CAS: 39684-28-1; O-(Tert-Butyl)Hydroxylamine Hydrochloride

相似化合物

4490-81-7 6084-58-8 3332-29-4

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CAS号51951-30-5 N-(tert-butoxy)... | CAS号326801-14-3 Methyl 2-fluoro... | CAS号455-68-5 3-氟苯甲酸甲酯 | CAS号292618-32-7 ST1481 | CAS号608520-17-8 ethyl 3-[(2-met...

Ethyl O-Tert-Butylacetohydroxamate置于盐酸体系中,用 水 作为反应溶剂,化学反应 2.5H,以88.5%的收率获得产物o-叔丁基羟胺盐酸盐
参考文献:O-取代羟胺盐酸盐及其制备方法
标题:O-取代羟胺盐酸盐及其制备方法
摘要:本发明提供一种o‑取代羟胺盐酸盐及其制备方法,其中,制备方法包括如下步骤:步骤s1,向乙酰羟肟酸乙酯的乙醇溶液中加氢氧化钠,此外同时滴加卤代烃,磺酰氯或酰氯以发生取代反应,此后加到水中以析出o‑取代乙酰羟肟酸乙酯;步骤s2,将所述o‑取代乙酰羟肟酸乙酯加入盐酸溶液中回流反应以反应生成o‑取代羟胺盐酸盐.根据本发明实施例的o‑取代羟胺盐酸盐的制备方法,能够得到纯度高的产品,且该方法安全,易处理,工艺简单,适合工业化生产.

专利信息

专利号:WO-2023225524-A1
优先权日:2022-05-17
标题:Preparation of highly concentrated mrna
发明人：GENG MARK; SINOIMERI JAMES
权利人:MODERNATX INC
摘要:Provided herein are compositions of highly concentrated mRNA and related methods for preparation and use of the compositions as mRNA process intermediates in the synthesis of therapeutic and prophylactic mRNA formulations.

专利号:WO-2013010573-A1
优先权日:2011-07-18
标 题:Compounds with matrix-metalloproteinase inhibitory activity
发明人：HAUFE GUENTER; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; HERMANN SVEN; SCHAEFERS MICHAEL; KOLB HARTMUTH
权利人:UNIV MUENSTER; SIEMENS MEDICAL SOLUTIONS; HAUFE GUENTER; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; HERMANN SVEN; SCHAEFERS MICHAEL; KOLB HARTMUTH
摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention.

专利号:US-6512143-B1
优先权日:1998-07-10
标 题:Salts of N-tert-butylhydroxylamine
发明人：BLIXT JOERGEN
权利人:ASTRAZENECA AB
摘要:Novel salts of N-tert-butylhydroxylamine with lower carboxylic acids are disclosed, together with processes for their preparation. The salts possess advantageous properties that render them useful in synthesis.

专利号:US-5510511-A
优先权日:1992-01-14
标 题 :Process for preparing N,O-dialkylhydroxylamine, its salts or intermediates in their synthesis
发明人：INOKI SATOSHI; TAKESUE MITSUYUKI; HASHIMOTO ISAO; KIHARA NORIAKI; SUGI KIYOAKI
权利人:MITSUI PETROCHEMICAL IND
摘要:A process for preparing N,O-dialkylhydroxycarbamic acid ester which comprises reacting hydroxylamine or its salt with dihydrocarbyl carbonate in the presence of a basic compound to prepare hydroxycarbamic acid ester and subsequently alkylating this compound with an alkylating agent; a process for recovering N,O-dialkylhydroxycarbamic acid ester which comprises azeotropically distilling the ester with water from a solution containing the ester; a process for preparing N,O-dialkylhydroxylamine which comprises hydrolyzing N,O-dialkylhydroxycarbamic acid ester in an aqueous solution or a hydrous solvent in the presence of an alkali; a process for purifying N,O-dialkylhydroxylamine hydrochloride which comprises adding aldehyde or ketone to a solution of N,O-dialkylhydroxylamine hydrochloride containing O-alkylhydroxylamine hydrochloride as impurities to convert the O-alkylhydroxylamine hydrochloride into O-alkyl aldoxime or O-alkyl ketoxime and subsequently separating the N,O-dialkylhydroxylamine hydrochloride from the reaction system; and a process for separating N,O-dialkylhydroxylamine hydrochloride which comprises (i) adding benzene or alkylated benzene to an aqueous solution containing N,O-dialkylhydroxylamine hydrochloride, azeotropically removing water or a hydrochloride solution, and, subsequently (ii)adding alcohol thereto to obtain N,O-dialkylhydroxylamine hydrochloride in the form of crystal.

专利号:MX-PA04003330-A
优先权日:2001-10-09
标题 :4- (2-FUROIL) NOVEDOUS AMINOPIPERIDINS, INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF THE SAME, PROCESS FOR PRODUCERS AND THEIR MEDICINAL USE.

专利号:RU-2172316-C2
优先权日:1994-12-07
标题 :Rapamycin 42-oximes and hydroxylamines, method of synthesis, intermediate compounds, pharmaceutical composition and method of treatment of patient