CAS: 90035-34-0; 4'-Trifluoromethyl-Biphenyl-4-Carbaldehyde

该化合物是一种有机化合物,其特征是其双苯结构,由两枚苯环组成,由一个单一的联结连接;三氟甲基组(CF3)在一个苯环的副位置上的存在对其化学特性有重大影响,加强其亲脂性并可能改变其反应性; 甲醛功能组(CHO)在其他苯环的副位置上,有助于其再活动,使其成为有机合成中的有用中间体; 这种复合体在表面上一般没有色色,面部为黄色,可能表现出一种独特的气味; 它在有机溶剂(如二氯甲烷和乙醇)中溶解,但水中的溶性有限; 由于氟原子的存在,它可能表现出独特的电子特性,从而引起对材料科学和药用化学的兴趣; 在处理这种化合物时,应当采取安全防范措施,因为如果吸入或浸泡,可能会对健康造成危害.

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物理性质

MSDS等安全信息

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上下游产品

4-Iodobenzotrifluoride 4-formylphenylboronic acid, 4-bromo-benzaldehyde p-trifluoromethylphenyl bromide (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol (R,S)-2-cyclohexyl-1-(4'-trifluoromethyl-biphenyl-4-yl)-ethanol N,N-diethyl-N'-(4'-trifluoromethylbiphenyl-4-ylmethyl)ethane-1,2-diamine 6)-β-D-galactopyranosidep-methoxyphenyl (3,5,9-trideoxy-9-(4'-trifluoromethyl-4-biphenyl)methylamino-5-glycolamido-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2-6)-β-D-galactopyranoside

合成工艺路线路线简述

  • 128796-39-4 + 1122-91-4 = 90035-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Dimethylformamide,Water; 0.5 - 1 H,130 °C
    标题:Vp1 Crystal Structure-Guided Exploration And Optimization Of 4,5-Dimethoxybenzene-Based Inhibitors Of Rhinovirus 14 Infection
    作者:Da Costa,Laurene; Roche,Manon; Scheers,Els; Coluccia,Antonio; Neyts,Johan; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2016 卷标:115 页码:453-462]

    128796-39-4 + 1122-91-4 = 90035-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: 2213470-68-7 Solvents: Dimethylformamide; 5 H,120 °C
    标题:One-Pot Tandem Photoredox And Cross-Coupling Catalysis With A Single Palladium Carbodicarbene Complex
    作者:Hsu,Yu-Cheng; Wang,Vincent C.-C.; Au-Yeung,Ka-Chun; Tsai,Chung-Yu; Chang,Chun-Chi; Et Al
    参考文献:Angewandte Chemie 日期:2018 卷标:57(17) 页码:4622-4626]

    128796-39-4 + 1122-91-4 = 90035-34-0
    反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Catalysts: Palladium,18-Crown-6 Solvents: Methanol,Water; 3 H,45 °C
    标题:18-Crown-6 Promoting Pd/c-Catalyzed Cross-Coupling Reaction Of Aryl Bromides And Arylboronic Acids In Aqueous Media
    作者:Chu,Wenyi; Li,Xinmin; Hou,Yanjun; Wang,Hua; Li,Hongyu; Et Al
    参考文献:Applied Organometallic Chemistry 日期:2012 卷标:26(9) 页码:478-482]

    128796-39-4 + 1122-91-4 = 90035-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrabutylammonium Bromide,Palladium Diacetate Solvents: 1,4-Dioxane,Water; 3 H,Rt -> 70 °C
    标题:Regioselectivity Of Thiouracil Alkylation: Application To Optimization Of Darapladib Synthesis
    作者:Guibbal,Florian; Benard,Sebastien; Patche,Jessica; Meneyrol,Vincent; Couprie,Joel; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2018 卷标:28(4) 页码:787-792]

    128796-39-4 + 15164-44-0 = 90035-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium Diacetate,Poly[oxy[(Chloromethyl)-1,2-Ethanediyl]] (Reaction Products With Methylimidazole And Bis(Trifluoromethylsulfonyl)Imide Ion-Exchanged) Solvents: Water; 1 H,60 °C
    标题:From A Single Helix To A Helical Porous Metalloenzyme Catalyst Based On Temperature Sensitive Polyionic Liquids
    作者:Li,Xinjuan; Zhou,Zhangquan; Dong,Jiaxin; Sun,Yanping; Ma,Guanglei; Et Al
    参考文献:Polymer Chemistry 日期:2022 卷标:13(33) 页码:4789-4797]

