CAS: 4099-88-1; (3Ar,6R,6Ar)-6-(Hydroxymethyl)-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Ol

该化合物是一种D-ribofuransose受保护的衍生物,在2,3个位置上有一个异丙基环十二酸组,这加强了合成应用的稳定性和选择性.该化合物在碳水化合物化学和核核循环合成中特别有用,作为制造复杂分子的关键中间体. 异丙基环十二酯保护防止2,3-羟基组出现意外的副作用,同时允许其他位置进一步功能化. 高纯度和定义明确的立体化学使其成为制药,抗病毒剂和其他生物活性化合物的可靠建筑块. 该化合物与一系列反应条件的兼容性进一步凸显了其在有机合成中的实用性.

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4099-85-8 217309-46-1 4137-56-8

上下游产品

CAS号554-62-1 糖脂 | CAS号24259-59-4 L-核糖 | CAS号115509-13-2 (3aR,6aR)-2,2-二... | CAS号1949-78-6 L-谷胺酸酯

合成工艺路线路线简述

    📜卡培他滨杂质25置于硫酸,水,Palladium Dichloride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 2,3-异亚丙氧基-D-呋喃核糖苷
    参考文献:乙烯基醚和乙烯基核苷在紫外线引发的自由基与受体单体的共聚反应中的反应性
    标题:乙烯基醚和乙烯基核苷在紫外线引发的自由基与受体单体的共聚反应中的反应性
    摘要:研究了富马酸二乙酯或马来酸二乙酯存在下核糖的各种乙烯基醚和乙烯基氧基衍生物的反应性,以评估施用于可再生原料的不饱和单体的供体-受体型共聚反应的潜力.通过红外光谱监测本体状态的模型单体共混物的光化学诱导的聚合.该方法使我们能够检查单体对结构对动力学曲线的影响.观测到两种单体的同时消耗,支持交替的共聚机理.与富马酸酯相比,证实了含有马来酸酯的共混物的反应性较低.所获得的动力学数据揭示了初始聚合速率和汉森参数δh之间的一般相关性 与供体单体的h键结合能力有关.
    DOI:10.1021/bm1005883

    海关参考信息

    专利信息


    专利号:US-4681936-A
    优先权日:1985-02-15
    标 题:Preparation of sugar ketals
    发明人:PFAFF KLAUS-PETER; PAUST JOACHIM; HARTMANN HORST
    权利人:BASF AG
    摘要:Sugar ketals are prepared by reacting a sugar with a ketone in the presence of an acid catalyst by a process in which n A. a molecular boron trifluoride compound or trifluoromethanesulfonic acid is used in an amount of only from 0.01 to 10% by weight, based on the sugar used, n B. up to a 30-fold molar excess of the ketone is used and n C. the water formed during the reaction is removed continuously from the reaction mixture. n In a particularly advantageous embodiment of the process, the boron trifluoride is used in the form of boron trifluoride etherate and, when the reaction is complete, this compound or the trifluoromethanesulfonic acid is rendered ineffective under non-aqueous conditions, after which the ketone is evaporated off and the reaction mixture is then subjected to fractional distillation. The process is particularly important for the reaction of L-sorbose with acetone to obtain 2,3:4,6-di-O-isopropylidene-L-sorbofuranose, which is required for the synthesis of ascorbic acid.

    专利号:US-2023279170-A1
    优先权日:2022-03-02
    标 题:Chiral-substituted poly-n-vinylpyrrolidinones and complexes with bimetallic nanoclusters and uses thereof
    发明人:HUA DUY H
    权利人:UNIV KANSAS STATE
    摘要:Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.

    专利号:US-2004181078-A1
    优先权日:1997-10-10
    标 题 :Tetraphosphonate bicyclic trisanhydrides
    发明人:PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A
    权利人:PHARMASSET LTD
    摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.

    专利号:EP-3908587-B1
    优先权日:2019-01-09
    标题 :Method for synthesis of diazabicyclo[6.2.0]decane related compounds

    专利号:US-2022112207-A1
    优先权日:2019-01-09
    标 题:Method for synthesis of diazabicyclo[6.2.0]decane related compounds

    专利号:US-6713623-B2
    优先权日:1996-10-09
    标 题:Tetraphosphonate bicyclic trisanhydrides
    发明人:PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A
    权利人:PHARMASSET LTD
    摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2022)
    摘要:Robina, I.; Vogel, P., Science of Synthesis, (2008) 37, 720.
    摘要:Robina, I.; Vogel, P., Science of Synthesis, (2008) 37, 712.
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