CAS: 879-65-2; 2-Quinoxalinecarboxylic Acid

该化合物是一种杂交有机化合物,其特点是五氧基芯,在2号位置有一个箱式酸功能组,这种结构在合成化学中具有多功能性,特别是作为制药,农用化学品和协调综合体的构件.它的僵硬芳香框架和反应式盒式组能够有效地衍生,促进生物活性分子的开发.该复合体在标准条件下表现出稳定性,与各种组合和凝聚反应相容.其效用扩大到物质科学的应用,在材料科学中,它作为功能化聚合物和离心体的前体.高纯度可满足严格的研究和工业要求.

结构式图片

相似化合物

1865-11-8 1593-08-4 41242-94-8

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号7065-23-8 2-喹喔啉羧酸乙酯 | CAS号7251-61-8 2-甲基喹喔啉 | CAS号4711-06-2 (1R,2S,3R)-1-qu... | CAS号1593-08-4 2-喹喔啉甲醛 | CAS号80840-09-1 1-(2-喹喔啉基)-1,2,... | CAS号95-54-5 邻苯二胺(OPD) | CAS号36680-17-8 2-styrenylquino... | CAS号2379-55-7 2,3-二甲基喹戊啉 | CAS号91-19-0 喹喔啉 | CAS号54745-92-5 2-喹喔啉甲酰氯 | CAS号91-19-0 喹喔啉 | CAS号7065-23-8 2-喹喔啉羧酸乙酯 | CAS号7483-33-2 2-喹噁啉甲腈 | CAS号1865-11-8 喹喔啉-2-甲酸甲酯 | CAS号27739-37-3 2,2'-Biquinoxaline | CAS号7066-32-2 N-benzyl-3,6,6-... | CAS号54571-06-1 喹喔啉-2-甲酰肼 | CAS号5182-90-1 2-喹喔啉甲酰胺

合成工艺路线路线简述

  • 合成目标产物 2-Quinoxalinecarboxylic Acid 主要起始原料 O-Phenylenediamine
  • 34572-71-9 = 879-65-2
    反应条件:1.1 Reagents: Hydrochloric Acid
    标题:Certain Properties Of 1-Oxo-4-Hydroxypyridazino[4,5-6]Quinoxaline
    作者:Koksharova,T. G.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1977 卷标:(3) 页码:402-6]

    7251-61-8 = 879-65-2
    反应条件:1.1 Reagents: Benzyl Alcohol Solvents: Glycerol1.2 Reagents: Ammonium Sulfate,Ammonium Chloride
    标题:Biocatalytic Oxidation Of 2-Methylquinoxaline To 2-Quinoxalinecarboxylic Acid
    作者:Wong,John W.; Et Al
    参考文献:Organic Process Research & Development 日期:2002 卷标:6(4) 页码:477-481]

    1593-08-4 = 879-65-2
    反应条件:1.1 Reagents: Hydrochloric Acid,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Pyridine,Water; 12 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 9
    标题:Development Of Reference Materials Of 2-Quinoxalinecarboxylic Acid
    作者:Zhou,Bo; Et Al
    参考文献:Huaxue Shiji 日期:2016 卷标:38(1) 页码:55-58]

    1593-08-4 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water
    标题:Biocatalytic Oxidation Of 2-Methylquinoxaline To 2-Quinoxalinecarboxylic Acid
    作者:Wong,John W.; Et Al
    参考文献:Organic Process Research & Development 日期:2002 卷标:6(4) 页码:477-481]

    36680-17-8 = 879-65-2
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone
    标题:An Efficient Synthesis Of 2-Quinoxalinecarboxylic Acid
    作者:Harms,Arthur E.
    参考文献:Organic Process Research & Development 日期:2004 卷标:8(4) 页码:666-669]

