CAS: 36896-17-0; Acetimidamide (Acetate)

该化合物是乙酰胺化学上稳定的衍生物,其特点是增加了一个乙酰胺组.这种改变提高了其在水溶性和极有机溶剂中的溶性,使之适合各种合成和生化应用.复合物表现出高度纯度和持续的再活动性,这有利于用于核生殖反应和作为制药合成的中间体.其定义明确的分子结构确保了复杂反应路径的可预见行为.伊森米达米德单子乙酸酯在研究环境中因其在受控制条件下产生高当量,可复制的结果的可靠性而特别受到重视.建议适当的处理和储存以保持其稳定性.

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124-42-5 1040352-82-6 1452099-14-7

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上下游产品

CAS号52386-40-0 3-甲基-1,2,4-噁二唑-... | CAS号64-19-7 冰醋酸 | CAS号124-42-5 乙脒盐酸盐 | CAS号127-09-3 乙酸钠 | CAS号53135-24-3 2-甲基-4-羟基嘧啶-5-羧酸乙酯 | CAS号779326-74-8 4,5-二氢-4-氧代-3H-... | CAS号61457-13-4 5-methyl-2H-thi... | CAS号55933-85-2 5-乙酰基-2,4-二甲基嘧啶

合成工艺路线路线简述

    📜盐酸乙脒,Sodium Acetate 以 正丁醇 作为反应溶剂,化学反应 0.5H,反应生成 乙酸乙脒
    参考文献:Wo2007/18941
    标题:Wo2007/18941

    海关参考信息

    专利信息


    专利号:US-8198443-B2
    优先权日:2007-01-19
    标题 :Synthesis of 4-amino-pyrimidines scaffolds
    发明人：BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA
    权利人:BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA; DSM IP ASSETS BV
    摘要:Process for the manufacture of a compound of the structure (I) with R1=hydrogen, alkyl (C1-C10, linear, cyclic or branched, aliphatic or aromatic), NR′R″ (wherein R′ and R″ are independently selected from H, alkyl [C1-C10, linear, cyclic or branched, aliphatic or aromatic] and R2=CH2R3 wherein R3 is selected from NHR1′″ (with R′″=C(O)H, C(O)CH3, C(O)alkyl, CH2C6H2(OMe)3 or other saponifiable residues), alkyl (C1-C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e.g. 3,4,5-trimethoxy-phenyl) wherein 1 equivalent of an α-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid.

    专利号:US-4886910-A
    优先权日:1987-02-17
    标题 :Cyanoguanidine derivative and process for preparation thereof
    发明人：TAN HIROAKI; KATO KOJI; IMUTA JUNICHI; KIHARA NORIAKI
    权利人:MITSUI PETROCHEMICAL IND
    摘要:The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N'-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-guanidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H 2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.

    专利号:EP-2102172-B1
    优先权日:2007-01-19
    标 题:Synthesis of 4-amino-pyrimidines

    专利号:EP-1972620-A1
    优先权日:2007-01-19
    标题:Synthesis of 4-amino-pyrimidines

    专利号:TW-201943719-A
    优先权日:2018-04-10
    标 题:Synthesis of boron complex with oxygen-containing polydentate ligand

    专利号:EP-2102172-A1
    优先权日:2007-01-19
    标题:Synthesis of 4-amino-pyrimidines

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    合成参考文献


    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 205.
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