CAS: 112-76-5; Octadecanoyl Chloride

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Sodium Stearate置于氯化亚砜体系中,化学反应 2.0H,反应生成十八烷酰氯
参考文献:Studies On Selectin Blocker. 9. Sars Of Non-Sugar Selectin Blocker Against E-,P-,L-Selectin Bindings
标题:Studies On Selectin Blocker. 9. Sars Of Non-Sugar Selectin Blocker Against E-,P-,L-Selectin Bindings
摘要:As A Part Of Study Of Selectin Blockers,We Have Already Reported That A Non-Sugar Selectin Antagonist (3) Was Successfully Discovered Using A Computational Screening (Hiramatsu,Y.; Tsukida,T.; Nakai,Y.; Inoue,Y.; Kondo,H. J. Med. Chem. 2000,43 1476). To Investigate The Sars Of Compound 3 Against E-,P-,And L-Selectins,We Synthesized The Derivatives Of Compound 3 And Evaluated Their Inhibitory Activities Toward Selectin Bindings. The Structural Diversity Of Compound 3 Contained The Following. (1) A Modification Of The Spacer Unit (4-7),(2) A Modification Of The Tail Unit (8-11),(3) A Modification Of The Head Unit (12-18). As A Result,It Was Found That A Non-Sugar Based Selectin Blocker (3) Could Be A Potential Lead Compound For E-,P-,And L-Selectin Blockers And Some Of The Derivatives Showed Broad And/or Selective Inhibitory Activities Toward The E-,P-,And L-Selectins. In Addition,It Was Found That The Experimental Evidence Well Supported That The Computational Screening Using 3D-Pharmacophore Model Could Be Useful Methodology To Find Out A New Lead For The Several Type Of Selectin Blockers,Which Included A Broad And/or A Selective Inhibitor. (C) 2001 Published By Elsevier Science Ltd.
Doi:10.1016/s0968-0896(01)00023-2

专利信息

专利号:US-7189849-B2
优先权日:1997-02-10
标 题:Synthesis of acyclic nucleoside derivatives
发明人：LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY
权利人:MEDIVIR AB
摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

专利号:US-4367346-A
优先权日:1981-04-23
标 题 :Method for synthesis of long-chain alcohols
发明人：PARKER DANE K
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention is concerned with the preparation of long-chain carboxylic acids and alcohols from cyclododecanone and acyl chlorides. More specifically, this invention relates to a process for the preparation of 1-triacontanol, CH 3 (CH 2 ) 28 CH 2 OH. Triacontanol acts as a growth stimulant on a wide range of plants to increase dry weight gains, water uptake, water use efficiency and protein synthesis in treated plants.

专利号:US-4803287-A
优先权日:1986-04-16
标题 :Certain photochromic fulgide compounds and method for their synthesis
发明人：HIBINO JUNICHI; ANDO EIJI
权利人:AGENCY IND SCIENCE TECHN
摘要:The invention provides a photochromic material characterized by an improvnt in balance of the substituents in the conventional furylfulgides and represented by the general formula: ##STR1## (wherein R represents an alkyl chain having 5 to 31 carbon atoms). According to this molecular structure, a mutually appropriate steric hindrance is induced between the isopropylidence group and the long-chain alkyl group to make the regio isomer unstable, thus preventing the regio isomer from being by-produced while also inhibiting any isomerization reaction from occuring in the synthesis of the fulgide. Further, a good balance of hydrophilic part and hydrophobic part is produced to facilitate formation of a Langmuir-Blodgett film.

专利号:US-2023111600-A1
优先权日:2019-12-17
标题 :Polymeric fatty acid compounds for the treatment of fibrous amino acid-based substrates, especially hair
发明人：WAGNER ROLAND; STREICHER KATHARINA; ROHMANN LAURA; WENSKE CHRISTIAN; HAVELI SHRUTISAGAR DATTATRAYA
权利人:MOMENTIVE PERFORMANCE MAT GMBH
摘要:The present invention is directed at mono-, di- or polyquaternary ammonium compounds of the formula (I) wherein x is 1 to 50, and F can be the same or different and is represented by the general formula (II) wherein at least one of the optionally substituted and optionally functional-group-containing hydrocarbon radicals R 1 , R 2 , R 3 , R 4 or R 5 contains at least one estolide moiety comprising two or more ester or amide moieties. The invention also relates to a process for the synthesis of such compounds, the use of the compounds in cosmetic formulations for skin and hair care, cosmetic compositions for the treatment of fibers, and compositions containing one or more of the compounds for the treatment of hair.

专利号:US-2022340612-A1
优先权日:2019-09-17
标题:Synthesis of glycosphingolipids
发明人：GUO ZHONGWU; LI QINGJIANG
权利人:UNIV FLORIDA
摘要:Provided are methods of synthesizing glycolipids. The methods combine chemical and enzymatic transformations to rapidly provide diverse natural and functionalized glycolipids in a high convergent matter. Stepwise enzymatic elongation of a carbohydrate chain of a common glycolipid precursor, compound (1), provides glycan intermediates of Formula (II), using sugar-nucleotides as glycosyl donors and glycosyltransferases as enzymes. Also provided are glycan intermediates of Formula (II) and alkene intermediates of Formula (IV) and methods of preparing same.

专利号:US-2024409571-A1
优先权日:2023-06-08
标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines
发明人：CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN
权利人:UNIV CALIFORNIA
摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.