CAS: 2724-56-3; 10-Methylundecanoic Acid

该化合物是一种以其独特的分子结构为特征的分支链式脂肪酸,以第10个碳位置上的一个甲基组为特征,这种结构改变增强了其物理化学特性,使其在有机合成,润滑剂配方和表面活性剂生产等专门应用中具有价值.这种分解提高了非极溶剂的溶解性和热稳定性,而箱式酸功能允许进一步衍生.其中间链长和疏水性能特性有助于其创造具有特定性能特征的定制化合物的效用.该化合物通常通过受控有机反应合成,确保研究和工业用途的高度纯度和一致性.

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CAS号106787-53-5 11-methyl-dodec... | CAS号20194-45-0 10-甲基十一烷醇 | CAS号920-39-8 异丙基溴化镁 | CAS号626-88-0 1-溴-4-甲基戊烷 | CAS号50530-06-8 sodium 6-bromoh... | CAS号34386-60-2 2-methyldodec-1... | CAS号111-81-9 10-十一烯酸甲酯 | CAS号503-74-2 异戊酸 | CAS号2104-19-0 壬二酸单甲酯 | CAS号20194-45-0 10-甲基十一烷醇 | CAS号5638-08-4 26-methylheptac... | CAS号6250-72-2 18-甲基十九烷酸

合成工艺路线路线简述

    📜8-溴-1-辛醇置于potassium Permanganate,Sodium Hydroxide体系中,用 四氢呋喃,水,叔丁醇 用作溶剂,化学反应 136.25H,反应生成10-甲基十一烷酸
    参考文献:Stereoselective Synthesis Of Unnatural (2S,3S)-6-Hydroxy-4-Sphingenine-Containing Sphingolipids
    标题:Stereoselective Synthesis Of Unnatural (2S,3S)-6-Hydroxy-4-Sphingenine-Containing Sphingolipids
    摘要:使用水锆化反应和不寻常的三步一锅脱保护序列,简洁地合成含有鞘氨醇脂类的unnatural (2S,3S)-6-羟基-4-鞘氨醇.
    Doi:10.1039/c9Ob00990F

    海关参考信息

    专利信息


    专利号:US-6214875-B1
    优先权日:1998-04-14
    标题:Anticancer effects of specific branched-chain fatty acids and related production process
    发明人:YANG ZHENHUA
    摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

    专利号:US-9187524-B2
    优先权日:2010-09-15
    标题 :Broad spectrum antibiotic arylomycin analogs
    发明人:ROMESBERG FLOYD E; SMITH PETER A; ROBERTS TUCKER C
    权利人:ROMESBERG FLOYD E; SMITH PETER A; ROBERTS TUCKER C; SCRIPPS RESEARCH INST
    摘要:Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.

    专利号:MX-2007005591-A
    优先权日:2004-11-08
    标 题:SYNTHESIS OF CARDIOLIPINE ANALOGS AND USES OF THE SAME.

    专利号:CN-1714095-A
    优先权日:2002-10-16
    标题:Cardiolipin molecules and method of synthesis

    专利号:US-7070965-B1
    优先权日:1998-04-14
    标 题:Small molecule anticancer compounds and related production process
    发明人:YANG ZHENHUA
    权利人:YANG ZHENHUA
    摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

    专利号:CN-1726183-A
    优先权日:2002-10-16
    标题:Cardiolipin molecules and method of synthesis

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    主要参考文献

    参考标题:Convergent Synthesis Of Calcium-Dependent Antibiotic Cda3A And Analogues With Improved Antibacterial Activity Via Late-Stage Serine Ligation
    作者:Delin Chen,Kathy Hiu Laam Po,Pilar Blasco,Sheng Chen,Xuechen Li |发布日期:2020.6.19
    摘要:A Convergent Synthesis Via The Late-Stage Serine Ligation Of Naturally Occurring Calcium-Dependent Antibiotic Cda3A And Its Analogues Has Been Developed, Which Allowed Us To Readily Synthesize The Analogues With The Variation On The Lipid Tail. Some Analogues Were Found To Show 100-500-Fold Higher Antimicrobial Activity Than The Natural Compound Cda3A Against Drug Resistant Bacteria. This Study Will

    合成参考文献


    参考文献:10.1007/s11745-015-4077-x
    摘要:Santalova EA, Denisenko VA, Dmitrenok PS. Structural Analysis of the Minor Cerebrosides from a Glass Sponge Aulosaccus sp. Lipids. 2015 Dec;50(12):1209–18. doi: 10.1007/s11745-015-4077-x.
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