CAS: 118864-75-8; (S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline

相似化合物

180272-45-1 22990-19-8 118864-75-8

上下游产品

(1S,1'R)-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (S)-(-)-benzyl 1-phenyl-1,2-dihydroisoquinoline-2-carboxylate (S)-(-)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (1S,5R)-5,8,8-trimethyl-1-[(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ylcarbonyl]-3-oxabicyclo[3.2.1]°Ctan-2-one methylene-2,2-dimethyl-1,3-dioxane-4,6-dione5-2-(1-phenyl)tetrahydroisoquinolylmethylene-2,2-dimethyl-1,3-dioxane-4,6-dione (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline (1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]°Ct-3-yl ester solifenacin

2-(2-溴乙基)苯甲醛置于盐酸,Sodium Hydride,Copper(II) Sulfate体系中,用 四氢呋喃,1,4-二氧六环,甲醇,乙醚,二氯甲烷,甲苯,Mineral Oil 用作溶剂,化学反应 24.0H,反应生成(S)-1-苯基-1,2,3,4-四氢异喹啉
参考文献:Stereoselective Total Syntheses Of Solifenacin And N-Acetyl-1-(4-Chlorophenyl)-6,7-Dimethoxytetrahydroisoquinoline
标题:Stereoselective Total Syntheses Of Solifenacin And N-Acetyl-1-(4-Chlorophenyl)-6,7-Dimethoxytetrahydroisoquinoline
摘要:A Highly Stereoselective Synthesis Of 1-Aryl-1,2,3,4-Tetrahydroisoquinoline Drugs Such As Solefinacin (Muscarinic Acetylcholine Receptor Antagonist) And N-Acetyl-1-(4-Chlorophenyl)-6,7-Dimethoxytetrahydroisoquinoline (Ampa Receptor Antagonist) Has Been Accomplished Using (R)-Tert-Butanesulfinamide As A Chiral Source. Chiral Tetrahydroisoquinolines Have Been Prepared Through The Aryl Grignard Addition To Chiral N-Sulfinylimines Followed By Haloamide Cyclization.
Doi:10.1055/s-0034-1378515

专利信息

专利号:US-7741489-B2
优先权日:2007-03-30
标题:Process for the synthesis of solifenacin
发明人：PUIG SERRANO JORDI; CAMPS PELAYO
权利人:MEDICHEM SA
摘要:The present invention provides an improved synthetic strategy for the preparation of solifenacin and pharmaceutically acceptable salts thereof.

专利号:US-2011077405-A1
优先权日:2008-05-23
标题:Process for preparation of enantiomerically pure (s)-1-phenyi-1,2,3,4- tetrahydroisoquinoline
发明人：ZEGROCKA-STENDEL OLIWIA; ZAGRODZKA JOANNA; LASZCZ MARTA
权利人:ZEGROCKA-STENDEL OLIWIA; ZAGRODZKA JOANNA; LASZCZ MARTA
摘要:Process for preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline wherein 1-phenyl-1,2,3,4-tetrahydroisoquinoline is reacted with D-(−)-tartaric acid in a solvent system comprising of methanol and water, preferably at 3.3:1 to 1:1 volume ratio, the crystallization mixture is left for crystallization and (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline is released from obtained crystalline diastereoisomeric salt according to standard procedures. (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the intermediate in enantiomeric synthesis of solifenacin.

专利号:US-2009326230-A1
优先权日:2006-07-19
标题 :Process for preparing solifenacin and its salts
发明人：MATHAD VIJAYAVITTHAL THIPPANNACHAR; LILAKAR JAYDEEPKUMAR DAHYABHAI; GILLA GOVERDHAN; KIKKURU SRIRAMIREDDY; CHINTA RAVEENDRA REDDY; DUDIPALA SWAROOPA
权利人:REDDYS LAB LTD DR; REDDYS LAB INC DR
摘要:The present invention relates to solifenacin in solid form and a process for its preparation and to a process for the preparation of (1S)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline, a key intermediate in the synthesis of solifenacin and its salts.

专利号:US-2010029944-A1
优先权日:2006-11-22
标题:Process for the Synthesis of Solifenacin
发明人：PUIG JORDI; SANCHEZ LAURA; MASLLORENS ESTER; AUGER IGNASI; BOSCH JORDI
权利人:CORPORACION MEDICHEM S L
摘要:This invention provides improved methods for making solifenacin and pharmaceutically acceptable salts thereof. The instant methods are unexpectedly advantageous in their simplicity and efficiency.

专利号:WO-2008120080-A2
优先权日:2007-03-30
标 题:An improved process for the synthesis of solifenacin

专利号:CN-107540606-A
优先权日:2016-06-29
标题 :A kind of method of bidirectional enantioselective synthesis of chiral tetrahydroisoquinoline catalyzed by iridium