5,7-二氯靛红 反应生成 2,4-二氯苯胺 参考文献:Danaila,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1909,Vol. 149,P. 1385 标题:Danaila,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1909,Vol. 149,P. 1385
专利号:US-11040938-B2 优先权日:2016-07-27 标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts 发明人:MA BING; PAN SHUAI 权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH 摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.
专利号:US-8735391-B2 优先权日:2008-09-26 标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods 发明人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J 权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS 摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
专利号:US-5243032-A 优先权日:1989-06-22 标题:Preparation of azo pigments with low pcb content by coupling in the presence of olefins 发明人:RIEPER WOLFGANG 权利人:HOECHST AG 摘要:The production which is customary in practice of monoazo compounds based on dichloro- and trichloroanilines or disazo compounds of the chlorinated biphenyl series by conventional coupling methods meets with difficulties in that the resulting pigments are contaminated by traces of polychlorinated biphenyls. n According to the invention, it has now been found that by addition of water-soluble olefins of the type ##STR1## (R =H, alk or Oalk; X =--COOR 1 , --CONHR 2 or --NR 3 COR 4 ) n in the azo coupling, the side reactions which form PCBs can be decidedly suppressed during synthesis of the pigments.
专利号:CN-114057659-B 优先权日:2021-11-02 标题:An intermediate for the synthesis of sulfentrazone and its synthesis method
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
参考标题:A New Synthesis Of Phthalimidines 作者:L. Yu. Ukhin,K. Yu. Suponitsky,L. V. Belousova,Zh. I. Orlova |发布日期:2009.12 摘要:A New Synthesis Of Phthalimidines Is Described. 3-Acyloxy-2-Aryl- And 2-Acylamino-3-Acyloxyphthalimidines Were Prepared By The Reaction Of 3-Arylaminophthalides Or O-Formylbenzoic Acid Acylhydrazones With Acetic Or Propionic Anhydrides. Their Reactions With O-, N-, S-, And C-Nucleophiles Were Studied. The Structure Of 2-Acetyl(Cyanoacetyl)Amino-3-Acetoxyindolin-1-One Was Confirmed By X-Ray Diffraction
合成参考文献
参考文献:10.2478/v10102-011-0015-9 摘要:Haluzová I, Modrá H, Blahová J, Havelková M, Siroká Z, Svobodová Z. Biochemical markers of contamination in fish toxicity tests. Interdiscip Toxicol. 2011 Jun;4(2):85–9. 参考文献:10.1107/s1600536811012463 摘要:Shakuntala K, Foro S, Gowda BT. 2,4-Dichloro-anilinium 4-chloro-benzene-sulfonate monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1077.