CAS: 26892-90-0; Ethyl 4-Hydroxyquinoline-3-Carboxylate
该化合物是一种多用途的七环化合物,在4级和3级以氢氧基组替代一个基质核心,在4级和6级为1个基质基质组,这种结构具有适合医药中间体,有机合成和协调化学应用的回动性,是合成生物活性分子,包括抗微生物剂和抗脉冲剂的宝贵前体,其酯性功能允许进一步衍生,而氢氧基组则能提高溶性并参与氢联结.乙酰四氧基-3-碳箱状体在标准条件下展示稳定性,便利处理和储存.其平衡的再活动性和结构特征使它成为药用化学和材料科学研究的有用基石.
- 英文名称Ethyl 4-Hydroxyquinoline-3-Carboxylate
- 中文名称3-乙氧羰基-4-喹啉
- IUPAC名称ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
- 其它别名4-羟基喹啉-3-甲酸乙酯; 4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester
- CAS编号26892-90-0
- MFCD编号:MFCD00173406
- EINECS号:803-448-2
- FDA UNII编号:C69YF4B94W
- 分子式:C12H11NO3分子量:217.22
- 产品CID: 1248382
- 产品分类有机原料→分子砌块→芳杂环类化合物→喹啉类化合物
相似化合物
7509-12-8 34785-11-0 63463-15-0物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别严重眼刺激 类别2
皮肤腐蚀/刺激 类别2
特定目标器官毒性 - 单次接触 类别3
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H319 |造成严重眼刺激.
H315 |造成皮肤刺激.
H335 |可能引起呼吸道刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- UN编号NONH for all modes of transport
- 危险品标志Xi
- 安全声明26
- 危险类别码36
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号54535-22-7 2-苯基氨基亚甲基-丙二酸二乙酯 | CAS号87-13-8 乙氧甲叉 | CAS号497-19-8 纯碱 | CAS号34785-11-0 4-羟基喹啉-3-羧酸 | CAS号72368-50-4 ethyl 2-(formyl... | CAS号87-25-2 2-氨基苯甲酸乙酯 | CAS号360795-67-1 ethyl 2-is°Cyan... | CAS号34785-11-0 4-羟基喹啉-3-羧酸 | CAS号13721-01-2 4-氧代-1,4-二氢喹啉-3-羧酸 | CAS号21168-46-7 (4-chloroquinol... | CAS号611-35-8 4-氯喹啉 | CAS号13720-94-0 4-氯喹啉-3-甲基乙酯 | CAS号18471-99-3 1-甲基-4-氧代-1,4-二... | CAS号77779-36-3 2-(4-chlorophen... | CAS号77779-50-1 CGS-9895 | CAS号77779-60-3 2-phenylpyrazol...合成工艺路线路线简述
- 合成目标产物 4-Hydroxyquinoline-3-Carboxylic Acid Ethyl Ester 主要起始原料 Aniline And Diethyl Ethoxymethylenemalonate
- (文献来源)合成步骤主要原料 Aniline 和 Diethyl Ethoxymethylenemalonate
海关参考信息
- 2902200000-苯
2912110000-甲醛
2915110000-甲酸
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.
专利号:US-10336703-B2
优先权日:2015-05-12
标题 :Process for the synthesis of ivacaftor and related compounds
发明人：REDDY DUMBALA SRINIVASA; NATARAJAN VASUDEVAN; JACHAK GORAKHNATH RAJARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.
专利号:US-2018127373-A1
优先权日:2015-05-12
标题:Process for the synthesis of ivacaftor and related compounds
专利号:EP-4043439-B1
优先权日:2016-05-30
标题:An improved process for the synthesis of ivacaftor
专利号:EP-3464243-A2
优先权日:2016-05-30
标 题:An improved process for the synthesis of ivacaftor
专利号:WO-2017208253-A2
优先权日:2016-05-30
标 题:An improved process for the synthesis of ivacaftor
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 317.
摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 359.
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