CAS: 98027-84-0; 2,6-Dichloro-4-Iodopyridine

• 英文名称2,6-Dichloro-4-Iodopyridine
• 中文名称2,6-二氯-4-碘吡啶
• IUPAC名称2,6-dichloro-4-iodopyridine
• 其它别名2,6-Dichloro-4-iodopyridine
• CAS编号98027-84-0
• MFCD编号:MFCD07368400
• EINECS号:627-336-6
• 分子式:C5H2Cl2IN
• 分子量:273.89
• 产品CID: 2024144
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: NGSKFMPSBUAUNE-UHFFFAOYSA-N
• InChI=1S/C5H2Cl2IN/c6-4-1-3(8)2-5(7)9-4/h1-2H…
• 计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

物理性质

• 熔点161-165°C
• 沸点291.6°C at 760 mmHg
• 闪点130.145°C
• 密度2.1±0.1 g/cm3
• pKa:-3.19±0.10(预测)
• PSA:12.89
• LogP:2.993
• 折射率1.652
• 蒸汽压0.0±0.6 mmHg at 25°C
• 敏感性光敏感
• 外观形态白色至灰色至棕色粉末至结晶性
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用该化合物用于聚代.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05;
  注释: Exclamation mark & Corrosion
• 危险类别急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  皮肤致敏 类别1
  严重眼刺激 类别2
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H317 |可能引起皮肤过敏反应.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• 危险等级8
• UN编号1759.0
• 危险品标志Xn
• 包装等级Ⅲ
• 安全声明26-36-36/37/39
• 危险类别码22-37/38-41-43
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 2402-78-0 = 98027-84-0
  反应条件:1.1 Reagents: Magnesate(1-),Dichloro(2,2,6,6-Tetramethylpiperidinato)-,Lithium (1:1) Solvents: Tetrahydrofuran; 0.1 H,25 °C1.2 Reagents: Iodine Solvents: Tetrahydrofuran1.3 Reagents: Iodine Solvents: Tetrahydrofuran; -30 °C1.4 Reagents: Ammonium Chloride Solvents: Water
  标题:Mixed Mg/li Amides Of The Type R2Nmgcl.Licl As Highly Efficient Bases For The Regioselective Generation Of Functionalized Aryl And Heteroaryl Magnesium Compounds
  作者:Krasovskiy,Arkady; Krasovskaya,Valeria; Knochel,Paul
  参考文献:Angewandte Chemie 日期:2006 卷标:45(18) 页码:2958-2961]
  
  2402-78-0 = 98027-84-0
  反应条件:1.1 Reagents: Magnesate(1-),Dichloro(2,2,4,6,6-Pentamethyl-1-Piperidinyl)-,Lithium (1:1) Solvents: Tetrahydrofuran; 25 °C; 10 Min,25 °C1.2 Reagents: Iodine; 25 °C1.3 Reagents: Ammonium Chloride Solvents: Water; 25 °C
  标题:New Mixed Li/mg And Li/mg/zn Amides For The Chemoselective Metalation Of Arenes And Heteroarenes
  作者:Rohbogner,Christoph J.; Wunderlich,Stefan H.; Clososki,Giiuliano C.; Knochel,Paul
  参考文献:European Journal Of Organic Chemistry (2009 日期:2009 页码:1781-1795]
  
  591-50-4 + 42521-08-4 = 98027-84-0 + 98-88-4
  反应条件:1.1 Catalysts: Tris(Dibenzylideneacetone)Dipalladium,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: O-Xylene; 12 H,150 °C; 150 °C -> Rt1.2 Reagents: Methanol; 30 Min,45 °C
  标题:Metathesis-Active Ligands Enable A Catalytic Functional Group Metathesis Between Aroyl Chlorides And Aryl Iodides
  作者:Lee,Yong Ho; Morandi,Bill
  参考文献:Nature Chemistry (2018 日期:2018 卷标:10(10) 页码:1016-1022]
  
