CAS: 397843-58-2; (3-(Morpholinomethyl)Phenyl)Boronic Acid

上下游产品

CAS号110-91-8 吗啉 | CAS号51323-43-4 3-(溴甲基)苯硼酸 | CAS号1025113-70-5 potassium 3-(mo...

📜Potassium 3-(Morpholinomethyl)-Phenyltrifluoroborate置于水,Silica Gel体系中,用 乙酸乙酯 用作溶剂,化学反应 3.0H,以64%的收率获得3-吗啉甲基苯硼酸
参考文献:通过硅胶和水有效水解有机三氟硼酸盐
标题:通过硅胶和水有效水解有机三氟硼酸盐
摘要:开发了一种使用硅胶和 H 2 O水解有机三氟硼酸盐以揭示硼酸的通用,温和且有效的方法.事实证明,该方法可以耐受各种芳基-,杂芳基-,烯基-和烷基三氟硼酸盐以及结构多样的氨甲基化有机三氟硼酸盐.正如预期的那样,由于共振稳定的二氟硼烷中间体,富电子底物比缺电子底物更容易提供相应的硼酸.开发的方法进一步扩展用于将有机三氟硼酸盐转化为相应的硼酸酯.
Doi:10.1021/jo901441U

专利信息

专利号:US-6919382-B2
优先权日:2000-08-31
标 题 :Preparation and uses of conjugated solid supports for boronic acids
发明人：HALL DENNIS G
权利人:UNIV ALBERTA
摘要:The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.