CAS: 841-77-0; 1-Benzhydrylpiperazine

该化合物是属于管状子衍生物类别的化学化合物;其特点是一个管子环,其特点是由六人组成的饱和异环化合物,含有两个氮原子,代之以一个苯并氢化合物组;该结构有助于其独特的药理特性;该结构经常因其潜在的...

英文名称1-Benzhydrylpiperazine
中文名称二苯甲基哌嗪
IUPAC名称1-benzhydrylpiperazine
其它别名Benzhydrylpiperazine
CAS编号841-77-0
MFCD编号:MFCD00038379
EINECS号:212-667-7
FDA UNII编号:NU6V5ZHD9P
分子式:C17H20N2
分子量:252.35
产品CID: 1830164
产品分类医药中间体 → 哌嗪类化合物

相似结构搜索
产品信息参考;
InChIKey: NWVNXDKZIQLBNM-UHFFFAOYSA-N
InChI=1S/C17H20N2/c1-3-7-15(8-4-1)17(16-9-5-2-6-10-16)19-13-11-18-12-14-19/h1-10,17-18H,11-14H2…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数3.0

MSDS等安全信息

GHS象形图
GHS符号GHS08 & GHS06 & GHS05 & GHS09;
注释: Health hazard & Skull and crossbones & Corrosion & Environment
危险类别急性毒性类别4(经口)
生殖毒性类别2
急性毒性类别3(经口)
特定目标器官毒性-单次接触类别1
特定目标器官毒性-重复接触类别1
严重眼损伤类别1
皮肤致敏类别1A
水生慢性毒性类别2
皮肤腐蚀/刺激类别2
严重眼刺激类别2
皮肤致敏类别1
急性毒性类别4(吸入)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Danger(危险)
危险描述H302 |吞咽有害.
H361 |怀疑对生育能力或胎儿造成损害.
H301 |吞咽会中毒.
H370 |损害器官.
H372 |长期或反复接触损害器官.
H318 |造成严重眼损伤.
H317 |可能引起皮肤过敏反应.
H411 |对水生生物有毒并具有长期持续影响.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H335 |可能引起呼吸道刺激.
防范说明P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn,Xi
安全声明22-24/25
危险类别码22
WGK Germany3

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

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102552-76-1 = 841-77-0
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol
标题:Synthesis Of Heterocyclic Nitrogen Derivatives
作者:Wacht,Elisabeth
参考文献:1993]

102552-76-1 = 841-77-0
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol
标题:Tricyclic Analogs Of The Antiallergic Agent Oxatomide: 1-[3-[4-(10,11-Dihydro-5H-Dibenzo[a,D]Cyclohepten-5-Yl)-1-Piperazinyl]Propyl]-1,3-Dihydro-2H-Benzimidazol-2-One And The Related 6,11-Dihydrodibenzo[b,E]Thiepin,4,9-Dihydrothieno[2,3-C]-2-Benzothiepin,And 10,11-Dihydrodibenzo[b,F]Thiepin Derivatives
作者:Jilek,Jiri; Holubek,Jiri; Svatek,Emil; Metys,Jan; Frycova,Hana; Et Al
参考文献:Collection Of Czechoslovak Chemical Communications 日期:1988 卷标:53(4) 页码:870-83]

142-64-3 + 90-99-3 = 841-77-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; Overnight,Reflux
标题:Selective Naked-Eye Detection Of Hg2+ Through An Efficient Turn-On Photoinduced Electron Transfer Fluorescent Probe And Its Real Applications
作者:Srivastava,Priyanka; Razi,Syed S.; Ali,Rashid; Gupta,Ramesh C.; Yadav,Suresh S.; Et Al
参考文献:Analytical Chemistry (Washington 日期:2014 卷标:86(17) 页码:8693-8699]

142-64-3 + 90-99-3 = 841-77-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran; Overnight,Reflux
标题:A Simple Blue Fluorescent Probe To Detect Hg2+ In Semiaqueous Environment By Intramolecular Charge Transfer Mechanism
作者:Srivastava,Priyanka; Ali,Rashid; Razi,Syed S.; Shahid,Mohammad; Patnaik,Satyakam; Et Al
参考文献:Tetrahedron Letters 日期:2013 卷标:54(28) 页码:3688-3693]