  2402-78-0 = 98027-84-0 + 148493-37-2
  反应条件:1.1 Reagents: Magnesate(1-),Tris(2,2,6,6-Tetramethyl-1-Piperidinyl)-,Lithium Solvents: Diethyl Ether; 2 H,-10 °C1.2 Reagents: Iodine1.3 Reagents: Water
  标题:Deprotonation Of Chloropyridines Using Lithium Magnesates
  作者:Awad,Hacan; Mongin,Florence; Trecourt,Francois; Queguiner,Guy; Marsais,Francis
  参考文献:Tetrahedron Letters (2004 日期:2004 卷标:45(42) 页码:7873-7877]
  
  2402-78-0 = 98027-84-0 + 148493-37-2 + 1182718-72-4
  反应条件:1.1 Reagents: Butyllithium,2,2,6,6-Tetramethylpiperidine,(T-4)-Dichloro(N1,N1,N2,N2-Tetramethyl-1,2-Ethanediamine-Kn1,Kn2)Cadmium Solvents: Tetrahydrofuran,Hexane; 15 Min,0 °C1.2 2 H,Rt1.3 Reagents: Iodine Solvents: Tetrahydrofuran; Overnight,Rt
  标题:Deprotonative Metalation Of Chloro- And Bromopyridines Using Amido-Based Bimetallic Species And Regioselectivity-Computed Ch Acidity Relationships
  作者:Snegaroff,Katia; Nguyen,Tan Tai; Marquise,Nada; Halauko,Yury S.; Harford,Philip J.; Et Al
  参考文献:Chemistry - A European Journal (2011 日期:2011 卷标:17(47) 页码:13284-13297]
  
  2402-78-0 = 98027-84-0
  反应条件:1.1 Reagents: Di-μ-Chlorobis(Tetrahydrofuran)[(Tetrahydrofuran)(2,2,6,6-Tetramethyl-1-Piperidi...; 1 H,Rt1.2 Reagents: Iodine; -30 °C
  标题:Ground- And Excited-State Properties Of Iron(Ii) Complexes Linked To Organic Chromophores
  作者:Dierks,Philipp; Paepcke,Ayla; Bokareva,Olga S.; Altenburger,Bjoern; Reuter,Thomas; Et Al
  参考文献:Inorganic Chemistry (2020 日期:2020 卷标:59(20) 页码:14746-14761]
  
  148493-37-2 = 98027-84-0
  反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran,Hexane1.2 Reagents: Water
  标题:Strategies For The Selective Functionalization Of Dichloropyridines At Various Sites
  作者:Marzi,Elena; Bigi,Anna; Schlosser,Manfred
  参考文献:European Journal Of Organic Chemistry (2001 日期:2001 页码:1371-1376]
  
  2402-78-0 = 98027-84-0
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 Min,-75 °C1.2 Reagents: Iodine Solvents: Tetrahydrofuran; 15 Min,-75 °C1.3 Reagents: Sodium Sulfite Solvents: Water
  标题:Regiochemically Flexible Substitutions Of Di-,Tri-,And Tetrahalopyridines: The Trialkylsilyl Trick
  作者:Schlosser,Manfred; Bobbio,Carla; Rausis,Thierry
  参考文献:Journal Of Organic Chemistry (2005 日期:2005 卷标:70(7) 页码:2494-2502]
  
  5398-44-7 = 98027-84-0
  反应条件:1.1 Reagents: N-Iodosuccinimide,Pyridinium,1-Fluoro-2,4,6-Trimethyl-,Tetrafluoroborate(1-) (1:1) Catalysts: Tetrakis(Acetonitrile)Copper(1+) Tetrafluoroborate Solvents: Acetonitrile; 4 H,30 °C
  标题:Unified Approach To Decarboxylative Halogenation Of (Hetero)Aryl Carboxylic Acids
  作者:Chen,Tiffany Q.; Pedersen,P. Scott; Dow,Nathan W.; Fayad,Remi; Hauke,Cory E.; Et Al
  参考文献:Journal Of The American Chemical Society (2022 日期:2022 卷标:144(18) 页码:8296-8305]
  
