专利号:US-11365211-B2 优先权日:2018-02-01 标 题 :Stereoselective synthesis and process for the manufacturing of 2′-deoxynucleosides 发明人:ZHANG LIANHAO; VISHNUVAJJALA BABURAO; MORRIS JOEL; BAHDE ROBERT; DENYSENKO SERGIY M; LOPEZ OMAR DIEGO; WISHKA DONN GREGORY 权利人:THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES; ALCHEM LABORATORIES CORP; US HEALTH 摘要:Methods for stereoselective synthesis and manufacturing of 2′-deoxynucleosides, such as 2′-ribonucleosides, are disclosed. In some embodiments, the 2′-deoxynucleoside is a β-anomer of a 2′-deoxynucleoside having a 3′ α hydroxyl, 4′ β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4′-thio-2′-deoxycytidine (T-dCyd) and 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).
专利号:US-7153921-B2 优先权日:2004-02-03 标 题 :Synthesis of elastomeric carborane-siloxanes by hydrosilation reactions 发明人:KELLER TEDDY M; KOLEL-VEETIL MANOJ K 权利人:US NAVY 摘要:A crosslinked polymer and process of making it are disclosed. A copolymer having at least one alkyne group, carborane group, and alkylsiloxane group is reacted with a siloxane crosslinker in a hydrosilation reaction. This produces a crosslinked polymer where the crosslink sites are reacted alkyne groups.
专利号:US-5059705-A 优先权日:1990-02-28 标 题 :Butadienyl group-containing siloxane compounds and method of producing the same 发明人:OKINOSHIMA HIROSHIGE; KANBARA HIROSHI 权利人:SHINETSU CHEMICAL CO 摘要:Siloxane compounds having the following formula [1]: ##STR1## wherein each R is a substituted or unsubstituted monovalent hydrocarbon group having from 1 to 10 carbon atoms, and n is an integer of from 0 to 100. The compounds are extremely high in reactivity and, therefore, useful as an intermediate or modifying agent in the synthesis of silicone resins and other various organic resins.
专利号:US-5756629-A 优先权日:1996-11-27 标题:Method for synthesis of linear inorganic-organic hybrid polymers 发明人:KELLER TEDDY M; SUNDAR RAJ A 权利人:US ARMY 摘要:A method of preparing a linear inorganic-organic hybrid polymer includes the steps of cooling a reaction medium to a first starting temperature below the ambient temperature and not less than about -10° C., adding n-butyllithium and an organic compound capable of reacting with n-butyllithium to form an organo-dilithium compound to the reaction medium, allowing the organic compound and the n-butyllithium to react to form an organo-dilithium compound while allowing the reaction medium to warm, cooling the reaction medium to a second starting temperature below the ambient temperature and not less than about -10° C., adding an inorganic compound containing at least two halogen atoms and capable of reacting with said organo-dilithium compound to form a linear inorganic-organic hybrid polymer to the reaction medium, and allowing the inorganic compound to react with the organo-dilithium compound to form a linear inorganic-organic hybrid polymer while allowing the reaction medium to warm to the ambient temperature. The cooling to the first and second starting temperatures may be accomplished by any method known in the art for cooling a reaction medium, for example by cooling with an ice water or salt/ice water bath or by cooling with an automated cooling or refrigerating system.
专利号:US-2005171317-A1 优先权日:2004-02-03 标 题 :Synthesis of elastomeric carborane-siloxanes by hydrosilation reactions
专利号:US-7649070-B2 优先权日:2003-02-28 标 题:Synthesis of elastomeric poly(carborane-siloxane-acetelyene)s