CAS: 114861-22-2; (3As,5S,6R,6As)-5-(Hydroxymethyl)-2,2-Dimethyltetrahydrofuro[2,3-D][1,3]Dioxol-6-Ol

相似化合物

37077-81-9 20031-21-4 6612-91-5

上下游产品

CAS号609-06-3 L-木糖 | CAS号67-64-1 丙酮 | CAS号131156-47-3 (3AS,3BR,7AS,8A... | CAS号87-72-9 L-阿拉伯糖 | CAS号3080-30-6 1-O-乙酰基-2,3,5-O... | CAS号1018898-77-5 (3aS,5R,6R,6aS)... | CAS号59920-31-9 Α-葡萄糖苷酶 | CAS号171866-30-1 1,3,5-三苯甲酰基-α-L-呋喃核糖 | CAS号171721-00-9 L-氟糖

L-木糖置于盐酸,硫酸,Copper(II) Sulfate体系中,化学反应 27.0H,反应生成(3As,5S,6R,6As)-5-(羟基甲基)-2,2-二甲基四氢呋喃并[2,3-D][1,3]二氧代l-6-醇
参考文献:Synthesis And Biological Evaluation Of Some 4'-C-(Hydroxymethyl)-α-And-β-D-Arabinofuranosyl Pyrimidine And Adenine Nucleosides
标题:Synthesis And Biological Evaluation Of Some 4'-C-(Hydroxymethyl)-α-And-β-D-Arabinofuranosyl Pyrimidine And Adenine Nucleosides
摘要:一系列4'-C-(羟甲基)嘧啶和嘌呤核苷类似物已经利用标准方法制备,α和β异构体已被分离.这些类似物是我们持续努力寻找新的抗癌药物以及探索这些类似物与引导核苷三磷酸的代谢途径中的初始激活酶的底物特异性的一部分.尽管对ccrf-Cem细胞(一种t细胞来源的急性淋巴细胞白血病)没有细胞毒性,但许多这些化合物被用作各种人类核苷酸激酶的底物,包括脱氧胞苷激酶,胸苷激酶1和胸苷激酶2.由于4'-C-(羟甲基)阿拉伯核糖胞嘧啶类似物被鉴定为与脱氧胞苷激酶具有非常好的底物特性,因此对其在cem细胞中的代谢进行了评估.这些结果表明,带有这种修饰的核苷类似物可以在人类细胞中被激活而不具有细胞毒性,这表明它们应该被检查其抗病毒活性.
Doi:10.1135/cccc20061063

专利信息

专利号:US-10889574-B2
优先权日:2016-06-17
标 题 :Method for producing diphenylmethane derivative
发明人：YOON HEE-KYOON; PARK SE-HWAN; YOON JI-SUNG; CHOI SOONGYU; SEO HEE JEONG; PARK EUN-JUNG; KONG YOUNGGYU; SONG KWANG-SEOP; KIM MIN JU; PARK SO OK
权利人:DAE WOONG PHARMA; GREEN CROSS CORP
摘要:The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.