CAS: 168701-80-2; 8-Nitroguanine

上下游产品

2-amino-1,9-dihydro-6H-purin-6-one 2'-Deoxyguanosine G 8-bromoguanosine 8-aminoguanine 8-nitroxanthine

📜鸟嘌呤置于盐酸,过氧亚硝酸,Ammonium Formate体系中,化学反应 0.03H,反应生成8-硝基鸟嘌呤
参考文献:8-硝基黄嘌呤,一种衍生自2'-脱氧鸟苷或与硝酰氯进行dna反应的加合物.
标题:8-硝基黄嘌呤,一种衍生自2'-脱氧鸟苷或与硝酰氯进行dna反应的加合物.
摘要:活化的吞噬细胞会产生活性氮,包括硝酰氯和过氧亚硝酸盐,用于宿主防御入侵的病原体.已经提出,这些反应性氮物质可能引起dna损伤,因此有助于与慢性感染和炎症相关的多阶段致癌过程.以前的研究表明,过氧亚硝酸盐与鸟嘌呤,2'-脱氧鸟苷或dna形成8-硝基鸟嘌呤反应.我们在此报道了在2'-脱氧鸟苷或小牛胸腺dna与通过将亚硝酸盐与次氯酸混合而产生的亚硝酰氯的反应中,作为主要硝化产物的8-硝基黄嘌呤的形成,而8-硝基鸟嘌呤是这些反应中的次要产物.8-硝基黄嘌呤的特征在于其NMR和激光解吸电离质谱图以及8-硝基鸟嘌呤的脱氨基作用.还通过黄嘌呤与各种活性氮物质(包括亚硝酰氯,过氧亚硝酸盐,四氟硼酸硝鎓和加热的硝酸和亚硝酸)反应检测到8-硝基黄嘌呤的形成.通过与合成的8-硝基黄嘌呤共注射并将其还原为8-氨基黄嘌呤,证实了在硝基氯处理的dg和dna中8-硝基黄嘌呤的身份.这些反应中8-硝基黄嘌呤和8-硝基鸟嘌
Doi:10.1021/tx0002334

专利信息

专利号:US-2005004225-A1
优先权日:2003-04-16
标题:Oxidoreductase inhibitors and methods of screening and using thereof
发明人：BALENDIRAN GANESARATNAM K
摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.

专利号:US-6797822-B1
优先权日:2000-05-09
标题:Compositions and methods of use of 8-nitroguanine
发明人：HOLWITT ERIC A
权利人:CONCEPTUAL MINDWORKS INC
摘要:Novel methods for the synthesis of 8-nitroguanine are provided. Compositions comprising 8-nitroguanine, made by the novel synthetic methods are also provided herein. Methods of use of 8-nitroguanine, made by the novel synthetic methods, as a standard for detection of 8-nitroguanine in samples are also encompassed within the scope of the present invention. The present invention further concerns methods of predicting organ transplant rejection and detecting exposure to environmental stressors, such as ionizing radiation, toxic chemicals or infectious agents, by detecting 8-nitroguanine in one or more samples from a transplant recipient or an organism exposed to stress.

专利号:US-11920174-B2
优先权日:2016-03-03
标 题 :RNA analysis by total hydrolysis and quantification of released nucleosides
发明人：EBER FABIAN JOHANNES; WOCHNER ANIELA; ROOS TILMANN
权利人:CureVac SE
摘要:The present invention relates to analysis of an RNA molecule. It further relates to the use of this method for the quality control of an RNA molecule produced by in vitro transcription or for the quality control of an RNA molecule produced by chemical synthesis.