    2819641-97-7 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 40 °C; 40 °C -> 60 °C; 3 H,60 °C; 60 °C; 30 Min,60 °C; 30 Min,60 °C -> Reflux; Reflux -> 80 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 18 H,Acidified,4 °C
    标题:Microscale Parallel Synthesis Of Acylated Aminotriazoles Enabling The Development Of Factor Xiia And Thrombin Inhibitors
    作者:Platte,Simon; Et Al
    参考文献:Chemmedchem 日期:2021 卷标:16(24) 页码:3672-3690]

    80840-09-1 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 45 Min,40 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 15 Min,40 °C; 3 H,40 °C -> 60 °C; 30 Min,60 °C; 45 Min,60 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
    标题:Quinoxaline-2-Carboxamides. Synthesis And Pharmacological Evaluation As Serotonin Type-3 (5-Ht3) Receptor Antagonists
    作者:Mahesh,Radhakrishnan; Et Al
    参考文献:Journal Of Enzyme Inhibition And Medicinal Chemistry 日期:2011 卷标:26(5) 页码:610-615]

    = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide; 1 H,80 °C
    标题:An Efficient Synthesis And Biological Activity Of Quinoxaline-2-Carboxylic Acid And Its Derivatives
    作者:Kumar,Navneet; Et Al
    参考文献:Journal Of Applicable Chemistry (Lumami 日期:2013 卷标:2(2) 页码:143-149]

    57-48-7 = 879-65-2
    反应条件:1.1 Reagents: Acetic Acid Solvents: Water; 80 °C1.2 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 60 °C
    标题:Aromatic Heterocyclic Esters Of Podophyllotoxin Exert Anti-Mdr Activity In Human Leukemia K562/adr Cells Via Ros/mapk Signaling Pathways
    作者:Zhang,Lei; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2016 卷标:123 页码:226-235]

    57-48-7 = 879-65-2
    反应条件:1.1 Solvents: Acetic Acid; Rt -> 80 °C; 18 H,80 °C; 80 °C -> Rt; 4 H,Rt -> 4 °C2.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 40 °C; 40 °C -> 60 °C; 3 H,60 °C; 60 °C; 30 Min,60 °C; 30 Min,60 °C -> Reflux; Reflux -> 80 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; 18 H,Acidified,4 °C
    标题:Microscale Parallel Synthesis Of Acylated Aminotriazoles Enabling The Development Of Factor Xiia And Thrombin Inhibitors
    作者:Platte,Simon; Et Al
    参考文献:Chemmedchem 日期:2021 卷标:16(24) 页码:3672-3690]

    7483-33-2 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 12 H,110 °C
    标题:Water-Mediated C-H Cyanation Of Quinoxalin-2(1H)-Ones And Quinoxalines Under Visible-Light Conditions
    作者:Badhani,Gaurav; Et Al
    参考文献:Chemistryselect 日期:2023 卷标:8(27)]

    5182-90-1 = 879-65-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; Reflux
    标题:An Efficient Synthesis Of 2-Quinoxalinecarboxylic Acid
    作者:Harms,Arthur E.
    参考文献:Organic Process Research & Development 日期:2004 卷标:8(4) 页码:666-669]

    4711-06-2 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 45 Min,40 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 0.25 H,40 °C; 3 H,40 °C -> 60 °C; 0.75 H,60 - 91 °C; 0.5 H; 0.25 H,Reflux; Reflux -> 80 °C; 80 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Overnight,Ph 2,Rt
    标题:An Efficient Synthesis Of 2-Quinoxalinecarboxylic Acid
    作者:Harms,Arthur E.
    参考文献:Organic Process Research & Development 日期:2004 卷标:8(4) 页码:666-669]

    4711-06-2 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 3 H,60 °C; 2 H,90 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Antidepressant And Anxiolytic-Like Effects Of 4N,A Novel 5-Ht3 Receptor Antagonist Using Behaviour Based Rodent Models
    作者:Kumar,Baldev; Et Al
    参考文献:Indian Journal Of Experimental Biology 日期:2012 卷标:50(9) 页码:625-632]

