CAS: 74472-45-0; 2,3,3',4',5',6-Hexachlorobiphenyl

该化合物是疏水性,低挥发性,高热稳定性,使其耐受环境降解.由于其化学稳定性,它可能存在于生态系统和食物链的生物积累中,使人们对其毒性和对人类和野生物的潜在健康影响产生担忧.六氯联苯已知具有内分泌干扰特性,并且与包括癌症和生殖问题在内的各种有害健康后果有关.结果是,多氯联苯的生产和使用,包括2,3,3',3',4',5',6-六氯联苯的生产和使用,在许多国家基本上受到禁止或限制.

英文名称2,3,3',4',5',6-Hexachlorobiphenyl
中文名称2,3,3,4,5,6-六氯联苯
IUPAC名称1,2,3-trichloro-5-(2,3,6-trichlorophenyl)benzene
其它别名2,3,3',4',5',6-Hexachlorobiphenyl
CAS编号74472-45-0
MFCD编号:MFCD00792642
FDA UNII编号:6NP0VW2MQN
分子式:C12H4Cl6分子量:360.88
产品CID: 1734788
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: HAZQOLYHFUUJJN-UHFFFAOYSA-N
1S/C12H4Cl6/c13-6-1-2-7(14)12(18)10(6)5-3-8(15)11(17)9(16)4-5/h1-4H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,2,3-trichloro-5-iodobenzene 1,2,4-trichloro-3-iodobenzene 2,3,6-trichloroanisole 1,2,3-trichlorobenzene

合成工艺路线路线简述

📜2,3,6-Trichloroaniline,三氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,3,3,4,5,6-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4