CAS: 141699-55-0; Tert-Butyl 3-Hydroxyazetidine-1-Carboxylate

相似化合物

18621-18-6 429669-07-8 54881-13-9

上下游产品

CAS号18621-17-5 N-二苯甲基氮杂环丁烷-3-醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号18621-18-6 3-羟基氮杂环丁烷盐酸盐 | CAS号45347-82-8 3-氮杂环丁醇 | CAS号1538-75-6 特戊酸酐 | CAS号54881-13-9 1-苄基氮杂环丁烷-3-醇 | CAS号123-91-1 1,4-二氧六环 | CAS号106-89-8 环氧氯丙烷 | CAS号90604-02-7 1-二苯甲基-3-羟基氮杂环丁烷盐酸盐 | CAS号147621-21-4 N-B°C-氮杂环丁烷 | CAS号429669-07-8 1-B°C-3-甲氧基基氮杂环丁烷 | CAS号398489-26-4 1-B°C-3-氮杂环丁酮 | CAS号325775-44-8 1-B°C-3-氨甲基氮杂环丁烷 | CAS号45347-82-8 3-氮杂环丁醇 | CAS号960401-34-7 3-(2-甲氧基-4-硝基苯氧... | CAS号889952-83-4 3-(羧基甲氧基)-1-氮杂环... | CAS号76263-21-3 3-[4-(三氟甲基)苯氧基]氮杂环丁烷 | CAS号1291487-32-5 3-叔丁基亚磺酰亚胺基氮杂环丁... | CAS号1029413-51-1 3-(4-氨基-1H-吡唑-1... | CAS号141699-58-3 N-B°C-3-甲基磺酰氧基氮杂环丁烷

3-Acetoxy-Azetidine-1-Carboxylic Acid Tert-Butyl Ester置于potassium Hydroxide体系中,用 水 用作溶剂,化学反应 0.5H,以31.2 Mg的收率获得n-Boc-3-羟基氮杂环丁烷
参考文献:受保护的 3-卤代氮杂环丁烷的改进的克级合成:氮杂环丁烷-3-羧酸的快速多样化合成
标题:受保护的 3-卤代氮杂环丁烷的改进的克级合成:氮杂环丁烷-3-羧酸的快速多样化合成
摘要:氮杂环丁烷是在各种天然产物和药物化合物中发现的越来越重要的杂环.受保护的 3-卤代氮杂环丁烷是药物化学中广泛使用的通用构件,已在 1-氮杂双环 [1.1.0] 丁烷的一锅,克级应变释放反应中从市售原料制备.这些中间体随后用于制备一系列高价值的氮杂环丁烷-3-羧酸衍生物,包括首次报道的 1-(叔丁氧基羰基)-3-((三氟甲基)硫代)氮杂环丁烷-3-羧酸的合成.
Doi:10.24820/ark.5550190.P010.549

专利信息

专利号:US-2014371464-A1
优先权日:2012-02-03
标 题:Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
发明人：BILLEN DENIS; GREENWOOD SEAN DAVID WILLIAM; STUK TIMOTHY LEE
权利人:ZOETIS LLC
摘要:The invention recites a chiral process for the synthesis of isoxazoline azetidine phenyl substituted derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, processes for making, and their use as a parasiticide in an animal. The variables *, R 1a , R 1b , R 1c , R 2 , and R 3 are as described herein

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:US-2009170828-A1
优先权日:2006-06-12
标题:Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
发明人：ISABEL ELISE; OBALLA RENATA; POWELL DAVID; ROBICHAUD JOEL
权利人:ISABEL ELISE; OBALLA RENATA; POWELL DAVID; ROBICHAUD JOEL
摘要:Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)

专利号:US-2011183958-A1
优先权日:2008-10-17
标 题 :Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; TRANMER GEOFFREY K
权利人:MERCK FROSST CANADA LTD
摘要:Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-7582633-B2
优先权日:2007-01-26
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K; LEGER SERGE
权利人:MERCK FROSST CANADA L L C
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.