CAS: 4816-80-2; (S)-2-(4-Methylphenylsulfonamido)Pentanedioic Acid

相似化合物

1155-62-0 121343-82-6 138-15-8

上下游产品

CAS号56-86-0 L-谷氨酸 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号32677-01-3 L-谷氨酸二叔丁酯盐酸盐 | CAS号21957-65-3 L-Proline,1-[(4... | CAS号56-85-9 L-谷氨酰胺 | CAS号70-55-3 对甲苯磺酰胺 | CAS号2650-65-9 H-GLN-GLY-OH | CAS号13716-89-7 (S)-4-氨基-5-((羧甲... | CAS号83870-97-7 4-(methylcarbam... | CAS号83870-98-8 4-(ethylcarbamo... | CAS号83870-99-9 L-Glutamine,N2-... | CAS号5963-60-0 N-苯基-L-谷氨酰胺

L-谷氨酸置于sodium Hydroxide体系中,用 水 作为反应溶剂,以93%的收率获得产物n-对甲苯磺酰-L-谷氨酸
参考文献:Chemoselective Intramolecular Functionalization Of Methyl Groups In Nonconstrained Molecules Promoted By N-Iodosulfonamides
标题:Chemoselective Intramolecular Functionalization Of Methyl Groups In Nonconstrained Molecules Promoted By N-Iodosulfonamides
摘要:Mechanistic Evidence Observed In Hofmann-Loffler-Freytag-Type Reactions Has Been Crucial To Achieve The Chemoselective Functionalization Of Methyl Groups Under Mild Conditions. Radical-Mediated Methyl Iodination And Subsequent Oxidative Deiodination Are The Key Steps In This Functionalization,Where Iodine Chemistry Has A Pivotal Role On The Formation Of The C-N Bond. The Concepts Of Single Hydrogen Atom Transfer (Shat) And Multiple Hydrogen Atom Transfer (Mhat) Are Introduced To Describe The Observed Chemoselectivity.
DOI:10.1021/acs.Orglett.5B00866

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-5322944-A
优先权日:1991-07-01
标 题:Process for the synthesis of enantiomers of 3-aminochroman compounds
发明人：GUILLAUMET GERALD; FUGIER CLAUDE; SOUVIE JEAN-CLAUDE J; ADAM GERARD; RENARD PIERRE; CAIGNARD DANIEL-HENRI
权利人:ADIR
摘要:Process for preparing enantiomers of general formula (I): ##STR1## where Z, R 1 , R 2 , R 3 and n are defined in the description. The compounds obtained according to the invention are useful as medicinal products.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:US-4370500-A
优先权日:1978-11-06
标题:Compound: d-N-(2-amino-2-phenethyl)-2-methoxyethylamine and process for preparing the same by selective crystallization
发明人：KUROSE NANCY S
权利人:AMERICAN CYANAMID CO
摘要:There is provided a new compound: d-N-(2-amino-2-phenethyl-2-methoxyethylamine useful in the direct synthesis of levamisole. The compound is prepared by slurrying the racemic N-(2-amino-2-phenethyl)-2-methoxyethylamine with dibenzoyl-d-tartaric acid as the resolving agent in an aqueous acidic menstruum containing ammonium chloride, heating the resultant mixture, preferably under reflux, cooling and filtering the resultant mixture to recover crystals rich in the desired d-amine compound, hereinabove noted.

专利号:IE-922131-A1
优先权日:1991-07-01
标 题:'New process for the synthesis of enantiomers of 3-aminochroman compounds'

专利号:US-2017057909-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof