专利号:US-9700543-B2 优先权日:2011-05-31 标题 :GLP-1 receptor stabilizers and modulators 发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; BRAHMACHARY ENUGURTHI; YEAGER ADAM RICHARD 权利人:CELGENE INT II SÀRL 摘要:Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1(7-36), GLP-1(9-36), oxyntomodulin and exendin variants.
专利号:CN-116082246-B 优先权日:2022-12-31 标 题 :A kind of synthesis method of ethylene thiourea derivatives
参考文献:10.1007/s11030-024-11024-2 摘要:Wu J, Yue H, Wang X, Yao Y, Du N, Gong P. Structure-based design and synthesis of novel FXIa inhibitors targeting the S2' subsite for enhanced antithrombotic efficacy. Mol Divers. 2025 Oct;29(5):4131–58. doi: 10.1007/s11030-024-11024-2.