专利号:US-11485823-B2 优先权日:2017-06-29 标 题:Polymer for delivery of biologically active materials 发明人:YANG YI-YAN; YANG CHUAN; CHENG WEI; LEE ASHLYNN 权利人:AGENCY SCIENCE TECH & RES 摘要:The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.
专利号:US-2014011972-A1 优先权日:2011-02-08 标 题:Carbocatalysts for polymerization 发明人:BIELAWSKI CHRISTOPHER W; DREYER DANIEL R 权利人:BIELAWSKI CHRISTOPHER W; DREYER DANIEL R; GRAPHEA INC 摘要:Provided herein are novel processes for synthesis of polymers and/or polymer composites.
专利号:CN-105152995-B 优先权日:2014-10-09 标 题 :A kind of mercapto compound and method thereof for catalyzing acetyl transfer synthesis of β-ester group
专利号:US-2018161300-A1 优先权日:2015-05-11 标题:Citrin inhibitors for the treatment of cancer 发明人:EREZ AYELET; RABINOVICH SHIRAN; SILBERMAN ALON; AGRON SHANI 权利人:YEDA RES & DEV; YEDA RES & DEV 摘要:Provided are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of an agent which downregulates a mitochondrial aspartate-dependent pyrimidine synthesis, thereby treating the cancer.
专利号:US-10399925-B2 优先权日:2014-05-16 标题:Beta-hydroxylated tertiary diamines, a process for their synthesis and their use for eliminating acid compounds a gaseous effluent 发明人:GRANDJEAN JULIEN; DELFORT BRUNO; LE PENNEC DOMINIQUE; HUARD THIERRY; WENDER AURELIE; NIGON ARMELLE 权利人:IFP ENERGIES NOW 摘要:The invention relates to novel nitrogen compounds belonging to the family of tertiary diamines of general formula (I) below, wherein R is an alkanediyl radical —(CH 2 )n- with n=2, 3, 4, 5 or 6. n nThe compound according to the invention is for example N,N,N′,N′-(tetramethyl)-1,6-diamino-2,5-hexanediol or N,N,N′,N′-(tetramethyl)-1,8-diamino-2,7-octanediol. The invention also relates to the method for preparing them and to their use for removing acid compounds contained in a gaseous effluent.
专利号:FR-3005050-A1 优先权日:2013-04-26 标题:SULFUR POLYOL COMPOUND USEFUL AS MONOMER FOR SYNTHESIS OF POLYURETHANE