CAS: 5662-95-3; 8-Oxaspiro[4.5]Decane-7,9-Dione

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CAS号16713-66-9 1,1-环戊烷二乙酸 | CAS号861342-71-4 [1-(carbamoyl-c... | CAS号861616-96-8 cyclopentyliden... | CAS号21098-05-5 8-(2-氯-乙基)-8-氮杂... | CAS号36505-84-7 丁螺环酮 | CAS号25032-23-9 8-(prop-2-ynyl)... | CAS号1075-89-4 3,3-四亚甲基戊二酰亚胺 | CAS号118856-18-1 8-((3-(4-(1,2-b... | CAS号64744-43-0 8-hydroxy-8-aza...

📜7,9-二氧代-8-氮杂螺[4.5]癸烷-6,10-二甲腈置于氯化亚砜,硫酸,乙酸酐体系中,化学反应 3.0H,反应生成 3,3-四亚甲基戊二酸酐
参考文献:Antiproliferative And Antibacterial Activity Of Some Glutarimide Derivatives
标题:Antiproliferative And Antibacterial Activity Of Some Glutarimide Derivatives
摘要:Antiproliferative And Antibacterial Activities Of Nine Glutarimide Derivatives (1-9) Were Reported. Cytotoxicity Of Compounds Was Tested Toward Three Human Cancer Cell Lines,Hela,K562 And Mda-Mb-453 By Mtt Assay. Compound 7 (2-Benzyl-2-Azaspiro[5.11] Heptadecane-1,3,7-Trione),Containing 12-Membered Ketone Ring,Was Found To Be The Most Potent Toward All Tested Cell Lines (Ic50 = 9-27 Mu M). Preliminary Screening Of Antibacterial Activity By A Disk Diffusion Method Showed That Gram-Positive Bacteria Were More Susceptible To The Tested Compounds Than Gram-Negative Bacteria. Minimum Inhibitory Concentration (Mic) Determined By A Broth Microdilution Method Confirmed That Compounds 1,2,4,6-8 And 9 Inhibited The Growth Of All Tested Gram-Positive And Some Of The Gram-Negative Bacteria. The Best Antibacterial Potential Was Achieved With Compound 9 (Ethyl 4-(1-Benzyl-2,6-Dioxopiperidin-3-yl) Butanoate) Against Bacillus Cereus (Mic 0.625 Mg/ml; 1.97 X 10(-3) Mol/l). Distinction Between More And Less Active/inactive Compounds Was Assessed From The Pharmacophoric Patterns Obtained By Molecular Interaction Fields.
DOI:10.3109/14756366.2015.1070844

专利信息

专利号:US-6872856-B2
优先权日:2000-06-28
标 题 :Cyclic ketones, their preparation and their use in the synthesis of amino acids
发明人：BLAKEMORE DAVID CLIVE; BRYANS JUSTIN STEPHEN
权利人:WARNER LAMBERT CO
摘要:A method is provided for making an enantiomerically pure compound of the formula: in which R and R′ represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g. in the case of the acetoxy compound, a trans 3,4-disubstituted addition product of formula III or IV; The acetyl group is eliminated from the addition product to give an (R)- or (S)-4-alkyl or 4-alkenyl cyclopent-2-en-1-one the compound of formula is then to be hydrogenated to give a cyclopentanone of formula (I) or conjugate addition of a second organometallic nucleophile that provides a group R′ as defined above to the compound of the above formula may be carried out to give a trans 3,4-disubstituted addition product of formula (II). One of the above compounds may be converted e.g. via an intermediate (XV)-(XVIII) (in which the substituents R and R′ and the wedges have the meanings indicated above) to a gabapentin analogue of one of the formulae shown below: in which the substituents R and R′ and the wedges also have the meanings indicated above.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-2003187296-A1
优先权日:2000-06-28
标题 :Cyclic ketones, their preparation and their use in the synthesis of amino acids

专利号:US-2005215816-A1
优先权日:2000-06-28
标 题 :Cyclic ketones, their preparation and their use in the synthesis of amino acids

专利号:US-5719286-A
优先权日:1992-06-16
标 题:Process and intermediates for bis-aza-bicyclic anxiolytic agents
发明人：URBAN FRANK JOHN
权利人:PFIZER
摘要:Optically pure intermediates of formula (1) wherein the substituent B is either cis or trans to the C 9a -C 1 bond and is selected from the group consisting of --CH 2 OH, --CHO, --CH 2 OSO 2 R, --CH 2 CN, --CH(OH)CH 2 NO 2 , --CHâ•?CH--NO 2 , (2) and (3), C is selected from the group consisting of --H, (4), (5), and a nitrogen protecting group which is removable by hydrogenation or acid treatment; and wherein R is (C 1 -C 8 ) alkyl, phenyl or alkyl substituted phenyl; X is N or CH; Y is O or S and Z is H or Cl; for the synthesis of octahydro-1H-pyrido(1,2-a)pyrazinyl ethyl carboxamide anxiolytic agents.

专利号:RU-2090565-C1
优先权日:1991-02-27
标题 :Racemic or optically active perhydro-1h-pyrido-[1,2-a]-pyrazines or their pharmaceutically acceptable salts and method of their synthesis