该化合物是来自植物,特别是Strophanthus genus genus quinas的种子,特别是Strophenthus gratuts的种子的心脏晶体,众所周知,它能够抑制Na+/K+ATPase酶,导致细胞内钠和钙浓度增加,最终增加心脏萎缩性;Trophandhidin展示了一种结构,其特点是带有乳腺环的类固醇核,有助于其生物活动;它通常用于药物研究,在治疗心脏病方面具有历史意义,尽管其临床用途由于提供更安全的替代品而减少;该化合物在有机溶剂中溶解,但水溶性有限;Strophandhidin在浓度较高时可产生毒性效应,需要小心处理和剂量调节;其致癌性和动态受到各种因素的影响,包括它与其他药物的相互作用及其代谢途径;与所有心脏外形相缘相一样,监测对于避免不利影响至关重要,特别是在有基本健康状况的病人中.
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于甲醇,硫酸,水体系中,化学反应生成 毒毛旋花子苷元 参考文献:Die Glykoside Von Erysimum Crepidifolium Hgl Reichenbach.糖苷和aglykone 169. 标题:Die Glykoside Von Erysimum Crepidifolium Hgl Reichenbach.糖苷和aglykone 169. 摘要:Die Samen Von Erysimum Crepidifolium Reichenb.lieferten Nach Fermentierung Ein Glykosidgemisch,在papierchromatogrammen(teilweise Erst Nachpräparativeranreicherung)中的dem Sich中.21 Kedde阳性stoffe(a,B,C,D,F,G,H,I,J,O,P,Q,R,S,T,U,V,W,X,Y,Z)nachweisen谎言.在kristallen Sowie Einer(z)中的kristallen Sowie Einer(z)中的aufpräparativemwege Konnten Davon 8 Stoffe(b,C,D,F,G,H,I和j)以isoliert Werden的形式出现.apur Kedde的spuren DOI:10.1002/hlca.19570400105
专利号:US-5679773-A 优先权日:1995-01-17 标题 :Reagants and methods for immobilized polymer synthesis and display 发明人:HOLMES CHRISTOPHER P 权利人:AFFYMAX TECH NV 摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.
专利号:US-3595883-A 优先权日:1969-06-16 标 题 :Process for the preparation of 14beta-hydroxy - 17 -keto - 15 - androstenes and novel intermediates produced thereby 发明人:AFONSO ADRIANO 权利人:SCHERING CORP 摘要:14B-HYDROPEROXY-15-ANDROSTEN-17-ONES, PREPARED BY THE ACTION OF OXYGEN ON 14-ANDROSTEN-17-ONES, UPON TREATMENT WITH A MILD REDUCING AGENT YEILDS 14B-HYDROXY-15ANDROSTEN-17-ONES, USEFUL INTERMEDIATES IN THE SYNTHESIS OF STERODIAL CARDENOLIDES. PREFERRED SPECIES ARE 14 B-HYDROPEROXY-5A-15 ANDROSTEN3B-OL-17-ONE 3-ACETATE AND THE 5B-EPIMER THEREOF (PREPARED BY THE ACTION OF OXYGEN OR 5A-14-ANDROSTEN-3B-OL17-ONE 3-ACETATE AND THE 5B-EPIMER THEREOF, RESPECTIVELY) EACH OF WHICH, UPON MILD REDUCTION, PREFERABLY WITH TRIETHYL PHOSPHITE, YEILDS 14B-HYDROXY-5A-15-ANDROSTEN-3BOL-17-ONE 3-ACETATE AND THE 5B-EPIMER THEROF, RESPECTIVELY, WHICH ARE USEFUL INTERMEDIATES IN THE SYNTHESIS OF UZARIGENIN AND DIGITOXIGENIN, RESPECTIVELY.
