专利号:US-4908444-A 优先权日:1986-01-23 标题:Method of producing cephem compounds 发明人:NAITO KENZO; ISHIBASHI YUKIO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:A method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids, which are useful as antibiotics or as intermediates in the synthesis of antibiotics, by reacting a 3-hydroxymethyl-3-cephem-4-carboxylic acid with a saturated fatty acid anhydride in an aqueous medium in the presence of an acid-acceptor base and a 4-(tertiary amino)pyridine.
专利号:WO-2019203773-A1 优先权日:2018-04-17 标题 :Potentially anticarcinogenic novel isoindole-1,3-dione derivatives and synthesis method for such compounds 发明人:KARA YUNUS; KISHALI NURHAN; ÅžANLI MOHAMED GÜLÅžAH; KAYA MELTEM; KÖSE AYTEKIN 权利人:ATATUERK UENIVERSITESI BILIMSEL ARASTIRMA PROJELERI BIRIMI 摘要:The invention is related to novel isoindole-1,3-dione derivatives which are determined to be effective in vitro on certain cancer types (e.g., Lung, breast and cervical cancer) as well as the synthesis method of such compounds for use in the chemistry sector, pharmaceuticals industry and pharmacy sector.
专利号:US-11820763-B2 优先权日:2020-08-04 标题:Bromophenol-pyrazoline compound and synthesis method and use thereof 发明人:SHI DAYONG; LI XIANGQIAN; WANG XIN; YANG JINBO 权利人:LEAD HIGH TECH QINGDAO CO LTD 摘要:The present invention relates to a compound, and in particular to a bromophenol-pyrazoline compound and a synthesis method and use thereof. The bromophenol-pyrazoline compound is represented by a general structural formula below: n n n n n n n n n n The bromophenol-pyrazoline compound provided in the present invention has efficient inhibitory activity against the main protease M pro , and interferes with the replication of coronavirus in cells, indicating that the compound has the effect of treating coronavirus pneumonia and thus has a broad prospect of application in the preparation of drugs for treating coronavirus pneumonia.
专利号:US-5162522-A 优先权日:1988-08-10 标 题:Method for producing cephem compounds 发明人:NAITO KENZO; ISHIBASHI YUKIO; FUJITANI TOSHIHIKO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:A method for producing 3-(3-oxobutyryloxymethyl)-3-cepham-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and in good yield, characterized by reacting a 3-hydroxylmethyl-3-cephem-4-carboxylic acid with diketene in the presence of a 4-(tertiary-amino)pyridine and if necessary, when a 7-acylamino-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid is obtained, subjecting it to deacylation at the 7-position thereof.
专利号:EP-0458932-A1 优先权日:1989-12-12 标 题:Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase