CAS: 17754-44-8; Potassium (2R,3R,4R,5R,6R)-6-(((2R,4R,4Ar,6Ar,7S,9R,11As,11Br)-4-Carboxy-7-Hydroxy-11B-Methyl-8-Methylenetetradecahydro-6A,9-Methanocyclohepta[a]Naphthalen-2-yl)Oxy)-2-(Hydroxymethyl)-5-((3-Methylbutanoyl)Oxy)Tetrahydro-2H-Pyran-3,4-Diyl Bis(Sulfate)
该化合物是自然形成的胶片,产自Astracesae家族的植物Atratylis compmefera, 以其强大的生物活动而闻名,特别是其抑制了在mitochondria 的核酸转移器,它扰乱了ATP的运输,可能导致细胞能量耗竭.该化合物的特点在于它能够在某些细胞类型中诱发吸附性病,并研究其潜在的治疗用途及其毒性影响. 蒸馏石路通常以白色到白色以外的晶体粉末的形式出现,在极地溶剂中溶解. 它的化学结构具有糖味,它与agarlycone相连, 有助于其生物活动.由于毒性,它必须处理在实验室环境中的微粒路边,而且其使用通常限于研究目的. 总的来说, 蒸馏石路是药物学研究中的重要化合物,特别是在二甲状腺功能和细胞代谢中.
- 英文名称Potassium (2R,3R,4R,5R,6R)-6-(((2R,4R,4Ar,6Ar,7S,9R,11As,11Br)-4-Carboxy-7-Hydroxy-11B-Methyl-8-Methylenetetradecahydro-6A,9-Methanocyclohepta[a]Naphthalen-2-yl)Oxy)-2-(Hydroxymethyl)-5-((3-Methylbutanoyl)Oxy)Tetrahydro-2H-Pyran-3,4-Diyl Bis(Sulfate)
- 中文名称钾(2R,3R,4R,5R,6R)-6-(((2R,4R,4AR,6AR,7S,9R,11AS,11BR)-4-羧基-7-羟基-11B-甲基-8-亚甲基四十氢化-6A,9-亚甲基环庚[A]萘-2-基)氧基)-2-(羟甲基)-5-((3-甲基丁酰基)氧基)四氢-2H-吡喃-3,4-二基双(硫酸盐)
- IUPAC名称potassium (2R,3R,4R,5R,6R)-6-(((2R,4R,4aR,6aR,7S,9R,11aS,11bR)-4-carboxy-7-hydroxy-11b-methyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalen-2-yl)oxy)-2-(hydroxymethyl)-5-((3-methylbutanoyl)oxy)tetrahydro-2H-pyran-3,4-diyl bis(sulfate)
- 其它别名Atractyloside Sodium Salt(Rg); Dipotassium Hydrogen 15Alpha-Hydroxy-2Beta-[[2-O-Isovaleryl-3,4Alpha-Di-O-Sulphonato-Beta-D-Glucopyranosyl]Oxy]-19-Norkaur-16-En-18-Oate; (4α,15S)-15-Hydroxy-2β-[[2-O-(3-Methyl-1-Oxobutyl)-3-O,4-O-Bis(Potassiosulfo)-β-D-Glucopyranosyl]Oxy]-19-Norkaur-16-En-18-Oic Acid
- CAS编号17754-44-8
- MFCD编号:MFCD00221736
- EINECS号:241-744-8
- FDA UNII编号:H6WC6L09RM
- 分子式:C30H44K2O16S2分子量:803.0
- 产品CID: 903984
- 同类组份化合物CAS17754-44-8 (free acid)102130-43-8 (potassium)
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合成参考文献
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参考文献:10.1080/15216549600201152
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参考文献:10.1016/s0278-6915(01)00044-8
摘要:Obatomi DK, Blackburn RO, Bach PH. Effects of the calcium channel blocker verapamil and sulphydryl reducing agent dithiothreitol on atractyloside toxicity in precision-cut rat renal cortical and liver slices. Food Chem Toxicol. 2001 Oct;39(10):1013–21. doi: 10.1016/s0278-6915(01)00044-8.
参考文献:10.1016/j.cbpb.2006.04.002
摘要:García N, Martínez-Abundis E, Pavón N, Chávez E. Sodium inhibits permeability transition by decreasing potassium matrix content in rat kidney mitochondria. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2006 Aug;144(4):442–50. doi: 10.1016/j.cbpb.2006.04.002.
参考文献:10.1016/j.bbabio.2006.04.024
摘要:Khailova LS, Prikhodko EA, Dedukhova VI, Mokhova EN, Popov VN, Skulachev VP. Participation of ATP/ADP antiporter in oleate- and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2006 Sep;1757(9-10):1324–9. doi: 10.1016/j.bbabio.2006.04.024.
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