专利号:US-6448412-B1 优先权日:1995-07-31 标题:Methods for the preparation and characterization of multi-substituted fullerenes 发明人:MURPHY RANDALL B; WILSON STEPHEN R; LU QUING 权利人:SPHERE BIOSYSTEMS INC 摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.
专利号:US-10723766-B2 优先权日:2015-11-27 标题 :Derivatives of gamma-amanitin 发明人:WERNER-SIMON SUSANNE; LUTZ CHRISTIAN; MüLLER CHRISTOPH; SIMON WERNER 权利人:HEIDELBERG PHARMA RES GMBH 摘要:The invention relates to γ-amaninamide (1; x=0, 1 or 2), γ-amaninamidic acid (2; x=0, 1 or 2), and γ-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of γ-amanitin (4), and methods and novel building blocks for the synthesis thereof.
专利号:US-8273403-B2 优先权日:2002-05-10 标题 :Generation of surface coating diversity 发明人:BARDEN MICHAEL C; KAMBOURIS PETER A 权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD 摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.
专利号:WO-9636631-A1 优先权日:1995-05-19 标题:Multiply-substituted fullerenes and methods for their preparation and characterization 发明人:MURPHY RANDALL B; WILSON STEPHEN R; LU QUING 权利人:SPHERE BIOSYSTEMS INC 摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.
专利号:CN-108727269-A 优先权日:2018-07-13 标题 :A kind of preparation method of N(Ï„)-methyl-L-histidine derivative and its application in the synthesis of anserine
专利号:CN-112218876-B 优先权日:2018-04-10 标题 :Synthesis of end-capped lixisenatide
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