氯甲酸苄酯置于sodium Hydride,N,N-二异丙基乙胺体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 2.25H,反应生成N,N'-双(苄氧羰基)-1H-吡唑-1-甲脒
参考文献:An Efficient Method For The Preparation Of W,W'-Bis-Urethane Protected Arginine Derivatives
标题:An Efficient Method For The Preparation Of W,W'-Bis-Urethane Protected Arginine Derivatives
摘要:Fmoc-Arg(Omega,Omega)(Boc)2-Oh And Boc-Arg(Omega,Omega)(Cbz)2-Oh Were Prepared In Two Steps: Guanylation Of Cu(II)-Ornithine Complex At N(Delta) With N,N'-Bis-Urethane Protected Derivatives Of 1-Guanylpyrazole,Followed By N(Alpha)-Protection Using Either 9-Fluorenylmethyl Succinimidylcarbonate Or Di-T-Butyldicarbonate In The Presence Of Edta. The Overall Yields Of These Products (2 Steps) Were 65% And 73%.
Doi:10.1080/00397919308011149