专利号:US-2018150597-A1 优先权日:2016-11-29 标题 :Method for optimal design of polynucleotides sequences for analysis of specific events in any genetic region of interest 发明人:BERTHOUMIEUX SARA; FOURNE YANNICK; KOMATSU JUN; FER FREDERIC; BENSIMON AARON 权利人:GENOMIC VISION SA 摘要:Methods including in-silico steps for design and synthesis of Genomic Morse Code (“GMCâ€?) probes including design of combinations of polynucleotide sequences and labelling colors for analysis of large rearrangements in targeted genetic regions as well as allele characterization of complex regions and localization of events such as replication, DNA reparation or epigenetics in particular regions. Color-encoded sets of probes that produce characteristic or unique color patterns when painted on a target nucleic acid sequence. Methods for using color-encoded sets of probes.
专利号:US-2006257560-A1 优先权日:2004-12-30 标 题 :Polymer surfaces for insitu synthesis of polymer arrays 发明人:BARONE ANTHONY D; LI HANDONG; MCGALL GLENN H 权利人:AFFYMETRIX INC 摘要:In one aspect of the present invention polymers are used to create films providing three-dimensional array substrates. The films were stable and presented good hydroxyl group numbers as compared with arrays without polymer films. It is an object of the present invention that three dimensional arrays substrates provide a means to obtain higher density polymer arrays.
专利号:US-2022160788-A1 优先权日:2019-03-22 标题 :Bifunctional vectors allowing bcl11a silencing and expression of an anti-sickling hbb and uses thereof for gene therapy of b-hemoglobinopathies 发明人:MICCIO ANNARITA; AMENDOLA MARIO; BRUSSON MÉGANE; CAVAZZANA MARINA; MAVILIO FULVIO 权利人:INST NAT SANTE RECH MED; UNIV DEVRY VAL DESSONNE; ASSIST PUBLIQUE HOPITAUX PARIS APHP; UNIV PARIS; FOND IMAGINE 摘要:The #β-hemoglobinopathies #β-thalassemia (BT) and sickle cell disease (SCD) are the most frequent genetic disorders worldwide. These diseases are caused by mutations causing reduced or abnormal synthesis of the β-globin chain of the adult hemoglobin (Hb) tetramer. Here, the inventors intend to improve HSC-based gene therapy for β-thalassemia and SCD by developing an innovative, highly infectious LV vector expressing a potent anti-sickling β-globin transgene and a second biological function either increasing fetal γ-globin expression (for β-thalassemia and SCD). More particularly, the inventors have designed a novel lentivirus (LV), which carry two different functions: βAS3 gene addition and gene silencing. This last strategy allows the re-expression of the fetal γ-globin genes (HBG1 and HBG2) and production of the endogenous fetal hemoglobin (HbF). Elevated levels of HbF and HbAS3 (Hb tetramer containing βAS3-globin) will benefit the β-hemoglobinopathy phenotype by increasing the total amount of β-like globin that will: (i) reduce the alpha precipitates and improve the alpha/non alpha ratio in β-thalassemia, and (ii) reduce the sickling in SCD. This combined strategy will improve the β-hemoglobinopathy phenotype at a lower vector copy number (VCN) per cell compared to a LV expressing the βAS3 alone.
专利号:US-6833445-B2 优先权日:2000-01-21 标题:Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity 发明人:GOODMAN MURRAY; TOR YITZHAK; BAKER TRACY; LUEDTKE NATHAN 权利人:UNIV CALIFORNIA 摘要:Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.
1: Shao LR, Janicot R, Stafstrom CE. Na+-K+-ATPase functions in the developing hippocampus: regional differences in CA1 and CA3 neuronal excitability and role in epileptiform network bursting. J Neurophysiol. 2021 Jan 1;125(1):1-11. doi: 10.1152/jn.00453.2020. Epub 2020 Nov 18. 46(11-12):1131-1143. doi: 10.1007/s10886-020-01225-y. Epub 2020 Nov 12. 287:109267. doi: 10.1016/j.vetpar.2020.109267. Epub ahead of print. 9:1469. doi: 10.3389/fonc.2019.01469.
合成参考文献
参考文献:10.1007/s00395-011-0206-8 摘要:Tsai CF, Chen YC, Lin YK, Chen SA, Chen YJ. Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium. Basic Res Cardiol. 2011 Nov;106(6):979–93. doi: 10.1007/s00395-011-0206-8.