CAS: 3686-58-6; Methyl 2-(2-(Diethylamino)Acetamido)-3-Methylbenzoate

上下游产品

2-氨基-3-甲基苯甲酸甲酯 Methyl 2-Amino-3-Methylbenzoate 22223-49-0

📜Methyl 2-Formamido-3-Methylbenzoate置于三乙胺,三氯氧磷体系中,用 二氯甲烷,水 用作溶剂,化学反应 96.0H,反应生成托利卡因
参考文献:通过多组分反应进行局部麻醉
标题:通过多组分反应进行局部麻醉
摘要:全局思考,局部行动:目前的麻醉剂结构多样性有限,合成效率低下,毒性越来越大.因此,迫切需要具有改进的化学合成的新支架.在这里,我们报告了通过多组分反应化学在一步合成中获得商业和新型局部麻醉剂.我们评估了合成文库对小鼠海马脑切片自发活动的影响.
Doi:10.1002/cmdc.202200246

专利信息

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.