多巴胺 反应生成5,6-二羟基吲哚啉 参考文献:Enhanced Study And Control Of Analyte Oxidation In Electrospray Using A Thin-Channel,Planar Electrode Emitter 标题:Enhanced Study And Control Of Analyte Oxidation In Electrospray Using A Thin-Channel,Planar Electrode Emitter 摘要:介绍了一种薄通道平面电极发射器装置,用于研究和控制电喷雾离子源中发射器电极上分析物的电化学氧化.对于不是特别容易氧化的分析物,平面电极装置的分析功能与使用更常见的不锈钢管电极的发射器系统类似.对于较易氧化的分析物,该装置可通过简单快速地改变电极材料,电极面积,电极覆盖层,电极上方的通道高度或溶液流速,实现接近 100% 的氧化效率或完全消除分析物氧化.与使用管状电极相比,平面电极发射器系统在改变电极面积和材料性质以及改变分析物向电极表面的质量传输方面具有更大的灵活性.这些参数中的每一个都对电化学反应的控制至关重要,使用这种发射器电极配置可以很容易地对其进行研究或利用. Doi:10.1021/ac020267B
专利号:US-5536843-A 优先权日:1992-02-12 标题 :Synthesis of indoles by dehydrogenation of indolines 发明人:KNUEBEL GEORG; MICHEL ROSWITHA; ROSE DAVID 权利人:HENKEL KGAA 摘要:##STR1## By dehydrating indolines or their salts, the corresponding indoles having formula (I) are obtained. In the formula, R 1 and R 3 represent independently from each other hydrogen or alkyl groups with 1 to 4 C atoms, R 2 stands for hydrogen, a methyl or a carboxyl group, R 4 and R 5 represent independently from each other hydrogen, amino groups, hydroxy groups, alkyl groups with 1 to 4 C atoms or alkoxy groups with 1 to 4 C atoms, or, in case R 4 and R 5 are bound to adjacent C atoms, both residues may also represent together an alkylene dioxy group with 1 to 4 C atoms. This process allows high yields of very pure indoles to be produced.
专利号:WO-2025140300-A1 优先权日:2023-12-26 标 题:Synthesis method for 5,6-dihydroxyindole and intermediate thereof 发明人:CHEN CONGXI; TIAN YONGJIAN; CAI TIAN; QIAO YUEFANG 权利人:INNOCHEM BEIJING TECH CO LTD 摘要:Provided in the present invention are a synthesis method for 5,6-dihydroxyindole and an intermediate thereof. The method comprises: by using a hydrohalide salt or other acid salts (IC241-01) of 5,6-dihydroxyindoline as raw materials, sequentially protecting the heteroatom nitrogen and phenolic hydroxyl, so as to obtain an intermediate compound 1-benzyloxycarbonyl-5,6-dibenzyloxyindoline (IC241-03); then performing an oxidation reaction to obtain an intermediate compound 1-benzyloxycarbonyl-5,6-dibenzyloxyindole (IC241-04); and in the presence of trace amounts of an antioxidant and a polymerization inhibitor, performing catalytic hydrogenation to remove the protecting group, so as to obtain 5,6-dihydroxyindole (DHI). The method in the present invention involves reactions with mild conditions, can stably realize mass production, uses feasible raw materials, and achieves controllable cost and good process reproducibility. In addition, on the basis of the synthesis strategy of removing the protecting group in the final step, and because of the functions of the trace amounts of the antioxidant and the polymerization inhibitor, the target product 5,6-dihydroxyindole (DHI) has the comprehensive advantages of light color, high purity, convenient storage and subsequent use, etc.
专利号:WO-2006053688-A1 优先权日:2004-11-17 标 题:Cosmetic and dermatological preparations for the treatment of mature skin 发明人:DOERING THOMAS 权利人:HENKEL KGAA; DOERING THOMAS 摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.
专利号:WO-9316046-A1 优先权日:1992-02-12 标 题:Synthesis of indoles by dehydration of indolines
专利号:WO-2008028776-A1 优先权日:2006-09-06 标题 :Agents containing bioquinones and specific emulsifiers 发明人:SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE 权利人:HENKEL KGAA; SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE 摘要:The invention relates to cosmetic agents, in particular hair treatment agents, containing at least one specific emulsifier and at least one bioquinone. Treating the hair with said agents activates the keratin synthesis of hair keratin that declines with age.
专利号:EP-0625968-B1 优先权日:1992-02-12 标 题:Synthesis of indoles by dehydration of indolines
参考文献:10.1016/s0031-9422(00)00383-6 摘要:Kobayashi N, Schmidt J, Wray V, Schliemann W. Formation and occurrence of dopamine-derived betacyanins. Phytochemistry. 2001 Mar;56(5):429–36. doi: 10.1016/s0031-9422(00)00383-6.