Chromium(Vi) Oxide,Lithium Aluminium Tetrahydride体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 1.5H,反应生成3-甲氧基-4-氟苯甲醛
    参考文献:Compound Of Camptothecin And Preparation And Use Thereof
    标题:Compound Of Camptothecin And Preparation And Use Thereof
    摘要:本公开涉及一种式i的化合物,以及其药物组合物和用作抗肿瘤药物的用途.

    海关参考信息

    专利信息


    专利号:US-8927560-B2
    优先权日:2010-12-06
    标 题 :4-Aza-2, 3-didehydropodophyllotoxin compounds and process for the preparation thereof
    发明人:AHMED KAMAL; PAIDAKULA SURESH; BANALA ASHWINI KUMAR; ADLA MALLAREDDY; PAPAGARI VENKAT REDDY; JAKI RASHEED TAMBOLI
    权利人:AHMED KAMAL; PAIDAKULA SURESH; BANALA ASHWINI KUMAR; ADLA MALLAREDDY; PAPAGARI VENKAT REDDY; JAKI RASHEED TAMBOLI; COUNCIL SCIENT IND RES
    摘要:The present invention provides 4-Aza-2,3-didehydropodophyllotoxin compound of general formula A (4a-4z and 4aa-4ae) as useful potential antitumour agents against human cancer cell lines. The present invention further provides a process for the synthesis of 4-Aza-2,3-didehydropodophyllotoxin compounds (4a-4z and 4aa-4ae).

    专利号:US-2012053165-A1
    优先权日:2009-03-03
    标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
    发明人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
    权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9423395-B2
    优先权日:2013-01-14
    标 题:Fluorescent cell cycle probe having M-phase specificity
    发明人:CHANG YOUNG-TAE; ZHAI DUANTING; LEE SUNG-CHAN; YUN SEONG-WOOK; JEONG YUN-MI; KANG NAM-YOUNG; PARK SUNG-JIN
    权利人:NAT UNIV SINGAPORE; AGENCY SCIENCE TECH & RES
    摘要:The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.

    专利号:US-7432284-B2
    优先权日:2002-09-19
    标题 :Estrogen receptor modulators
    发明人:PARKER DANN LEROY; WILKENING ROBERT R; MENG DONGFANG; RATCLIFFE RONALD W
    权利人:MERCK & CO INC
    摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Pagets disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

    专利号:US-12428380-B2
    优先权日:2023-06-28
    标 题 :Compounds
    发明人:BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
    权利人:Psylo Pty Ltd
    摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
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    合成参考文献


    参考文献:10.1007/s00044-015-1375-z
    摘要:Hatti I, Sreenivasulu R, Jadav SS, Jayaprakash V, Kumar CG, Raju RR. Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives. Medicinal Chemistry Research. 2015 May 21;24(8):3305–13. doi: 10.1007/s00044-015-1375-z.
    参考文献:10.1007/s11224-015-0704-7
    摘要:Nieto CI, Cabildo P, Claramunt RM, Cornago P, Sanz D, Torralba MC, Torres MR, Ferraro MB, Alkorta I, Marín-Luna M, Elguero J. The structure of β-diketones related to curcumin determined by X-ray crystallography, NMR (solution and solid state) and theoretical calculations. Structural Chemistry. 2015 Dec 09;27(2):705–30. doi: 10.1007/s11224-015-0704-7.
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