CAS: 82857-40-7; N-Methyl-3-Phenyl-3-(O-Tolyloxy)Propan-1-Amine Hydrochloride

专利信息

专利号:US-7507861-B2
优先权日:2004-06-28
标题:Process for the preparation of atomoxetine hydrochloride
发明人：CASTELLI EUGENIO; LO MONACO GIUSEPPE; MANTOVANI SILVIA; DAVERIO PAOLA; RIVA PAOLO; VAILATI ALESSANDRA; BIANCHI STEFANO
权利人:TEVA PHARM FINE CHEMICALS SRL
摘要:The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water.

专利号:US-7439399-B2
优先权日:2004-06-28
标题:Processes for the preparation of atomoxetine hydrochloride
发明人：ARONHIME JUDITH; BIANCHI STEFANO; CASTELLI EUGENIO; DAVERIO PAOLA; MANTOVANI SILVIA; KOVACSNE-MEZEI ADRIENNE
权利人:TEVA PHARM FINE CHEMICALS SRL
摘要:The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.

专利号:EP-1673335-A2
优先权日:2004-06-28
标 题 :Process for the preparation of atomoxetine hydrochloride
发明人：CASTELLI EUGENIO; LO MONACO GIUSEPPE; MANTOVANI SILVIA; DAVERIO PAOLA; RIVA PAOLA; BIANCHI STEFANO
权利人:TEVA PHARM FINE CHEMICALS SRL
摘要:The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC1 by adding HCl to a mixture of (R)-(-)-tomoxetine (S)-(+)­mandelate with an organic solvent, with or without a base and water.

专利号:US-5510516-A
优先权日:1990-07-06
标 题 :Process for selective epoxidation of unsaturated (meth)acrylates, new functional (meth)acrylates obtained and their application to the synthesis of new polymers
发明人：CAUBERE PAUL; FORT YVES; ORTAR AGNES
权利人:ATOCHEM
摘要:An unsaturated (meth) acrylic compound of formula: (I) (X=O, S, NH, NR3 (R3=C1-12-alkyl) or O-(CH2)n (where n=1-16 approximately); R2=C2-20 straight-chain or branched alkyl, monocyclic or polycyclic cycloalkyl or heterocycloalkyl, or alkylaryl hydrocarbon chain, comprising an olefinic double bond in the chain, or at the end of the chain in the case of alkyl or alkylaryl, or an exocyclic or endocyclic olefinic double bond in the case of monocyclic or polycyclic cycloalkyl or heterocycloalkyl; and R1=H or C1-5-alkyl), is reacted at 10 DEG -60 DEG C. with at least one oxidising compound (hydrogen peroxide) in the presence of at least one catalyst (alkali metal molybdates and tungstates) and in the presence of at least one phase transfer agent and when R2=polycyclic cycloalkyl or hetercycloalkyl, an organic peracid or hydrogen peroxide in the presence of at least one heteropolyacid. To open the epoxide function, the epoxide obtained is reacted with a compound chosen from strong inorganic acids, boron trifluoride etherate complexes, acid salts in the presence of the corresponding acid, halides of trialkylsilanes or trialkoxysilanes, and ketones in the presence of cationic resins.

专利号:US-2008004470-A1
优先权日:2004-09-27
标 题:Synthesis of Atomoxetine Hydrochloride
发明人：MATHAD VIJAYAVITTHAL T; GHANTA MAHESH R; GOVINDAN SHANMUGAM; MACHARLA PRABHAKAR; NALIVELA VENU
权利人:MATHAD VIJAYAVITTHAL T; GHANTA MAHESH R; GOVINDAN SHANMUGAM; MACHARLA PRABHAKAR; NALIVELA VENU
摘要:(±)-Atomoxetine oxalate having crystalline Form II and a solid (±)-atomoxetine free base are useful in preparing atomoxetine hydrochloride.

专利号:WO-2008062473-A1
优先权日:2006-10-31
标 题 :Process for preparing atomoxetine hydrochloride
发明人：PATEL VIPUL KANTIBHAI; KUMAR RAJIV; DHAR DWIVEDI SHRIPRAKASH
权利人:CADILA HEALTHCARE LTD; PATEL VIPUL KANTIBHAI; KUMAR RAJIV; DHAR DWIVEDI SHRIPRAKASH
摘要:The present invention relates to the process for preparing Atomoxetine hydrochloride which is a selective norepinephrine reuptake inhibitor. Atomoxetine HCl is chemically known as (-)-iV-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride and represented by formula (I). More particularly, the invention relates to crystalline form of N-methyl-3-phenyl-3-(o- tolyloxy) propylamine oxalate (here in after referred as '(±) Atomoxetine Oxalate'), which is an useful intermediate for the synthesis of Atomoxetine hydrochloride.