CAS: 117704-25-3; Doramectin

相似化合物

51596-11-3 123997-26-2 51596-10-2

专利信息

专利号:WO-2017084064-A1
优先权日:2015-11-19
标题 :Use of electronic olfactory device in on-line detection of cyclohexanecarboxylic acid concentration during dolomycin fermentation
发明人：LING QINGYUN; LI LIN; ZHANG YIWEN
权利人:JIANGSU WEI LING BIOCHEMICAL TECH CO LTD
摘要:Provided is a use of an electronic olfactory device in on-line detection of a cyclohexanecarboxylic acid concentration during dolomycin fermentation. An optimization method for supplementing a precursor during the dolomycin fermentation is determined. Namely, the cyclohexanecarboxylic acid in the fermentation broth is maintained at the optimum concentration by means of on-line detection and feedback of the supplementary addition amount of the precursor substance of cyclohexanecarboxylic acid using the electronic olfactory device, not only satisfying the amount of the precursor required for the bacterial synthesis of doramectin, but also not adversely affecting the metabolic activity of the bacteria. This method makes up for the shortcomings where sampling during the process to perform liquid chromatography or gas chromatography is time-consuming and where it is difficult to achieve on-line detection and timely control.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:US-2023257411-A1
优先权日:2021-11-11
标 题:Synthesis method for selamectin
发明人：CHEN RENER; ZHONG XIUWEN; HUANG YOUCHUN; ZHANG LEI; CHEN WENTENG; YU YONGPING
权利人:ZHEJIANG RONGYAO BIOTECH CO LTD; UNIV ZHEJIANG
摘要:A synthesis method for selamectin was developed, where doramectin is oxidized by manganese dioxide, oximated and de-sugared in one-step by an aqueous solution of hydroxylamine hydrochloride, and then selectively reduced in the presence of Wilkinson's catalyst and hydrogen to obtain selamectin. Doramectin is oxidized to a carbonyl group firstly, so that the generation of impurities during the subsequent reaction is reduced; t-butyl alcohol with a larger steric hindrance is used as a solvent, so that transesterification impurities are avoided; the hydrogenation is implemented in the final step, and the crude product is recrystallized before the hydrogenation reaction, so that the cost is greatly reduced. The method of the present application with an overall yield of 57%. The purity of product was 97.11%. All impurities meet the requirements of Pharmacopoeia. The present application is a simpler, more economical and more efficient synthesis method, and is suitable for industrial production.

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人：FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

专利号:US-10053483-B2
优先权日:2012-04-03
标 题 :Synthesis process of antiparasitic drug selamectin
发明人：YIN MINGXING; WU JIANCHAO; CHAI JIAN
权利人:ZHEJIANG HISUN PHARM CO LTD
摘要:Provided in the present invention are novel key intermediates of selamectin and the preparation method thereof. Also provided is a new synthesis process, using doramectin as a starting material, and obtaining selamectin via hydrogenation, oxidation, oximation and desugaring. The new process of the present invention has few steps, and is simple to operate, high in yield, low in cost and causes little pollution, and is more suitable for large scale industrial production.