CAS: 142340-99-6; ((((2-(6-Amino-9H-Purin-9-yl)Ethoxy)Methyl)Phosphoryl)Bis(Oxy))Bis(Methylene) Bis(2,2-Dimethylpropanoate)

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CAS号18997-19-8 特戊酸氯甲酯 | CAS号106941-25-7 阿德福韦 | CAS号116384-53-3 [[2-(6-氨基-9H-嘌呤... | CAS号53064-79-2 特戊酸碘甲酯 | CAS号66224-66-6 6H-Purin-6-imin... | CAS号707-99-3 9-(2-羟乙基)腺嘌呤

N4-Dimethylaminomethyledino-9-(2-Phosphonomethoxyethyl)Adenine Di(Pivaloyloxymethyl) Ester置于水,溶剂黄146,三乙胺体系中,用 水,乙酸乙酯 用作溶剂,化学反应 3.0H,反应生成阿德福韦酯
参考文献:Novel Process For Acyclic Phosphonate Nucleotide Analogs
标题:Novel Process For Acyclic Phosphonate Nucleotide Analogs
摘要:本发明提供了一种新颖的过程,用于制备无环膦酸酯核苷类似物,使用新颖的中间体.例如,(R)-9-(2-磷酸甲氧基丙基)腺嘌呤与二甲基甲酰胺二甲基缩醛反应,得到n4-二甲氨基甲基二氧杂-9-(2-磷酸甲氧基乙基)腺嘌呤,然后在三乙胺存在下与氯甲基-2-丙基碳酸酯反应,得到(R)-N4-二甲氨基甲基二氧杂-9-(2-磷酸甲氧基丙基)腺嘌呤二异丙醇,随后用乙酸去保护得到替诺福韦二异丙醇.替诺福韦二异丙醇然后与富马酸处理,得到替诺福韦二异丙醇富马酸盐.

专利信息

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-8278483-B2
优先权日:2006-02-07
标题:Process for synthesis of glycomimicking cationic amphiphiles
发明人：MAHIDHAR YENUGONDA VENKATA; CHAUDHURI ARABINDA; MUKHERJEE RAMA
权利人:MAHIDHAR YENUGONDA VENKATA; CHAUDHURI ARABINDA; MUKHERJEE RAMA; COUNCIL SCIENT IND RES
摘要:The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.

专利号:US-10995093-B2
优先权日:2016-04-07
标 题 :Synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′methylene-carbocyclic guanosine (FMCG)
发明人：CHU CHUNG K; MULAMOOTTTIL VARUGHESE ALEXANDER; MISHRA RAM C; SINGH UMA SHARAN
权利人:UNIV GEORGIA
摘要:The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R, 4R)-3-tert-butoxy-4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.

专利号:WO-2023118363-A1
优先权日:2021-12-22
标题:Method for the synthesis of a carbonyl-functionalised adduct
发明人：GODEHARD SIMON P; PELZER ALEXANDER
权利人:BRAIN Biotech AG
摘要:The invention relates to a method for the synthesis of a carbonyl-functionalised adduct.

专利号:US-9334273-B1
优先权日:2014-03-05
标题:Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
发明人：CHU DAVID C K; SINGH UMA S
权利人:UNIV GEORGIA
摘要:The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) from a readily available starting material (Vince lactam) in fourteen steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, D -2′-fluoro-6′-methylene cyclopentanol by diazotization, elimination, stereoselective epoxidation, fluorination and oxidative reduction of the Vince lactam in twelve steps is also provided.

专利号:US-7582758-B2
优先权日:2004-06-08
标 题:Lewis acid mediated synthesis of cyclic esters
发明人：MARTIN KEVIN V
权利人:METABASIS THERAPEUTICS INC
摘要:Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.