CAS: 3475-65-8; 2-(3-((4-Amino-2-Methylpyrimidin-5-yl)Methyl)-4-Methylthiazol-3-Ium-5-yl)Ethyl Trihydrogen Triphosphate
该化合物是硫胺磷酸酯(Vitamin B1)的磷酸化衍生物,其特征是它作为各种生化过程特别是碳水化合物代谢过程中的共聚物发挥作用.ThTP参与磷酸盐组的转移,这对细胞的能源生产至关重要.化合物通常是在水中溶解的白晶状固体,反映了由于多种磷酸化合物的存在而具有的极性.Thiamine 三磷酸盐在...
- 英文名称2-(3-((4-Amino-2-Methylpyrimidin-5-yl)Methyl)-4-Methylthiazol-3-Ium-5-yl)Ethyl Trihydrogen Triphosphate
- 中文名称[[2-[3-[(4-氨基-2-甲基嘧啶-5-基)甲基]-4-甲基-1,3-噻唑-3-鎓-5-基]乙氧基-羟基磷酰]氧基-羟基磷酰]磷酸氢酯
- IUPAC名称3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-((hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)oxy)ethyl)-4-methylthiazol-3-ium chloride
- 其它别名Thiamine(1+) Triphosphate(1-); Iwlrowzyzpnofc-Uhfffaoysa-N; Thiazolium, 3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-(4,6,8,8-Tetrahydroxy-4,6,8-Trioxido-3,5,7-Trioxa-4,6,8-Triphosphaoct-1-yl)-, Inner Salt; Thiamine Triphosphate Trioctylamine; Rasagiline Impurity 33-13C3; Tocopherol Impurity 15; Thiamine Impurity 38
- CAS编号3475-65-8
- MFCD编号:MFCD03427532
- FDA UNII编号:464M6AQ7IV
- 分子式:C12H20ClN4O10P3S分子量:540.75
- 产品CID: 1351778
- 产品分类有机原料 → 有机杂环化合物 → 二嗪类
合成工艺路线路线简述
📜Thiamin 反应生成 [[2-[3-[(4-氨基-2-甲基嘧啶-5-基)甲基]-4-甲基-1,3-噻唑-3-鎓-5-基]乙氧基-羟基磷酰]氧基-羟基磷酰]磷酸氢酯
参考文献:Wojtarowicz,Tadeusz;Zborucki,Zygmunt;Piorkowski,Lucjan
标题:Wojtarowicz,Tadeusz;Zborucki,Zygmunt;Piorkowski,Lucjan
专利信息
专利号:US-10696992-B2
优先权日:2015-12-18
标 题:Genetically modified bacterial cell factory for thiamine production
发明人：GRONENBERG LUISA; SALOMONSEN BO; FERLA MATTEO; GENEE HANS JASPER
权利人:BIOSYNTIA APS; BIOSYNTHIA APS
摘要:The invention provides a genetically modified bacterium for production of thiamine; where the bacterium is characterized by a transgene encoding a thiamine monophosphate phosphatase (TMP phosphatase having EC 3.1.3.-) as well as transgenes encoding polypeptides that catalyze steps in the thiamine pathway. The genetically modified bacterium is characterized by enhanced synthesis and release of thiamine into the extracellular environment. The invention further provides a method for producing thiamine using the genetically modified bacterium of the invention; as well as the use of the genetically modified bacterium for extracellular thiamine production.
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📌 第三方产品分析报告
合成参考文献
摘要:Totskiĭ VN, Khalmuradov AG. [Biochemical aspects of thiamine transport]. Ukr Biokhim Zh (1978). 1980 Jan;52(1):110–22.
摘要:Ianchiĭ OR, Parkhomenko IuM, Donchenko GV. [Intracellular localization of thiamine-binding proteins in the liver and kidneys of rats]. Ukr Biokhim Zh (1999). 2003 Nov;75(6):111–4.
摘要:Koyama S, Kawasaki T. [Biosynthesis and possible physiological roles of thiamine triphosphate in animal]. Seikagaku. 1992 Jun;64(6):393–7.
摘要:Voskoboev AI, Chernikevich IP. [Biosynthesis of thiamine triphosphate and identification of thiamine diphosphate-binding proteins in the rat liver hyaloplasm]. Biokhimiia. 1985 Sep;50(9):1421–7.
参考文献:10.1016/0076-6879(86)22143-6
摘要:Cooper JR, Nishino K. Enzymatic synthesis of thiamin triphosphate. Methods Enzymol. 1986;122():24–9. doi: 10.1016/0076-6879(86)22143-6.
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