91-01-0 = 841-77-0
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; Rt; 4.5 H,Rt1.2 Solvents: Acetonitrile; 16 H,70 °C
标题:Repurposing The Antihistamine Terfenadine For Antimicrobial Activity Against Staphylococcus Aureus
作者:Perlmutter,Jessamyn I.; Forbes,Lauren T.; Krysan,Damian J.; Ebsworth-Mojica,Katherine; Colquhoun,Jennifer M.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2014 卷标:57(20) 页码:8540-8562]

90-99-3 = 841-77-0
反应条件:1.1 Solvents: Tetrahydrofuran; 45 Min,250 Psi,150 °C
标题:Continuous-Flow Multistep Synthesis Of Cinnarizine,Cyclizine,And A Buclizine Derivative From Bulk Alcohols
作者:Borukhova,Svetlana; Noel,Timothy; Hessel,Volker
参考文献:Chemsuschem 日期:2016 卷标:9(1) 页码:67-74]

90-99-3 = 841-77-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Cyclohexane; Rt; 16 H,Reflux
标题:Palladium-Catalyzed Selective Oxidative Amination Of Olefins With Lewis Basic Amines
作者:Jin,Yangbin; Jing,Yaru; Li,Chunsheng; Li,Meng; Wu,Wanqing; Et Al
参考文献:Nature Chemistry 日期:2022 卷标:14(10) 页码:1118-1125]

90-99-3 = 841-77-0
反应条件:1.1 Solvents: Toluene; 45 - 60 Min,60 - 70 °C; 8 - 10 H,90 - 100 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
标题:Stereoselective Synthesis Of (Z)-1-Benzhydryl-4-Cinnamylpiperazines Via The Wittig Reaction
作者:Shivprakash,S.; Reddy,G. Chandrasekara
参考文献:Synthetic Communications 日期:2014 卷标:44(5) 页码:600-609]

90-99-3 = 841-77-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; 15 Min,Rt1.2 Rt; 8 H,80 °C
标题:Regioselective Synthesis,Antibacterial,Molecular Docking And Fingerprint Applications Of 1-Benzhydrylpiperazine Derivatized 1,4-Disubstituted 1,2,3-Triazoles
作者:Govindaiah,Shivaraja; Sreenivasa,Swamy; Ramakrishna,Ramesha Andagar; Rao,Tadimety Madhu Chakrapani; Nagabhushana,Hanumanthappa
参考文献:Chemistryselect 日期:2018 卷标:3(28) 页码:8111-8117]

90-99-3 = 841-77-0
反应条件:1.1 Reagents: Potassium Carbonate,Potassium Iodide Catalysts: Benzyltriethylammonium Bromide Solvents: Tetrahydrofuran; 8 H,80 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
标题:A Novel Synthetic Approach To Diarylmethylpiperazine Drugs
作者:Yu,Tian; Dong,Hongbo; Shi,Zheng; Cheng,Lijia; Guo,Xiaoheng; Et Al
参考文献:Letters In Organic Chemistry 日期:2018 卷标:15(6) 页码:485-490]

90-99-3 = 841-77-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 10 Min,Rt1.2 Solvents: Dimethylformamide; Rt; 10 H,80 °C
标题:Synthesis And Pharmacological Evaluation Of 1-Benzhydryl Piperazine Derivatives
作者:Thakran,Atul Kumar; Gupta,Sushil; Kumari,Shilpa; Mourya,Abhay Kumar; Alok,Shashi
参考文献:International Journal Of Pharmaceutical Sciences And Research 日期:2012 卷标:3(1) 页码:213-217]

90-99-3 = 841-77-0 [标题:Reaction Conditions
标题:Preparation Of 1-Benzhydrylpiperazine
参考文献:German Democratic Republic]

90-99-3 = 841-77-0
反应条件:1.1 Rt; 12 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 10,Rt
标题:Synthesis And Anti-Convulsant Activity Of Novel Benzhydryl Piperazine Derivatives
作者:Singh,Kuldeep; Shakya,Ashok K.; Alok,Shashi; Naik,Rajashri R.; Kumar,Arun
参考文献:International Journal Of Pharmaceutical Sciences And Research 日期:2022 卷标:13(4) 页码:1777-1784

