CAS: 2901-80-6; 2-Benzamido-3-Methylbutanoic Acid

相似化合物

5699-79-6 42807-41-0 91565-90-1

上下游产品

CAS号98-88-4 苯甲酰氯 | CAS号516-06-3 DL-缬氨酸 | CAS号201230-82-2 carbon monoxide | CAS号709-25-1 N-(2-methylally... | CAS号67-56-1 甲醇 | CAS号28897-81-6 2-phenyl-4-iso-... | CAS号72-18-4 l-缬氨酸 | CAS号2901-80-6 苯甲酰-DL-缬氨酸 | CAS号583-05-1 1-苯基-1,4-戊二酮 | CAS号1738-54-1 N-(2-methylprop... | CAS号26823-15-4 5-methyl-1-phen... | CAS号4252-31-7 N-Formylbenzamide | CAS号4441-01-4 1,2,4-三苯基-1,4-丁二酮

📜(R)-N-[1-(Furan-2-yl)-2-Methylpropyl]Benzamide置于sodium Periodate,水合三氯化钌体系中,用 四氯化碳,水,乙腈 用作溶剂,以96%的收率获得d-N-苯甲酰缬氨酸
参考文献:在n-(叔丁烷亚磺酰基)亚胺中添加三有机锌酸酯对α-氨基酸的对映选择性合成
标题:在n-(叔丁烷亚磺酰基)亚胺中添加三有机锌酸酯对α-氨基酸的对映选择性合成
摘要:高度对映体富集的n-保护的α-氨基酸可以很容易地由光学纯的n-(叔丁烷亚磺酰基)亚胺通过以下四个步骤序列制得:非对映选择性地向亚胺中添加三有机锌,亚磺酰基的去除,苯甲酰基的苯甲酰化获得的伯胺的氮原子被碳原子α上的取代基之一氧化成氮.在亚磺酰基手性助剂中使用相同的配置,具有(R)或(s可以通过选择亚胺和有机锌酸盐的适当组合来制备构型.具有高光学纯度的α,α-二取代的α-氨基酯也可以通过将三烷基锌酸酯非对映选择性地加成到α-亚氨基酯中来制备.
Doi:10.1016/j.Tetlet.2009.05.008

专利信息

专利号:US-4808607-A
优先权日:1985-05-22
标题 :Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:US-4755606-A
优先权日:1985-05-22
标 题 :Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:US-4668794-A
优先权日:1985-05-22
标 题 :Intermediate imidazole acrolein analogs
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.