    1122-91-4 + 1130440-65-1 = 90035-34-0
    反应条件:1.1 Catalysts: Dichlorobis(Tricyclohexylphosphine)Nickel Solvents: Benzene; 1 H,25 °C
    标题:Nickel-Catalyzed Cross-Coupling Of Organogold Reagents
    作者:Hirner,Joshua J.; Blum,Suzanne A.
    参考文献:Organometallics 日期:2011 卷标:30(6) 页码:1299-1302]

    128796-39-4 + 1122-91-4 = 90035-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium Diacetate Solvents: Ethanol,Water; 1 - 10 Min,17 Bar,100 °C
    标题:Microwave-Assisted Synthesis And Evaluation Of Acylhydrazones As Potential Inhibitors Of Bovine Glutathione Peroxidase
    作者:Wilde,Felix; Lemmerhirt,Heidi; Emmrich,Thomas; Bednarski,Patrick J.; Link,Andreas
    参考文献:Molecular Diversity 日期:2014 卷标:18(2) 页码:307-322]

    128796-39-4 + 104-88-1 = 90035-34-0
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: 2460801-03-8 Solvents: Water; 2 H,30 °C
    标题:(N-Heterocyclic Carbene) Ion-Pair Palladium Complexes: Suzuki-Miyaura Cross-Coupling Studies In Neat Water Under Mild Conditions
    作者:Chen,Ming-Tsz; Lin,Yu-Hsuan; Jian,Kun-Han
    参考文献:Applied Organometallic Chemistry 日期:2020 卷标:34(12)]

    128796-39-4 + 1122-91-4 = 90035-34-0
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Stereoisomer Of Bis[2-[[bis(1-Methylethyl)Phosphino-Kp]Oxy][1,1′-Biphenyl]-3-Yl-... (Mixed Crystal With Trans Isomer),Stereoisomer Of Bis[2-[[bis(1-Methylethyl)Phosphino-Kp]Oxy][1,1′-Biphenyl]-3-Yl-... (Mixed Crystal With Cis Isomer) Solvents: Water; 30 Min,Ph 11,Rt1.2 6 H,30 °C
    标题:An Efficient Protocol For The Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling
    作者:Marziale,Alexander N.; Jantke,Dominik; Faul,Stefan H.; Reiner,Thomas; Herdtweck,Eberhardt; Et Al
    参考文献:Green Chemistry 日期:2011 卷标:13(1) 页码:169-177
📜4-(Formyl)-4'-(Difluoromethyl)Biphenyl置于18-冠醚-6,(+/-)-(1S,2S)-[1,2-Cyclohexanediamino-N,N'-Bis(3,5-Di-T-Butylsalicylidene)]Manganese (Iii) Chloride,Silver Trifluoromethanesulfonate,Cesium Fluoride,亚碘酰苯体系中,用 乙腈 作为反应溶剂,化学反应 0.5H,反应生成 4'-(三氟甲基)联苯-4-甲醛
参考文献:Mn-Salen催化的苄基ch活化,用于合成含芳基[18F] Cf3的pet探针
标题:Mn-Salen催化的苄基ch活化,用于合成含芳基[18F] Cf3的pet探针
摘要:描述了使用[18 F]氟化物开发未活化的ch键的mn-Salen催化的氧化苄基氟化反应,用于安装含[18 F] Chrf,[18 F] Cr 2 F和[18 F] Cf 3的基团.
DOI:10.1039/c4Cc05762G

海关参考信息

专利信息


专利号:US-7781470-B2
优先权日:1999-09-13
标题:Aminodicarboxylic acid derivatives having pharmaceutical properties
发明人：ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.

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摘要:Celik, I.; Hummel, S.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2019) 1, 48.
摘要:Patil, N. T.; Tathe, A. G.; Bhoyare, V. W., Science of Synthesis, (2019) , 143.
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