CAS: 3177-24-0; 2,4-Dichloropyrimidine-5-Carbonitrile

相似化合物

871254-61-4 1240390-28-6 3029-64-9

专利信息

专利号:EP-1248788-B1
优先权日:1999-12-29
标 题 :Synthesis of isosorbide mononitrate
发明人：MARSTON RICHARD WALDRON; QUIGLEY PAUL FINBAR; BROWN CHRISTOPHER MARTIN; ROBERTS STANLEY MICHAEL; CROSS SIMON JOHN
权利人:CLARIANT LSM ITALIA SPA
摘要:A method of synthesising a compound of formula (1), in which each of R<1> and R<2> is independently selected from H or optionally substituted straight or branched chain C1-C30 alkyl, C1-C30 carboxyalkyl, C1-C30 sulphoxyalkyl, C1-C30 alkoxy, C3-C30 cycloalkyl, C3-C30 carboxycycloalkyl, C3-C30 sulphoxycycloalkyl, C3-C30 cycloalkoxy, heterocyclic, carboxyheterocyclic, sulphoxyheterocyclic, oxyheterocylic, C3-C30 cycloalkenyl, carboxycycloalkenyl, sulphoxycycloalkenyl or cycloalkenoxy, C8-C30 cycloalkynyl, carboxycycloalkynyl, sulphoxycycloalkynyl or cycloalkynoxy, C2-C30 alkynyl, carboxyalkynyl, sulphoxyalkynyl or alkynoxy group, C4-C30 aromatic, carboxyaromatic, sulphoxyaromatic or aryloxy, C4-C30 heteroaromatic, carboxyheteroaromatic, sulphoxyheteroaromatic or heteroaryloxy group, wherein in any of the hereto atom-containing groups the hetero atom is selected from O, S, and N; comprises treating a compound of formula (2) with a reducing system effective to reduce preferentially the compound of formula (2) at the 2-position to produce the compound of formula (1), wherein the reducing system comprises (i) hydrogen in the presence of a platinum-containing catalyst, or (ii) a hybride source in the presence of a transition metal phthalocyanine or polyphthalocyanine in which the transition metal is iron and/or cobalt.

专利号:US-3655665-A
优先权日:1965-04-08
标 题 :Process for the production of 5-cyano-uracils
发明人：MEINDL HUBERT; ACKERMANN HANS; KAENEL FRED VON
权利人:CIBA GEIGY AG
摘要:A PROCESS FOR THE PRODUCTION OF 5-CYANO-URACILS IS DESCRIBED COMPRISING (A) RING CLOSING A COMPOUND OF THE FORMULA R1-N(-R2)-C(-R3)=C(-CN)-CO-NH-CO-NH2 IN THE PRESENCE OF AN ALKALINE CONDENSING AGENT AT A TEMPERATURE OF FROM ABOUT 30 TO 150*C., OR (B) REACTING A COMPLEX OF THE FORMULA R3-C(+)(-X)-N(-R1)-R2 Y(-) WITH CYANACETYL UREA, THEREBY OBTAINING THE COMPOUND OF HE ABOVE FORMULA B AND RING CLOSING SAID COMPOUND WITH AN ALKALINE CONDENSING AGENT. THE 5-CYANO-URACILS OBTAINED ARE VALUABLE INTERMEDIATES IN THE SYNTHESIS OF DYESTUFFS.

专利号:US-10326145-B2
优先权日:2012-04-11
标题 :Synthesis of electrocatalysts using metal-organic framework materials
发明人：LIU DI-JIA; ZHAO DAN
权利人:LIU DI JIA; ZHAO DAN; UCHICAGO ARGONNE LLC
摘要:Methods and compositions for use in the preparation of MOF-based non-PGM electrocatalysts including combining transition metal compounds with organic ligands and secondary building units to create a solid mixture, heating the solid mixture to form a MOF through a solid-state reaction, optionally heating the MOF to convert it to an electrocatalyst via pyrolysis, and optionally post-treating. The electrode catalysts may be used in various electrochemical systems, including a proton exchange membrane fuel cell.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CA-2857947-A1
优先权日:2011-03-15
标题 :Facile synthesis of graphene, graphene derivatives and abrasive nanoparticles and their various uses, including as tribologically-beneficial lubricant additives

专利号:BR-112013023547-A2
优先权日:2011-03-15
标题 :easy synthesis of graphene, graphene derivatives and abrasive nanoparticles and their various uses, including as tribologically beneficial lubricant additives