专利号:US-4681936-A 优先权日:1985-02-15 标 题:Preparation of sugar ketals 发明人:PFAFF KLAUS-PETER; PAUST JOACHIM; HARTMANN HORST 权利人:BASF AG 摘要:Sugar ketals are prepared by reacting a sugar with a ketone in the presence of an acid catalyst by a process in which n A. a molecular boron trifluoride compound or trifluoromethanesulfonic acid is used in an amount of only from 0.01 to 10% by weight, based on the sugar used, n B. up to a 30-fold molar excess of the ketone is used and n C. the water formed during the reaction is removed continuously from the reaction mixture. n In a particularly advantageous embodiment of the process, the boron trifluoride is used in the form of boron trifluoride etherate and, when the reaction is complete, this compound or the trifluoromethanesulfonic acid is rendered ineffective under non-aqueous conditions, after which the ketone is evaporated off and the reaction mixture is then subjected to fractional distillation. The process is particularly important for the reaction of L-sorbose with acetone to obtain 2,3:4,6-di-O-isopropylidene-L-sorbofuranose, which is required for the synthesis of ascorbic acid.
专利号:US-2023279170-A1 优先权日:2022-03-02 标 题:Chiral-substituted poly-n-vinylpyrrolidinones and complexes with bimetallic nanoclusters and uses thereof 发明人:HUA DUY H 权利人:UNIV KANSAS STATE 摘要:Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.
专利号:US-2004181078-A1 优先权日:1997-10-10 标 题 :Tetraphosphonate bicyclic trisanhydrides 发明人:PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A 权利人:PHARMASSET LTD 摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
专利号:EP-3908587-B1 优先权日:2019-01-09 标题 :Method for synthesis of diazabicyclo[6.2.0]decane related compounds
专利号:US-2022112207-A1 优先权日:2019-01-09 标 题:Method for synthesis of diazabicyclo[6.2.0]decane related compounds
专利号:US-6713623-B2 优先权日:1996-10-09 标 题:Tetraphosphonate bicyclic trisanhydrides 发明人:PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A 权利人:PHARMASSET LTD 摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.