CAS: 20847-05-6; 6-Azido-6-Deoxy-D-Galactose

该化合物是葡萄糖的一种衍生物,第六类碳的氢氧基基体组被一个Azido组(N3)取代.这种改变使分子具有独特的化学特性,使其成为各种生化应用中的宝贵化合物,特别是在球菌学和药用化学领域.Azido组因其能够参与点击化学反应,允许其他分子的聚合,这在药物开发和生物融合技术中非常有用.该化合物通常是白色对非白色固体的,在极地溶剂中溶解.其再活性受Azido组的存在影响,该组可以减少成一个矿,或参与循环反应.作为6-脱氧糖,它缺乏第六位的氢氧基基组,它与普通葡萄糖相比,改变了生物相互作用.由于Azido组的潜在再活动,应当观察安全和处理预防措施.

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CAS号65371-16-6 6-叠氮基-6-脱氧-1,2-... | CAS号23701-87-3 Methyl 6-azido-... | CAS号97-30-3 甲基葡萄糖苷 | CAS号6619-09-6 甲基-6-O-对甲苯磺酰基-Α... | CAS号57-50-1 蔗糖 | CAS号2280-44-6 D-glucopyranose | CAS号18549-40-1 单丙酮葡萄糖 | CAS号65371-17-7 6-Azido-6-desox... | CAS号65371-16-6 6-叠氮基-6-脱氧-1,2-... | CAS号4460-60-0 6-氨基-6-脱氧-D-吡喃葡...

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    专利号:US-5576426-A
    优先权日:1988-08-30
    标 题:Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose
    发明人:WONG CHI-HUEY; DURRWACHTER JOHN R; PEDERSON RICHARD L
    权利人:SEARLE & CO
    摘要:The present invention relates to aldolase catalyzed stereo-selective synthesis of sugars and compositions of matter comprising arabinohexulose, xyloheptulose, threohexulose, and xylohexulose.

    专利号:US-2023212216-A1
    优先权日:2019-12-20
    标 题:Synthesis of lactone derivatives and their use in the modification of proteins
    发明人:MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
    权利人:GENIE BIOTECH UK LTD
    摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

    专利号:AU-2020409711-A1
    优先权日:2019-12-20
    标题 :Synthesis of lactone derivatives and their use in the modification of proteins

    专利号:EP-4076533-A1
    优先权日:2019-12-20
    标 题:Synthesis of lactone derivatives and their use in the modification of proteins

    专利号:US-5143831-A
    优先权日:1988-08-30
    标 题:Fructose 1,6-diphosphate aldolase catalyzed steroselective synthesis of sugars

    专利号:CA-3164962-A1
    优先权日:2019-12-20
    标题 :Synthesis of lactone derivatives and their use in the modification of proteins

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    合成参考文献


    参考文献:10.1007/978-981-97-4864-8_1
    摘要:Hao Y, Liu D, Deng Q, Dong S. Chemical Tools for Decoding the Functions of O-GlcNAcylation. 2024. In: Chemistry and Biology of O-GlcNAcylation.
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