    4711-06-2 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 3 H,60 °C; 2 H,90 °C1.2 Reagents: Hydrochloric Acid
    标题:Design,Synthesis And Structure-Activity Relationship Of Novel Quinoxalin-2-Carboxamides As 5-Ht3 Receptor Antagonists For The Management Of Depression
    作者:Mahesh,Radhakrishnan; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(22) 页码:6773-6776]

    80840-09-1 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 3 H,60 °C; 2 H,90 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Effect Of A Novel 5-Ht3 Receptor Antagonist N-(3-Chloro-2-Methylphenyl) Quinoxalin-2-Carboxamide,In Corticosterone-Induced Depression-Like Behavior And Oxidative Stress In Mice
    作者:Gupta,Deepali; Et Al
    参考文献:Steroids 日期:2015 卷标:96 页码:95-102]

    2379-55-7 = 879-65-2
    反应条件:1.1 Reagents: Selenium Dioxide Solvents: Xylene
    标题:Oxidation Of 2,3-Dimethylquinoxaline And 2,4-Dimethylquinazoline With Selenium Dioxide
    作者:Kepez,Mustafa
    参考文献:Monatshefte Fuer Chemie 日期:1989 卷标:120(2) 页码:127-30]

    32065-66-0 = 879-65-2
    反应条件:1.1 Reagents: Sodium Dithionite Solvents: Ethanol,Water1.2 Reagents: Hydrochloric Acid Solvents: Water1.3 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water
    标题:Biocatalytic Oxidation Of 2-Methylquinoxaline To 2-Quinoxalinecarboxylic Acid
    作者:Wong,John W.; Et Al
    参考文献:Organic Process Research & Development 日期:2002 卷标:6(4) 页码:477-481]

    32065-66-0 = 879-65-2
    反应条件:1.1 Reagents: Titanium Chloride (Ticl3)2.1 Reagents: Hydrogen Peroxide
    标题:Determination Of Carbadox-Related Residues In Swine Liver By Gas Chromatography/mass Spectrometry With Ion Trap Detection
    作者:Lynch,Martin J.; Et Al
    参考文献:Journal - Association Of Official Analytical Chemists 日期:1991 卷标:74(4) 页码:611-18]

    57-48-7 = 879-65-2
    反应条件:1.1 Reagents: Acetic Acid Solvents: Water; Heated1.2 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 60 °C
    标题:Acetonitrile-Vapor-Induced Color And Luminescence Changes In A Cyclometalated Heteroleptic Iridium Complex
    作者:Liu,Zhiwei; Et Al
    参考文献:Inorganic Chemistry 日期:2008 卷标:47(18) 页码:8025-8030]

    7251-61-8 + 100-52-7 = 879-65-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Acetic Anhydride; 18 H,125 °C2.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone
    标题:An Efficient Synthesis Of 2-Quinoxalinecarboxylic Acid
    作者:Harms,Arthur E.
    参考文献:Organic Process Research & Development 日期:2004 卷标:8(4) 页码:666-669]

    434318-22-6 = 879-65-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water2.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water
    标题:Biocatalytic Oxidation Of 2-Methylquinoxaline To 2-Quinoxalinecarboxylic Acid
    作者:Wong,John W.; Et Al
    参考文献:Organic Process Research & Development 日期:2002 卷标:6(4) 页码:477-481]

    4746-10-5 = 879-65-2
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Ethanol,Water1.2 -2.1 Reagents: Sodium Hydroxide Solvents: Water; 45 Min,40 °C2.2 Reagents: Hydrogen Peroxide Solvents: Water; 0.25 H,40 °C; 3 H,40 °C -> 60 °C; 0.75 H,60 - 91 °C; 0.5 H; 0.25 H,Reflux; Reflux -> 80 °C; 80 °C -> Rt2.3 Reagents: Hydrochloric Acid Solvents: Water; Overnight,Ph 2,Rt
    标题:An Efficient Synthesis Of 2-Quinoxalinecarboxylic Acid
    作者:Harms,Arthur E.
    参考文献:Organic Process Research & Development 日期:2004 卷标:8(4) 页码:666-669]

