CAS: 64951-10-6; Imidazo[1,2-A]Pyrimidine-2-Carboxylic Acid

相似化合物

64951-06-0 143982-40-5 907945-69-1

上下游产品

CAS号109-12-6 2-氨基嘧啶 | CAS号1113-59-3 3-溴丙酮酸

📜1,3,5-三嗪-2,4,6-三胺,N,N'''-1,2-乙二基二[n-[3-[[4,6-二[丁基(2,2,6,6-四甲基-4-哌啶基)氨基]-1,3,5-三嗪-2-基]氨基]丙基]-N,N''-二丁基-N,N''-二(2,2,6,6-四甲基-4-哌啶基)-,3-溴丙酮酸置于对甲苯磺酸体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,125.0 °C,400.01 Kpa 条件下,反应 0.17H,以60%的收率获得产物咪唑[1,2-A]嘧啶-2-羧酸
参考文献:高功能化咪唑并[1,2-A]杂环的全自动连续流动合成
标题:高功能化咪唑并[1,2-A]杂环的全自动连续流动合成
摘要:第一个直接从 2-氨基吡啶和溴丙酮酸连续流动合成咪唑并[1,2-A]吡啶-2-羧酸的方法已经开发出来,这代表了相对于相应烧瓶内方法的显着进步.该工艺适用于咪唑并[1,2-A]吡啶-2-甲酰胺(包括mur连接酶抑制剂)的多步合成,使用两个微反应器,多步连续流动工艺,无需分离中间体.
DOI:10.1021/ol902433A

专利信息

专利号:US-8841306-B2
优先权日:2008-11-20
标 题:Antimicrobials
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; KANWAR SANDEEP; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; KANWAR SANDEEP; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella , acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.