CAS: 103-56-0; Cinnamyl Propionate

相似化合物

103-59-3 103-54-8 103-36-6

上下游产品

3-Phenylpropenol propionic acid cinnamyl 2-bromopropanoate Ethyl propionate2-methyl-3-phenyl-pent-4-enoic acid 2-Benzylpyridine 2-benzyl-4-methyl pyridine 2-benzyl-6-methylpyridine

Cinnamyl 2-Bromopropanoate置于indium(III) Chloride,Indium,三甲基氯硅烷,三乙胺,乙腈体系中,用100%的收率获得丙酸桂酯
参考文献:Indium-Mediated Reformatsky-claisen Rearrangement
标题:Indium-Mediated Reformatsky-claisen Rearrangement
摘要:A New Variant Of The Reformatsky-Claisen Rearrangement Is Described. The Reaction Of Substituted Allyl Alpha-Bromoacetates With Indium And Indium(III) Chloride Under Ultrasonication Provides A General Entry Into The Functionalized Synthon. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2011.03.079

专利信息

专利号:WO-2012089181-A1
优先权日:2010-12-30
标题 :O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
发明人：VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
权利人:ZENTIVA KS; VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
摘要:The compounds of general formula II are new and represent important intermediates in the synthesis of tapentadol. In the synthesis of tapentadol of formula I and its pharmaceutically acceptable salts, O-protected (2R,3R)-acids of general formula II, in step A, are reacted in an inert organic solvent with an activating agent, optionally in presence of a catalyst or a base; in step B, the obtained compounds of general formula V, wherein R has the above mentioned meaning and X stands for chlorine or alkoxycarbonyloxyl group O-CO-OR 1 or pivaloyloxyl O-CO-t-Bu group, wherein R 1 is methyl or ethyl, are reacted with dimethylamine or its salts optionally in presence of a base; in step C, the obtained N, N-dimethylamides of general formula VI, wherein R has the above mentioned meaning, are reduced by means of hydride agents in a suitable solvent; in step D, the produced alkeneamines of general formula VII, wherein R has the above mentioned meaning, are hydrogenated on a metal catalysts in a suitable solvent; and, finally, in step E, the produced alkaneamines of general formula VIII, wherein R has the above mentioned meaning, are O-dealkylated by means of dealkylating agents, and, if required, the obtained tapentadol is converted by the action of a pharmaceutically acceptable acid to respective salts, e.g. hydrochloride.

专利号:CN-116655707-A
优先权日:2023-05-31
标 题:A kind of end group functionalized polymer catalyst and its synthesis method and application