    = 879-65-2
    反应条件:1.1 Solvents: Water; 2 H,Reflux2.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide; 1 H,80 °C
    标题:An Efficient Synthesis And Biological Activity Of Quinoxaline-2-Carboxylic Acid And Its Derivatives
    作者:Kumar,Navneet; Et Al
    参考文献:Journal Of Applicable Chemistry (Lumami 日期:2013 卷标:2(2) 页码:143-149
📜2,3-二甲基喹喔啉置于selenium(Iv) Oxide体系中,用 Xylene 作为反应溶剂,化学反应 8.0H,以40%的收率获得产物2-喹喔啉羧酸
参考文献:Zur Oxydation Von 2,3-Dimethylchinoxalin Und 2,4-Dimethylchinazolin Mit Selendioxid
标题:Zur Oxydation Von 2,3-Dimethylchinoxalin Und 2,4-Dimethylchinazolin Mit Selendioxid
摘要:
DOI:10.1007/bf00808754

海关参考信息

专利信息


专利号:US-4866175-A
优先权日:1966-11-08
标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides
发明人：ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
权利人:RESEARCH CORP
摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.

专利号:US-2023405565-A1
优先权日:2022-06-21
标 题:Catalyst composition for biaryl synthesis by decarboxylative cross-coupling
发明人：LIM CHERN-HOOI; QIAN GANG; ELDER WILLIAM ZACHARY; RILEY PAIGE; KOLVENBACH ROBIN; WALTER PHILIPP; GOCK MICHAEL
权利人:HERAEUS DEUTSCHLAND GMBH & CO KG; NEW IRIDIUM INC
摘要:The present invention relates to a catalyst composition for synthesis of heteroaromatic biaryls by a light-assisted decarboxylative carbon-carbon cross-coupling reaction, wherein the composition comprises(i) a palladium compound which is selected from a palladium salt or a palladium complex or a mixture thereof,(ii) at least one of the following compounds:a compound of Formula (I)a compound of Formula (II)an iridium complex comprising ligands L1, L2 and L3, wherein the ligands L1, L2 and L3 are selected, independently from each other, from a phenylpyridine and a bipyridine.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4388310-A
优先权日:1982-03-01
标 题:6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids
发明人：CHRISTENSEN BURTON G; DININNO FRANK P; MUTHARD DAVID A; RATCLIFFE RONALD W
权利人:MERCK & CO INC
摘要:Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: I wherein: R1 is H or acyl; R2 is hydrogen or methoxyl; R3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.

专利号:US-3767657-A
优先权日:1971-03-31
标 题 :Process for the preparation of quinoxaline di n oxides
发明人：ROBERTSON R; KASUBICK R
权利人:PFIZER
摘要:IMPROVED SYNTHESIS OF ESTERS OF 2-QUINOXALINECARBOXYLIC ACID-1,4-DIOXIDES THROUGH A CONDENSATION OF A BENZOFUROXAN AND B-KETOESTER IN THE PRESENCE OF A CATALYTIC AMOUNT OF CALCIUM HYDROXIDE, AT A TEMPERATURE OF 40-80*C.

专利号:US-2004072738-A1
优先权日:2000-12-21
标 题 :Analogues of thiocoraline and be-22179
发明人：BOGER DALE L
摘要:A process for the total synthesis of thiocoraline and BE-22179 establishes the relative and absolute stereochemistry of these compounds and enables the construction and characterization of a series of related analogues. The mechanism for the bioactivity of thiocoraline, BE-22179 and their related analogues is charaterized. Thiocoraline, BE-22179, and their related analogues are disclosed to bind to DNA by high-affinity bisintercalation and are disclosed to exhibit exceptional cytotoxic activity.

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合成参考文献


摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 396.
摘要:N. K. Dutt, G. S. Sanyal and K. Nag, J. Indian Chem. Soc. 45, 334 (1968).
摘要:W. F. Gum and M. M. Joullie, J. Org. Chem. 30, 3982 (1965).
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