CAS: 14437-41-3; [2-[(4-Chlorophenyl)Carbamoyl]-4,6-Diiodophenyl] Acetate

上下游产品

N-[4-氯苯基]-2-羟基-3,5-二碘苯甲酰胺 N-(4-Chlorophenyl)-2-Hydroxy-3,5-Diiodobenzamide 14437-46-8

📜N-[4-氯苯基]-2-羟基-3,5-二碘苯甲酰胺,乙酸酐置于磷酸体系中,化学反应 1.0H,反应生成氯碘沙尼
参考文献:水杨酰苯胺的设计,合成和多变量定量结构-活性关系-耶尔森菌中iii型分泌的强效抑制剂.
标题:水杨酰苯胺的设计,合成和多变量定量结构-活性关系-耶尔森菌中iii型分泌的强效抑制剂.
摘要:选择,合成和在三个循环中生物学评估水杨酰苯胺n-(4-氯苯基)-2-乙酰氧基-3,5-二碘联苯甲酰胺1A的类似物,后者是耶尔森氏菌iii型分泌(t3S)的抑制剂.首先,合成一组在水杨酸环部分具有变化的类似物以探测可能的结构变化.建立了基本的结构-活性关系,然后将其用于从水杨酰苯胺的主成分分析得分图中挑选出化合物,以生成第二组.使用d-最佳洋葱设计设计了第三组具有增加的生物活性的生物活性.使用与t3S抑制百分比相关的构件的pls评分矢量,计算了使用层次化部分最小二乘回归到潜在结构(hi-Pls)的定量构效关系模型.使用与hi-Pls模型相同的描述符集导出pls判别分析(pls-Da)模型.两种模型均通过外部测试仪进行了验证.
Doi:10.1021/jm070741B

专利信息

专利号:SU-790620-A1
优先权日:1979-06-01
标 题:2,4'-dichloro-5-aminobenzophenone as starting product for synthesis of drugs with antihelminthic action

专利号:US-4337274-A
优先权日:1978-05-30
标 题 :Flukicidal compounds
发明人：GORVIN JOHN H
权利人:BURROUGHS WELLCOME CO
摘要:Diphenylethers of the formula: ##STR1## their synthesis, formulations containing them, methods of making such formulations, and their use in the treatment of liver fluke infections in mammals.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.