4-(二苯基甲基)-1-哌嗪羧酸乙酯置于sodium Hydroxide体系中,用乙醇作为反应溶剂,化学反应生成二苯甲基哌嗪
参考文献:Amphoteric Drugs. I. Synthesis And Antiallergic Activity Of (4-(Diphenylmethoxy)Piperidino)-,(4-(Diphenylmethyl)Piperazinyl)-And (4-(Diphenylmethylene)Piperidino)Alkanoic Acid Derivatives.
标题:Amphoteric Drugs. I. Synthesis And Antiallergic Activity Of (4-(Diphenylmethoxy)Piperidino)-,(4-(Diphenylmethyl)Piperazinyl)-And (4-(Diphenylmethylene)Piperidino)Alkanoic Acid Derivatives.
摘要:描述了一种将经典抗组胺药物转化为具有强效的非镇静抗过敏剂的简单方法,该方法在大鼠模型中进行了测试.合成并检查了多种[4-(二苯基甲氧基)哌啶](a系列),[4-(二苯基甲基)哌嗪](b系列)和[4-(二苯基亚甲基)哌啶]酸衍生物(c系列)的抗过敏活性及对中枢神经系统(cns)的影响,与相应的n-甲基衍生物(1A-C)进行了比较.n-烷基羧酸(5A-C)对化合物48/80诱导的大鼠致死作用显示出比相应的n-甲基衍生物(1A-C)更强的抑制效果.特别是a系列中的n-烷基羧酸(5A)表现出大约100倍于1A的更强抑制效果,并且在所有系列中,对于延长戊巴比妥诱导的麻醉睡眠时间的效果最差.通过对a系列进行化学修饰发现,在(二苯基甲氧基)哌啶体系中,在一个苯环的对位引入甲基可以有效降低cns副作用,而不减少抗过敏活性.(+)-3-[4-[(4-甲基苯基)苯基甲氧基]哌啶]丙酸((+)-5L),是5L的光学活性异构体,在48小时同源被动皮肤过敏反应(pca)测试中展现出比酮替芬和特非那定更强的抗过敏效果(ed50 = 0.17 Mg/kg,口服),而且在30 Mg/kg的口服剂量下没有表现出延长戊巴比妥诱导的麻醉睡眠时间等cns副作用.因此,化合物(+)-5L被证明是一个有前景的非镇静抗过敏剂候选药物.
DOI:10.1248/cpb.42.2276

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2902300000-甲苯
2921211000-乙二胺
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专利信息

专利号:WO-2025136243-A1
优先权日:2023-12-20
标题:Mechanochemical synthesis of histamine h1-receptor antagonists
发明人：AYDONAT SIMAY; OZEL MERTCAN; YIGITBASI JOANNA MARIANNA; BAYTEKIN BILGE; COLACINO EVELINA
权利人:IHSAN DOGRAMACI BILKENT UNIV; CENTRE NAT RECH SCIENT
摘要:The present invention relates to mechanochemical synthesis of histamine antagonists which are benzhydryl ethers and unsymmetrically disubstitutes piperazines and salts thereof. Said antihistamine active pharmaceutical ingredients can be diphenhydramine hydrochloride, cyclizine hydrochloride and diphenylpyraline hydrochloride. These antihistamines are used in the treatment of allergies, hives, hay fever (allergic rhinitis), conjunctivitis, reactions to insect bites and sings, nausea, motion sickness, insomnia.

专利号:US-2005019747-A1
优先权日:2002-08-07
标题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.

专利号:CA-2539670-A1
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:US-5215987-A
优先权日:1990-04-23
标题:Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
发明人：HAJOS ZOLTAN G; KANOJIA RAMESH M; PRESS JEFFREY B
权利人:ORTHO PHARMA CORP
摘要:Substituted benzhydryl 2-hydroxypropyl piperazine derivatives and methods of synthesis of the derivatives are described. The substituted benzhydryl 2-hydroxypropyl piperazine derivatives are useful as cardiotonic agents.

专利号:WO-2005028619-A2
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:US-8916705-B2
优先权日:2011-10-14
标题:Procaspase-activating compounds and compositions
发明人：HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

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常州市力仁医药科技有限公司

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企业联系电话：0519-85859058,13915836899👤
地址:江苏省常州市天宁区东仓桥弄1号

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合成参考文献

摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 386.
参考文献:10.1007/bf01273360
摘要:Gasior M, Kamiński R, Brudniak T, Kleinrok Z, Czuczwar SJ. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J Neural Transm (Vienna). 1996;103(7):819–31. doi: 10.1007/bf01273360.

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CAS: 841-77-0; 1-Benzhydrylpiperazine

该化合物是属于管状子衍生物类别的化学化合物;其特点是一个管子环,其特点是由六人组成的饱和异环化合物,含有两个氮原子,代之以一个苯并氢化合物组;该结构有助于其独特的药理特性;该结构经常因其潜在的...

物理性质

MSDS等安全信息

欧盟法规

上下游产品

合成工艺路线路线简述

海关参考信息

专利信息

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