CAS: 1069-54-1; Bis-(1,2-Dimethylpropyl)Borane

📜2,3-二甲基-2-丁烯置于硼烷四氢呋喃络合物体系中,化学反应 2.0H,反应生成二(3-甲基丁烷-2-基)硼烷
参考文献: 6R-(3,6-Dideoxy-L-Arabino-Hexopyranosyloxy)Heptanoic Acid,Preparation Process For The Same And Dauer Effect Thereof[fr] Acide 6R-(3,6-Didesoxy-L-Arabino-Hexopyranosyloxy)Heptanoique,Procede De Preparation De Cet Acide Et Effet Dauer De Cet Acide
标题: 6R-(3,6-Dideoxy-L-Arabino-Hexopyranosyloxy)Heptanoic Acid,Preparation Process For The Same And Dauer Effect Thereof[fr] Acide 6R-(3,6-Didesoxy-L-Arabino-Hexopyranosyloxy)Heptanoique,Procede De Preparation De Cet Acide Et Effet Dauer De Cet Acide
摘要:本发明涉及一种从caenorhabditis Elegans中分离出的6R-(3,6-二去氧-L-阿拉伯糖基)庚酸酯素的立体化学确定,合成和抑制老化和应激的效果.利用与老化,应激,新陈代谢,体内信号传递系统以及抗癌,肥胖和抑制老化和应激的药剂相关的这种信息素,可以研发出医药物质.

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-8703952-B2
优先权日:2008-12-12
标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates
发明人：WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID
权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD
摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.

专利号:US-3954818-A
优先权日:1974-11-25
标 题:Synthesis of non-4-en-6-ynoic acid ester
发明人：LABOVITZ JEFFERY N; HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Steroselective synthesis of the sex pheromone (7E, 9Z)-7,9-dodecadien-1-yl acetate of the grape vine moth Lobesia botrana and intermediates therefor.

专利号:US-4014946-A
优先权日:1974-11-25
标 题:Synthesis of 1-bromonon-4-en-6-yne
发明人：LABOVITZ JEFFERY N; HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Steroselective synthesis of the sex pheromone (7E, 9Z)-7,9-dodecadien-1-yl acetate of the grape vine moth Lobesia botrana and intermediates therefor.