CAS: 594-20-7; 2,2-Dichloropropane

该化合物是一种有机化合物,被归类为氯化碳氢化合物;其特点是三碳丙烷脊柱,配有与第二碳相连的两个氯原子,导致C3H6Cl2分子分子分子式的C3H6Cl2;这种无色液体的味道甜,相对而言不单极,在有机溶剂中溶解,但在水中却较少,其沸点高于非氯化的对口,因为氯原子的存在增加了分子重量和中间分子力量. 2,2-二氯丙烷主要用作各种化学品合成的中间体和工业应用中的溶剂.必须谨慎地处理这一化合物,因为吸入或摄入这种化合物可能有害,而且因其在环境中持续存在的可能性而可能造成环境风险.适当的安全措施,包括使用个人防护设备,在与该物质合作时至关重要.

结构式图片

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ECHA物质ECHA物质C&L通报REACH预注册

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CAS号67-64-1 丙酮 | CAS号127-06-0 丙酮肟 | CAS号557-98-2 2-氯丙烯 | CAS号74-99-7 丙炔 | CAS号75-29-6 2-氯丙烷 | CAS号13283-01-7 六氯化钨 | CAS号74-98-6 丙烷 | CAS号7782-50-5 氯气 | CAS号7647-01-0 盐酸 | CAS号7705-08-0 三氯化铁 | CAS号557-98-2 2-氯丙烯 | CAS号463-49-0 丙二烯 | CAS号594-85-4 2,3-dichloro-2,... | CAS号563-79-1 2,3-二甲基-2-丁烯 | CAS号75-29-6 2-氯丙烷 | CAS号7647-01-0 盐酸 | CAS号562-49-2 3,3-二甲基戊烷 | CAS号2310-98-7 2-氯-2-溴丙烷 | CAS号98-82-8 异丙基苯 | CAS号74-99-7 丙炔

合成工艺路线路线简述

    📜丙烷 反应生成 2,2-二氯丙烷
    参考文献:Hass Et Al.,Industrial And Engineering Chemistry,1936,Vol. 28,P. 1179
    标题:Hass Et Al.,Industrial And Engineering Chemistry,1936,Vol. 28,P. 1179

    海关参考信息

    专利信息


    专利号:US-4111933-A
    优先权日:1976-04-30
    标题:Protection of functional groups during reaction and their subsequent restoration
    发明人:ECKERT HEINER; UGI IVAR; KABBE HANS-JOACHIM
    权利人:BAYER AG
    摘要:In the process for preparing an organic compound of the formula n n A' -- X n n in which n X is an amino group, a hydroxyl group or a carboxyl group, and n A' is the remainder of the molecule, from an organic compound of the formula n n A -- X n n in which n A is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formula n n A -- Z -- COOR n n in which n Z is --NH--, --O-- or a direct C--C bond, and n R is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CHâ•?CH-- group or an arylene group, n R 1 to R 4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, or n R 1 + r 2 and R 3 + R 4 each independently completes a 5- or 6-membered carbocyclic ring, or n R 1 and R 3 conjointly with the grouping --C--Y--C-- forms a carbocyclic ring with 5 or 6 carbon atoms, and Hal is halogen, n Thereby to protect X, then converting A -- Z -- COOR into a compound of the formula n n A' -- Z -- COOR n n and then treating the compound A' -- Z -- COOR to restore the group X, the improvement which comprises effecting the treatment of the compound A' -- Z -- COOR with an alkali metal compound of a complex of monovalent cobalt. The process is applicable particularly to aminocarboxylic acids including intermediates from various stages of the synthesis of penicillins and cephalosporis.

    专利号:US-5780579-A
    优先权日:1993-08-10
    标题:Method for the preparation of polyamino acids
    发明人:SOULA GERARD; GROSSELIN JEAN-MICHEL; JORDA RAFAEEL; CASTAN CATHERINE
    权利人:FLAMEL TECH SA
    摘要:PCT No. PCT/FR94/00992 Sec. 371 Date Mar. 28, 1996 Sec. 102(e) Date Mar. 28, 1996 PCT Filed Aug. 9, 1994 PCT Pub. No. WO95/04772 PCT Pub. Date Feb. 16, 1995The present invention relates to a method for the preparation of polyamino acids, with controlled molecular weights, by polymerization of N-carboxyanhydrides (NCAs) of at least one amino acid, using at least one initiator of the strong base type and in liquid medium, characterized in that it consists in including, in the liquid reaction medium, given amounts of water and/or of alcohol. Application: synthesis of polyamino acids with mechanical and rheological characteristics adapted to applications as biomaterials.