  2587-02-2 = 98027-84-0
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water1.2 Reagents: Sodium Nitrite Solvents: Water1.3 Reagents: Potassium Iodide Solvents: Water1.4 Reagents: Sodium Bicarbonate Solvents: Tetrahydrofuran
  标题:Convenient Synthesis And Transformation Of 2,6-Dichloro-4-Iodopyridine
  作者:Mello,Jesse V.; Finney,Nathaniel S.
  参考文献:Organic Letters (2001 日期:2001 卷标:3(26) 页码:4263-4265]
  
  2402-78-0 = 98027-84-0
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 H,-75 °C1.2 Reagents: Iodine,Sodium Thiosulfate Solvents: Tetrahydrofuran,Water; 15 H,-75 °C
  标题:Synthetic,Optical And Theoretical Study Of Alternating Ethylenedioxythiophene-Pyridine Oligomers: Evolution From Planar Conjugated To Helicoidal Structure Towards A Chiral Configuration
  作者:Chevallier,Floris; Charlot,Marina; Mongin,Florence; Champagne,Benoit; Franz,Edith; Et Al
  参考文献:Chemphyschem (2016 日期:2016 卷标:17(24) 页码:4090-4101]
  
  2587-02-2 = 98027-84-0
  反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Acetonitrile,Water; 0 °C; 5 Min,0 °C1.2 Reagents: Potassium Iodide Solvents: Water; 0 °C; 0 °C -> Rt
  标题:Exploiting The Versatile Assembly Of Arylpyridine Fluorophores For Wavelength Tuning And Sar
  作者:Fang,Albert G.; Mello,Jesse V.; Finney,Nathaniel S.
  参考文献:Organic Letters (2003 日期:2003 卷标:5(7) 页码:967-970]
  
  2402-78-0 = 98027-84-0
  反应条件:1.1 Reagents: Methyllithium Solvents: Diethyl Ether,Tetrahydrofuran; 5 Min,0 °C1.2 Reagents: Boron Trifluoride Etherate Solvents: Toluene; 20 Min,0 °C1.3 Reagents: Magnesate(1-),Dichloro(2,2,6,6-Tetramethylpiperidinato)-,Lithium (1:1); 3 H,0 °C1.4 Reagents: Iodine Solvents: Tetrahydrofuran; 10 Min,25 °C1.5 Reagents: Acetic Acid Solvents: Dimethyl Sulfoxide,Acetonitrile
  标题:Selective Functionalization Of Complex Heterocycles Via An Automated Strong Base Screening Platform
  作者:Boga,Sobhana Babu; Christensen,Melodie; Perrotto,Nicholas; Krska,Shane W.; Dreher,Spencer; Et Al
  参考文献:Reaction Chemistry & Engineering (2017 日期:2017 卷标:2(4) 页码:446-450]
  
  2402-78-0 = 98027-84-0 + 148493-37-2
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -75 °C; 45 Min,-75 °C1.2 Reagents: Iodine Solvents: Tetrahydrofuran; -75 °C; 15 Min,-75 °C; -75 °C -> Rt
  标题:Intermolecular Contacts In The Crystal Structures Of Specifically Varied Halogen And Protonic Group Substituted Azines
  作者:Huebscher,Joerg; Seichter,Wilhelm; Weber,Edwin
  参考文献:Crystengcomm (2017 日期:2017 卷标:19(22) 页码:3026-3036]
  
  2402-78-0 = 98027-84-0 + 148493-37-2
  反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 Min,-75 °C1.2 Reagents: Iodine Solvents: Tetrahydrofuran; -75 °C; 15 Min,-75 °C; -75 °C -> Rt1.3 Reagents: Sodium Thiosulfate Solvents: Water; Rt
  标题:Synthesis And Structural Characterization Of Ethynylene-Bridged Bisazines Featuring Various α-Substitution
  作者:Huebscher,Joerg; Seichter,Wilhelm; Gruber,Thomas; Kortus,Jens; Weber,Edwin
  参考文献:Journal Of Heterocyclic Chemistry (2015 日期:2015 卷标:52(4) 页码:1062-1074

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
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