CAS: 138279-32-0; 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylic Acid

上下游产品

2,2,6-trimethyl-4H-1,3-dioxin-4-one 2,3-dichlorobenzylaldehyde methyl 3-amin°Crotonate

📜2,2,6-三甲基-4H-1,3-二英-4-酮,2,3-二氯苯甲醛,3-氨基巴豆酸甲酯置于3-羟基丙腈,Sodium Hydroxide体系中,用 异丙醇,二氯甲烷 用作溶剂,化学反应 3.0H,反应生成4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸,4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二羧酸 3-甲酯
参考文献: Preparation Of Intermediates For The Synthesis Of Dihydropyridine Calcium Channel Blockers[fr] Préparation D'Intermédiaires Pour La Synthèse D'Antagonistes Des Canaux Calciques à Base De Dihydropyridine
标题: Preparation Of Intermediates For The Synthesis Of Dihydropyridine Calcium Channel Blockers[fr] Préparation D'Intermédiaires Pour La Synthèse D'Antagonistes Des Canaux Calciques à Base De Dihydropyridine
摘要:4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-5-甲氧羰基-3-吡啶羧酸是合成心血管钙通道阻滞剂药物3-丁酰氧甲氧羰基-5-甲氧羰基-4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢吡啶的关键中间体,纯度大于97%,基本上不含相应的二酸,通过选择性沉淀其羧酸盐,通过加入浓缩的碱金属盐溶液而制备.类似的中间体单羧酸在合成其他非对称取代二氢吡啶药物如尼索地平,尼替地平和尼莫地平时也可以类似地制备和纯化.

专利信息

专利号:WO-2011130852-A1
优先权日:2010-04-21
标题:Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers
发明人：SOUZA FABIO; PAN MING
权利人:ALPHORA RES INC; SOUZA FABIO; PAN MING
摘要:4- (2,3- dichlorophenyl) -1,4- dihydro- 2,6- dimethyl- 5- methoxycarbonyl- 3- pyridinecarboxylic acid, a key intermediate in the synthesis of the cardiovascular calcium channel blocker drug 3-butanoyloxymethoxycarbonyl-5- methoxycarbonyl-4- (2,3-dichlorophenyl) -2,6- dimethyl-1,4- dihydropyridine, of purity greater than 97% and essentially free of the corresponding diacid, is prepared by a process involving selective precipitation of its carboxylate via addition of concentrated solutions of alkali metal salts. Similar intermediate mono-carboxylic acids useful in the synthesis of other unsymmetrically substituted dihydropyrine drugs such as nisoldipine, nitrendipine and nimodipine can be similarly prepared and purified.

专利号:CA-2701272-A1
优先权日:2010-04-21
标 题 :Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers