专利号:US-6214875-B1 优先权日:1998-04-14 标题:Anticancer effects of specific branched-chain fatty acids and related production process 发明人:YANG ZHENHUA 摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.
专利号:US-9187524-B2 优先权日:2010-09-15 标题 :Broad spectrum antibiotic arylomycin analogs 发明人:ROMESBERG FLOYD E; SMITH PETER A; ROBERTS TUCKER C 权利人:ROMESBERG FLOYD E; SMITH PETER A; ROBERTS TUCKER C; SCRIPPS RESEARCH INST 摘要:Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.
专利号:MX-2007005591-A 优先权日:2004-11-08 标 题:SYNTHESIS OF CARDIOLIPINE ANALOGS AND USES OF THE SAME.
专利号:CN-1714095-A 优先权日:2002-10-16 标题:Cardiolipin molecules and method of synthesis
专利号:US-7070965-B1 优先权日:1998-04-14 标 题:Small molecule anticancer compounds and related production process 发明人:YANG ZHENHUA 权利人:YANG ZHENHUA 摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.
专利号:CN-1726183-A 优先权日:2002-10-16 标题:Cardiolipin molecules and method of synthesis
参考标题:Convergent Synthesis Of Calcium-Dependent Antibiotic Cda3A And Analogues With Improved Antibacterial Activity Via Late-Stage Serine Ligation 作者:Delin Chen,Kathy Hiu Laam Po,Pilar Blasco,Sheng Chen,Xuechen Li |发布日期:2020.6.19 摘要:A Convergent Synthesis Via The Late-Stage Serine Ligation Of Naturally Occurring Calcium-Dependent Antibiotic Cda3A And Its Analogues Has Been Developed, Which Allowed Us To Readily Synthesize The Analogues With The Variation On The Lipid Tail. Some Analogues Were Found To Show 100-500-Fold Higher Antimicrobial Activity Than The Natural Compound Cda3A Against Drug Resistant Bacteria. This Study Will
合成参考文献
参考文献:10.1007/s11745-015-4077-x 摘要:Santalova EA, Denisenko VA, Dmitrenok PS. Structural Analysis of the Minor Cerebrosides from a Glass Sponge Aulosaccus sp. Lipids. 2015 Dec;50(12):1209–18. doi: 10.1007/s11745-015-4077-x.