CAS: 99-31-0; 5-Aminoisophthalic Acid

上下游产品

5-硝基异酞酸 5-Nitrobenzene-1,3-Dicarboxylic Acid 618-88-2

5-硝基异酞酸置于palladium On Activated Charcoal 氢气体系中,化学反应生成 5-氨基间苯二甲酸
参考文献:Selective Hydrogenolysis Of Bis(Hydroxymethyl)Aromatic Compounds
标题:Selective Hydrogenolysis Of Bis(Hydroxymethyl)Aromatic Compounds
摘要:在碱性溶液中,采用raney镍对对称双(羟甲基)芳香化合物进行选择性氢解,温度为20°C,时间为24至36小时.对应单氢解产物的产率在75%至96%之间.通过合成4-(溴甲基)苯甲酸,展示了该反应的实用性.
DOI:10.1055/s-1992-26346

专利信息

专利号:US-2008146772-A1
优先权日:2006-11-02
标题 :Materials and methods for co-crystal controlled solid-state synthesis of imides and imines
发明人：ZAWOROTKO MICHAEL J; CHENEY MIRANDA L
权利人:UNIV SOUTH FLORIDA
摘要:The subject invention pertains to methods for solid-state synthesis of imides and imines using co-crystals. The co-crystal formers utilized are substrates of condensation reactions and co-crystals can be obtained in high yield via methods such as slurrying, solvent evaporation, solvent crystallization, treatment with supercritical fluid(s), melting plus crystallization, slurry conversion, grinding of solids, blending of powders, heating of solids, solvent-drop grinding, or grinding plus melting.

专利号:US-5817861-A
优先权日:1996-03-29
标题 :Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media
发明人：VILLA MARCO; NARDI ANTONIO; PAIOCCHI MAURIZIO
权利人:BRACCO INT BV
摘要:A process for the preparation of (S)-N,N'-bis 2-hydroxy-1-(hydroxymethyl)ethyl!-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalamide, an intermediate useful for the synthesis of iopamidol, by reaction between L-5-(2-acetoxy-propionylamino)-2,4,6-triiiodoisophthaloyl dichloride and 2-amino-1 ,3-propanediol in N-methylpyrrolidone and in the presence of a base, is described.

专利号:US-9157156-B2
优先权日:2009-07-07
标题 :Process for the preparation of a iodinating agent
发明人：ANELLI PIER LUCIO; VISCARDI CARLO FELICE; DELOGU PIETRO; GOFFREDI FABRIZIO; NARDELLI ALFONSO; GIOVENZANA GIOVANNI BATTISTA
权利人:ANELLI PIER LUCIO; VISCARDI CARLO FELICE; DELOGU PIETRO; GOFFREDI FABRIZIO; NARDELLI ALFONSO; GIOVENZANA GIOVANNI BATTISTA; BRACCO IMAGING SPA
摘要:The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.

专利号:US-9006345-B2
优先权日:2011-03-25
标题 :Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
发明人：LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J
权利人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J; UNIV COLUMBIA
摘要:In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.

专利号:US-6737541-B2
优先权日:2000-01-26
标题 :Preparation of nitrogen mustard derivatives
发明人：SIEDLECKI PAUL STANISLAW; GLANVILLE MARTIN DAVID MICHAEL
权利人:ASTRAZENECA AB
摘要:This invention relates to an improved synthesis of 5-(N-[(S)-N-{N,N-bis( 2-chloroethyl)amino}phenoxycarbonyl)-gamma-glutamyl]amino)isophthalic acid (also named ZD9063P), a prodrug used in Antibody Directed Enzyme Prodrug Therapy (ADEPT), a targeted cytotoxic cancer therapy. Another aspect of the invention comprises a compound of Formula (I) in which R<1 >and R<2 >are chloro, R<3 >is an alphamethylbenzylamine salt of carboxylic acid, (R<4>)n represents a benzyl protected 3,5-dicarboxylic acid and the asterisked chiral carbon in Formula (I) has S configuration, preferably in crystalline form.

专利号:US-9382194-B2
优先权日:2011-10-31
标 题:Iodination process for the preparation of 3, 5-disubstituted-2, 4, 6-triiodo aromatic amines compounds
发明人：XING HONGDENG; LI LEI; HU ZHIQI
权利人:XING HONGDENG; LI LEI; HU ZHIQI; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:The invention discloses a improved process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein R 1 and R 2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.