    专利号:US-4859799-A
    优先权日:1985-09-09
    标 题 :Process for the production of aldehyde or ketone compounds and aldehydes and ketones obtained by means of this process
    发明人:CAMPESTRINI SANDRO; DI FURIA FULVIO; MODENA GIORGIO; PASQUATO LUCIA
    权利人:INTEROX SA
    摘要:Process for the production of aldehydes or ketones by oxidative cleavage of olefinic double bonds by means of a coordination complex of a ligand and a peroxo derivative of a metal of group 6b. n Aldehydes and ketones obtained by said process are used among others as intermediates in the synthesis of organic products.

    专利号:US-7468452-B1
    优先权日:2007-12-12
    标题 :Process for one-pot synthesis of 1,1-diphenyl-1-(3-substituted-cyclopentadienyl)-1-(2,7-di-t-butyl-fluoren-9-yl)methane type ligands
    发明人:MARTIN JOEL L; MASINO ALBERT P; YANG QING
    权利人:CHEVRON PHILLIPS CHEMICAL CO
    摘要:The present invention is directed to a method of making a ligand which can be used to form an ansa-metallocene. Further, the present invention is directed to a method of making the ansa-metallocene. In both methods the process steps employed to form the ligand are conducted in the presence of tetrahydrofuran, a substituted tetrahydrofuran, tetrahydropyran, a substituted tetrahydropyran or ethylene glycol dimethyl ether.

    专利号:US-9556208-B2
    优先权日:2012-10-12
    标题 :Hydrosilylation synthesis of haloalkylorganosilanes using peroxide promoters
    发明人:LEWIS KENRICK MARTIN; RATHORE JITENDRA SINGH; TROTTO ANDREA; D'AGOSTINO GIUSEPPE
    权利人:MOMENTIVE PERFORMANCE MAT INC
    摘要:This invention is directed to a process for producing a haloorganoalkoxysilane product comprising reacting an olefinic halide, an alkoxysilane, a catalytically effective amount of ruthenium-containing catalyst; and a reaction-promoting effective amount of a peroxy compound, optionally in the presence of an electron-deficient aromatic compound.

    专利号:WO-2023151188-A1
    优先权日:2022-02-08
    标题 :Green synthesis method of antiviral drug intermediate
    发明人:XIA BIN; WANG JIAMING; ZHANG XIANSHU; CAI LINGLI; WANG ZIKUN; CAO MING; YANG SHAOBO; GAO QIANG; ZHENG BAOFU
    权利人:SHANGHAI HAOYUAN CHEMEXPRESS CO LTD
    摘要:The present application provides a green synthesis method of an antiviral drug intermediate. The method comprises: in the presence of a catalyst, adding zinc powder into a compound as represented by a formula II and performing a cyclization reaction with dihaloalkane to generate a compound as represented by a formula I, zinc halide being not required to be added to the cyclization reaction, wherein R1 is selected from H or an amino-protecting group, and R2 is selected from substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C6-C14 aryl or substituted or unsubstituted C7-C14 aralkyl; R3 and R4 are each independently selected from hydrogen, substituted or unsubstituted C1-C10 alkyl, and R3 and R4 can be connected to form a fatty ring containing 3-10 carbon atoms. The synthesis method is short in steps, dangerous and expensive materials are not used, a reaction conversion rate is high, reaction time is short, and operation is easy and convenient. Production costs and post-treatment costs are reduced, and a cost advantage is obvious. The method can be widely used for preparing antiviral drugs of nirmatrelvir, boceprevir or narlaprevir, and has good market prospects.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis Knowledge Updates, (2011) 3, 13.
    摘要:Inoue, S.; Driess, M., Science of Synthesis Knowledge Updates, (2012) 4, 234.
    参考文献:10.1107/s1600536810043692
    摘要:Peulecke N, Peitz S, Müller BH, Spannenberg A, Rosenthal U. [2,2-Bis(diphenylphosphanyl)propane-κ2P,P′]tetracarbonylchromium(0) dichloromethane monosolvate. Acta Crystallogr E Struct Rep Online. 2010 Oct 31;66(11):m1495. doi: 10.1107/s1600536810043692.
    参考文献:10.1124/dmd.32.1.123
    摘要:Tornero-Velez R, Ross MK, Granville C, Laskey J, Jones JP, DeMarini DM, Evans MV. Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane. Drug Metab Dispos. 2004 Jan;32(1):123–31. doi: 10.1124/dmd.32.1.123.
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