CAS: 22115-41-9; 2-Cyanobenzyl Bromide

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CAS号529-19-1 邻甲基苯腈 | CAS号557-21-1 氰化锌 | CAS号3433-80-5 邻溴溴苄 | CAS号100-39-0 溴化苄 | CAS号120578-03-2 3-[(1E)-2-(7-氯-... | CAS号92065-71-9 N,N-dimethyl-3-... | CAS号507-09-5 硫代乙酸 | CAS号612-13-5 邻氰基氯苄 | CAS号7726-95-6 溴素 | CAS号109722-74-9 6,11-dihydroind... | CAS号106020-70-6 2-(甲氧基甲基)苯甲醛 | CAS号344957-25-1 2-氰基苯胺 | CAS号3759-28-2 2-氰基苯乙腈 | CAS号468751-38-4 2-(苯磺酰甲基)苯甲醛 | CAS号195067-13-1 (9ci)-3-氨基-1H-茚... | CAS号18328-00-2 2-(2-cyanoethyl... | CAS号22780-52-5 1H-异吲哚-3-胺 | CAS号87-41-2 苯酞 | CAS号2674-47-7 spiro[4H-is°Chr...

邻甲基苯腈置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳 用作溶剂,化学反应 5.08H,以69%的收率获得2-氰基溴苄
参考文献:取代的5,6,11,12-四氢加氢二苯并[ A,E ]环辛烯:取代的桑德海默-黄迪因斯的合成,性质和dft研究
标题:取代的5,6,11,12-四氢加氢二苯并[ A,E ]环辛烯:取代的桑德海默-黄迪因斯的合成,性质和dft研究
摘要:高应变环乙炔5,6,11,12-四氢二苯并[ A,E在苯环上具有各种取代基的]环辛烯(sondheimer-Wong Diynes)是通过用氯代磷酸二乙酯/六甲基二硅化锂(lihmds)然后二异丙基氨基化锂(lda)一锅法处理相应的甲砜而成功合成的.当将带有不同取代基的两种类型的甲砜混合物进行此操作时,不对称取代的sondheimer-Wong Diynes可以通过逐步分离杂化的乙烯基砜中间体,然后用lda处理来逐步合成.记录了取代的sondheimer-Wong Diynes的uv-Vis吸收光谱和循环伏安图.通过其点击反应以及亲核和亲电加成,研究了取代基对二炔的电子效应.
Doi:10.1021/jo502248P

专利信息

专利号:WO-0027627-A1
优先权日:1998-11-12
标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
发明人：WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.

专利号:WO-2010146391-A1
优先权日:2009-06-15
标题:Regioselective synthesis of letrozole
发明人：GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
权利人:GENERICS UK LTD; MYLAN INDIA PRIVATE LTD; GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
摘要:The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:WO-2015092739-A1
优先权日:2013-12-19
标题:Process for preparation of alogliptin
发明人：VADALI LAKSHMANA RAO; DASARI SRINIVASA RAO; MANUKONDA SESHADRI RAO; PONDURI RAJASEKHAR
权利人:MYLAN LAB LTD
摘要:Processes for the preparation of alogliptin benzoate are disclosed. The present disclosure also provides intermediates useful in the synthesis of alogliptin benzoate.

专利号:US-2014303333-A1
优先权日:2011-10-14
标题:Iron bisphenolate complexes and methods of use and synthesis thereof
发明人：SHAVER MICHAEL P; KOZAK CHRISTOPHER M
权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC
摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

专利号:US-5939392-A
优先权日:1993-06-03
标 题 :Method of thrombin inhibition
发明人：ANTONSSON KARL THOMAS; BYLUND RUTH ELVY; GUSTAFSSON NILS DAVID; NILSSON NILS OLOV INGEMAR
权利人:ASTRA AB
摘要:The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.