CAS: 3261-05-0; 5-Chlorobenzofuran-3-One

该化合物是一种氯化的苯并呋喃衍生物,在有机合成和制药中间应用方面有显著的用途,其结构以活性3-1细胞和氯替代成分为主,能够有选择地发挥作用,对建设复杂的环环绕框架很有价值;化合物在标准条件下具有稳定性,便于处理和储存;其电子退出氯组增强了核生殖替代和交叉反应的再活动性,为医药化学和材料科学研究提供了多种用途;可提供高纯度,以确保合成途径的再生性;对于受控制的环境来说,它可充当开发生物活性分子和特殊化学品的先质.

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3260-94-4 3260-78-4 5590-44-3

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上下游产品

2-carboxymethoxy-5-chloro-benzoic acid 2-chloro-1-(5-chloro-2-hydroxy-phenyl)-ethanone diazomethane N-methyl-N-nitrosotoluene-p-sulfonamide 5-chloro-2-morpholin-4-ylmethyl-benzofuran-3-ol 8-chloro-10H-benzofuro[3,2-b]indole 5-chloro-2,3-dihydro-benzofuran-3-ylamine 2-chloro-N-(5-chloro-2,3-dihydro-3-benzofuryl)acetamide

合成工艺路线路线简述

    📜5-氯代水杨酸置于硫酸,Potassium Tert-Butylate,Potassium Carbonate体系中,用 四氢呋喃,丙酮 作为反应溶剂,化学反应 122.0H,反应生成 5-氯-3-苯并呋喃酮
    参考文献: Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators[fr] Nouveaux Hétéroaryl-Imidazoles Et Hétéroaryl-Triazoles à Titre De Modulateurs De Gamma-Sécrétase
    标题: Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators[fr] Nouveaux Hétéroaryl-Imidazoles Et Hétéroaryl-Triazoles à Titre De Modulateurs De Gamma-Sécrétase
    摘要:所述化合物及其药学上可接受的盐被披露,其中所述化合物具有如下式的结构;(i)如规范中定义的那样.相应的药物组合物,治疗方法,合成方法和中间体也被披露.

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    专利信息


    专利号:US-2012053165-A1
    优先权日:2009-03-03
    标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
    发明人：ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
    权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-2012202787-A1
    优先权日:2009-10-20
    标 题:Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
    发明人：AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN
    权利人:AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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    合成参考文献

    参考DOI号:10.1021/acs.orglett.0c01096
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