CAS: 24932-48-7; 1,2-Dibromo-4,5-Dimethylbenzene

该化合物是一种溴化芳香化合物,其分子式为C8H8Br2;它是一个有机合成的多用途中间体,特别是在制备药品,农用化学品和特殊化学品方面;其稳定的结构和反应性使其适合交叉反应和进一步的功能化;该化合物由于其溴含量,通常在受控制的条件下处理.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号95-47-6 邻二甲苯 | CAS号22364-29-0 2-溴-4,5-二甲基苯胺 | CAS号22364-28-9 2Bromo-45dimeth... | CAS号2198-54-1 3',4'-二甲基乙酰苯胺 | CAS号583-71-1 3,4-二甲基溴苯 | CAS号7726-95-6 溴素 | CAS号7553-56-2 碘 | CAS号95-47-6 邻二甲苯 | CAS号95-63-6 1,2,4-三甲苯 | CAS号95-93-2 1,2,4,5-四甲苯 | CAS号24006-87-9 1,2-Benzenediac... | CAS号101300-66-7 (4,5-dimethyl-2... | CAS号13209-20-6 Α,Α,Α',Α',4,5-六溴邻二甲苯 | CAS号139914-16-2 6,7-二溴-2-萘腈 | CAS号16932-45-9 2,6-二甲氧基溴苯 | CAS号1267964-42-0 2-bromo-2',6'-d... | CAS号24063-28-3 4,5-二溴邻苯二甲酸

合成工艺路线路线简述

    邻二甲苯置于溴,碘体系中,用53%的收率获得1,2-二溴-4,5-二甲苯
    参考文献:噻吩稠合螺旋烯的合成
    标题:噻吩稠合螺旋烯的合成
    摘要:具有末端噻吩环的五螺烯和六螺烯的合成是通过使用 Fürstner 方法对邻,邻'-炔基取代的三芳基进行异构化来实现的.使用 Johnphos 络合金 (I) 作为催化剂获得了最佳结果.
    Doi:10.1002/ejoc.202300545

    海关参考信息

    专利信息


    专利号:US-9707553-B2
    优先权日:2011-07-11
    标题 :P-chirogenic organophosphorus compounds
    发明人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; LAUREANO HUGO; HENRY JEAN-CHRISTOPHE; LEROUX FREDERIC; COLOBERT FRANCOISE
    权利人:CENTRE NAT DE LA RECH SCIENT (CNRS); UNIV BOURGOGNE; UNIV STRASBOURG; SYNTHELOR SAS
    摘要:P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). n n n n n n n n n n Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

    专利号:WO-2023086799-A1
    优先权日:2021-11-09
    标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
    发明人:HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
    权利人:VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

    专利号:US-10249833-B2
    优先权日:2016-03-02
    标 题:Phthalocyanine compound and synthesis method and use thereof
    发明人:GAO XUE; LIU FEI; ZHANG CAN
    权利人:BOE TECHNOLOGY GROUP CO LTD
    摘要:The invention relates to a phthalocyanine compound, which has a structure as represented by Formula I, wherein A represents a transition metal or a rare earth metal; R1 represents a phenyl group, a naphthyl group, or a C 4 -C 16 n-alkyl group. The aromatic phthalocyanine compound having the structure of Formula I provided in the invention contains a transition metal or a rare earth metal, and introduces a peripheral substituent into a linearly extended Ï€-conjugated system. It is relatively stabler at 400° C. or less and will be easily evaporated in vacuum to form a uniform thin film, and has good thermal stability, high chemical stability, and high mobility. The organic semiconductor device has the features of relatively fast on-off speed, relatively high on-off ratio, and strong reliability.

    专利号:CN-105541850-A
    优先权日:2016-03-02
    标题:A kind of phthalocyanine compound and its synthesis method and application

    专利号:CN-105541850-B
    优先权日:2016-03-02
    标题:A kind of phthalocyanine compound and its synthesis method and application

    专利号:CN-110452178-B
    优先权日:2018-05-07
    标 题 :A kind of chiral carbene precursor compound with sandwich structure and its synthesis method
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Synthesis Of Fluorene And Indenofluorene Compounds: Tandem Palladium-Catalyzed Suzuki Cross-Coupling And Cyclization
    作者:Tao-Ping Liu,Chun-Hui Xing,Qiao-Sheng Hu |发布日期:2010.4.6
    摘要:"Fluor" It: Palladium‐catalyzed Tandem Reactions, In Which C(Sp3)h Bond Activation Is The Key Step (See Scheme; Dma=dimethylacetamide), Lead To Substituted Fluorenes And Indenofluorenes Through Annulation In High Yield And In One Step. This Method Has Potential For The Preparation Of Other Cyclic Compounds, As Well As Substituted Oligofluorenes And Polyfluorenes.

    合成参考文献


    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 116.
    摘要:Didier, D.; Trauner, F.; Jiang, D., Science of Synthesis: Knowledge Updates, (2024) 1, 262.
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