CAS: 29070-92-6; Pachymic Acid

📜Pachymic Acid Phthalimidomethyl Ester置于sodium Hydroxide体系中,用 乙醇,氯仿 用作溶剂,以20 Mg的收率获得茯苓酸
参考文献:从茯苓菌核中分离出具有乙酰氧基的羊毛甾烷型三萜酸
标题:从茯苓菌核中分离出具有乙酰氧基的羊毛甾烷型三萜酸
摘要:摘要 通过邻苯二甲酰亚胺甲酯的制备型高效液相色谱法以及邻苯二甲酰亚胺甲酯基团的选择性水解,有效地从茯苓菌核中分离出带有乙酰氧基的羊毛甾烷型三萜酸.通过这种方法,分离出三种新的三萜酸,以及作为hoelen特征化合物的厚皮酸和脱氢厚皮酸.根据光谱证据,确定了三种新化合物的结构分别为 3-O-乙酰基-16α-羟基脱氢曲美烯酸和 3-表皮氢重甲酸.
Doi:10.1016/0031-9422(95)00182-7

专利信息

专利号:US-9321804-B2
优先权日:2011-03-09
标题 :Synthesis and use of anti-tumor drug LQC-Y
发明人：LEI HAIMIN
权利人:UNIV BEIJING CHINESE MEDICINE; 3D MEDICINES LTD
摘要:Disclosed are the general structural formula of LQC-Y as well as the synthesis and use thereof. Pharmacological experiments demonstrated the marked antitumor effect of such compounds. Single day administration of LQC-Y3 to mice at a maximum dose of 6000 mg/kg showed no toxicity response during the 14-day continuous observation period, indicating the high safety of the compounds, and the compounds can be used to prepare medicaments for preventing and treating carcinomas such as liver cancer, lung cancer. In the general structural formula of LQC-Y, R represents steroid compounds such as cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid and so on; triterpenoid compounds such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides thereof and so on; emodic acid, emodin and other mono-substituted or poly-substituted structures of anthraquinone parent nucleus; baicalein, baicalin and other flavonoid; shikimic acid, mono-substituted shikimic acid or poly-substituted shikimic acid; gardenia acid and other iridoid acid derivatives; paeonol, curcumin and structural derivatives thereof.

专利号:US-2014011786-A1
优先权日:2011-03-09
标题:Synthesis and use of anti-tumor drug lqc-y