CAS: 10199-64-1; 1-(1H-Pyrazol-1-yl)Ethan-1-One

该化合物是一种七环化合物, 其特点是与乙酰集团相连的丙烯环. 这种结构具有适合用作有机合成, 特别是制药和农用化学应用的多用途中间体的再活性. 它的双甲醇会有助于参与各种结合和功能化反应, 而乙酰集团则提供一个进一步衍生的场所. 该复合体在标准条件下表现出良好的稳定性, 便于处理和储存. 它定义明确的化学特性使得它对于建造复杂的分子结构, 包括生物活性分子具有价值. 研究人员支持它一贯地在核生殖器替代和凝聚反应方面发挥作用, 有助于高效的合成途径 .

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CAS号75-36-5 乙酰氯 | CAS号288-13-1 吡唑 | CAS号588-46-5 N-乙酰苄胺 | CAS号762-84-5 N-叔丁基乙酰胺 | CAS号288-13-1 吡唑 | CAS号79-20-9 乙酸甲酯 | CAS号103-89-9 4-甲基乙酰苯胺 | CAS号685-91-6 N,N-二乙基乙酰胺 | CAS号5331-48-6 N-正丙基乙胺 | CAS号10230-68-9 1-硝基丙烷-2-酮 | CAS号103-84-4 N-乙酰苯胺 | CAS号1118-69-0 N-异丙基乙酰胺

合成工艺路线路线简述

    📜吡唑 反应生成1-(N-乙酰基)吡唑
    参考文献:Lermer,Helmut;Hoelderich,Wolfgang;Dockner,Toni;Koehler,Hermann
    标题:Lermer,Helmut;Hoelderich,Wolfgang;Dockner,Toni;Koehler,Hermann

    专利信息


    专利号:US-4908444-A
    优先权日:1986-01-23
    标题:Method of producing cephem compounds
    发明人:NAITO KENZO; ISHIBASHI YUKIO
    权利人:TAKEDA CHEMICAL INDUSTRIES LTD
    摘要:A method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids, which are useful as antibiotics or as intermediates in the synthesis of antibiotics, by reacting a 3-hydroxymethyl-3-cephem-4-carboxylic acid with a saturated fatty acid anhydride in an aqueous medium in the presence of an acid-acceptor base and a 4-(tertiary amino)pyridine.

    专利号:WO-2019203773-A1
    优先权日:2018-04-17
    标题 :Potentially anticarcinogenic novel isoindole-1,3-dione derivatives and synthesis method for such compounds
    发明人:KARA YUNUS; KISHALI NURHAN; ÅžANLI MOHAMED GÜLÅžAH; KAYA MELTEM; KÖSE AYTEKIN
    权利人:ATATUERK UENIVERSITESI BILIMSEL ARASTIRMA PROJELERI BIRIMI
    摘要:The invention is related to novel isoindole-1,3-dione derivatives which are determined to be effective in vitro on certain cancer types (e.g., Lung, breast and cervical cancer) as well as the synthesis method of such compounds for use in the chemistry sector, pharmaceuticals industry and pharmacy sector.

    专利号:US-11820763-B2
    优先权日:2020-08-04
    标题:Bromophenol-pyrazoline compound and synthesis method and use thereof
    发明人:SHI DAYONG; LI XIANGQIAN; WANG XIN; YANG JINBO
    权利人:LEAD HIGH TECH QINGDAO CO LTD
    摘要:The present invention relates to a compound, and in particular to a bromophenol-pyrazoline compound and a synthesis method and use thereof. The bromophenol-pyrazoline compound is represented by a general structural formula below: n n n n n n n n n n The bromophenol-pyrazoline compound provided in the present invention has efficient inhibitory activity against the main protease M pro , and interferes with the replication of coronavirus in cells, indicating that the compound has the effect of treating coronavirus pneumonia and thus has a broad prospect of application in the preparation of drugs for treating coronavirus pneumonia.

    专利号:US-5162522-A
    优先权日:1988-08-10
    标 题:Method for producing cephem compounds
    发明人:NAITO KENZO; ISHIBASHI YUKIO; FUJITANI TOSHIHIKO
    权利人:TAKEDA CHEMICAL INDUSTRIES LTD
    摘要:A method for producing 3-(3-oxobutyryloxymethyl)-3-cepham-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and in good yield, characterized by reacting a 3-hydroxylmethyl-3-cephem-4-carboxylic acid with diketene in the presence of a 4-(tertiary-amino)pyridine and if necessary, when a 7-acylamino-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid is obtained, subjecting it to deacylation at the 7-position thereof.

    专利号:EP-0458932-A1
    优先权日:1989-12-12
    标 题:Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase

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    合成参考文献


    参考文献:10.1107/s1600536810025584
    摘要:Jasinski JP, Pek AE, Samshuddin S, Narayana B, Yathirajan HS. 1-[3,5-Bis(4-chloro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 07;66(Pt 8):o1950–1.
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